Last updated: 11/07/2018 17:33:21
An International, Randomized, Double-Blind Study to Compare the Safety and Efficacy of MALARONE (Atovaquone and Proguanil Hydrochloride) Versus Chloroquine and Proguanil Hydrochloride for Chemoprophylaxis Against Malaria in Non-Immune Travelers
Clinicaltrials.gov ID
Not applicable
EudraCT ID
Not applicable
EU CT Number
Not applicable
Trial status
Study complete
Study complete
Trial overview
Official title: An International, Randomized, Double-Blind Study to Compare the Safety and Efficacy of MALARONE (Atovaquone and Proguanil Hydrochloride) Versus Chloroquine and Proguanil Hydrochloride for Chemoprophylaxis Against Malaria in Non-Immune Travelers
Trial description: An International, Randomized, Double-Blind Study to Compare the Safety and Efficacy of MALARONE (Atovaquone and Proguanil Hydrochloride) Versus Chloroquine and Proguanil Hydrochloride for Chemoprophylaxis Against Malaria in Non-Immune Travelers
Primary purpose:
Not applicable
Trial design:
Not applicable
Masking:
Not applicable
Allocation:
Not applicable
Primary outcomes:
Not applicable
Secondary outcomes:
Not applicable
Interventions:
Not applicable
Enrollment:
Not applicable
Primary completion date:
Not applicable
Observational study model:
Not applicable
Time perspective:
Not applicable
Clinical publications:
Abstract: Atovaquone/proguanil versus mefloquine (mfq) or chloroquine/proguanil (cip) in randornised, double-blind clinical trials of malaria prophylaxis in non-immune travelers. D. OVERBOSCH, PD. CLARKE2 B. HOGH U. BIENZLE H. SCHILTHU1S R. H. BEHRENS H. D. NOTHDURFT D. CAMUS K. C. KAIN D. SHAVVN. S. ROSKELL J. D. CHULAY 40th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) 9/17/2000 Toronto, ON; Canada
Abstract: Tolerance, compliance and acceptance of malaroneâ® and savarineâ® for malaria chemoprophylaxis in travellers. Camus, D. 1, Masson, V. 2, Inglebert, P. 2, and Dutoit, E. 1 11th International Congress on Infectious Diseases (ICID) 3/4/2004 Cancun; Mexico
Hogh B. Clarke PD. Camus D. Nothdurft HD. Overbosch D. Gunther M. Joubert I. Kain KC. Shaw D. Roskell NS. Chulay JD. Malarone International Study Team. Atovaquone-proguanil versus chloroquine-proguanil for malaria prophylaxis in non-immune travellers: a randomised, double-blind study. Malarone International Study Team. Lancet. 356:1888-94, 2000.
Medical condition
Malaria
Product
atovaquone/proguanil
Collaborators
Not applicable
Study date(s)
April 1999 to January 2000
Type
Not applicable
Phase
3
Participation criteria
Sex
Not applicable
Age
Not applicable
Accepts healthy volunteers
Not applicable
Inclusion and exclusion criteria
Trial location(s)
This study does not involve prospective enrollment of participants.
Study documents
Scientific result summary
Available language(s): English
If you wish to request for full study report, please contact - [email protected]
Results overview
Not applicable
Recruitment status
Study complete
Actual primary completion date
Not applicable
Actual study completion date
2000-31-01
Plain language summaries
Plain language summaries of clinical trial results for Phase 2-4 clinical trials that were initiated on or after January 2022 will be posted by GSK within one year following study completion.
Additional information about the trial
Not applicable
Participate in clinical trial
Access to clinical trial data by researchers
Visit website