Last updated: 11/07/2018 16:56:53
Double-blind, double-dummy, randomized, parallel group comparison of the efficacy and safety of fluticasone proprionate aqueous nasal spray vs encapsulated loratadine tablets vs a combination of fluticasone proprionate and loratidine vs placebo for two weeks in subjects with seasonal allergic rh ...
Clinicaltrials.gov ID
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EudraCT ID
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EU CT Number
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Trial status
Study complete
Study complete
Trial overview
Official title: Double-blind, double-dummy, randomized, parallel group comparison of the efficacy and safety of fluticasone proprionate aqueous nasal spray vs encapsulated loratadine tablets vs a combination of fluticasone proprionate and loratidine vs placebo for two weeks in subjects with seasonal allergic rh ...
Trial description: Double-blind, double-dummy, randomized, parallel group comparison of the efficacy and safety of fluticasone proprionate aqueous nasal spray vs encapsulated loratadine tablets vs a combination of fluticasone proprionate and loratidine vs placebo for two weeks in subjects with seasonal allergic rh ...
Primary purpose:
Not applicable
Trial design:
Not applicable
Masking:
Not applicable
Allocation:
Not applicable
Primary outcomes:
Not applicable
Secondary outcomes:
Not applicable
Interventions:
Not applicable
Enrollment:
Not applicable
Primary completion date:
Not applicable
Observational study model:
Not applicable
Time perspective:
Not applicable
Clinical publications:
Bowers B, Cox F, Howland W, Cook C, Westlund R, Rogenes P. Superior impact of intranasal fluticasone versus loratadine on work, home and leisure activities affected by SAR. J Allergy Clin Immunol 1997;99 (No. 1, Part 2):S439 (abstract)
Cook CK, Rickard KA, Westlund R. Onset of action of fluticasone propionate aqueous nasal spray (FP). J Allergy Clin Immunol 1999;103 (No. 1 Part 2):S114 (abstract)
Cook CK. The efficacy and safety of fluticasone propionate (FP) aqueous nasal spray and loratadine (LOR), alone and in combination, in the treatment of seasonal allergic rhinitis (SAR). J Allergy Clin Immunol 1997;99(No. 1, Part 2):S439
Cox FM, Bowers BW, Ratner PH, Cook CK, Westlund R, Rogenes PR. Patient-rated overall treatment satisfaction and effectiveness for fluticasone propionate aqueous nasal spray (FP) and loratadine (LOR), alone and in combination. Ann of Allergy, Asthma, and Immunol 1997;78(1): 127 (abstract)
DeWester J, Philpot E, Westlund RE, Cook CK, Rickard KA. The efficacy of intranasal Fluticasone Propionate in the relief of ocular symptoms associated with seasonal allergic rhinitis. Allergy and Asthma Proc 2003;24(5):331-337.
Goodwin B, Bowers B, Hampel F, Cook C, Westlund R, Cox F. Superior improvement in disease- specific quality of life for SAR patients receiving intranasal fluticasone versus loratadine tablets. J Allergy Clin Immunol 1997;99(No. 1, Part 2):S270 (abstract)
Howard K, Bowers B, Cook CK, Westlund R. Evaluation of patient and cost-effectiveness outcomes of intranasal fluticasone versus loratadine tablets versus their use in combination. J Allergy Clin Immunol 2000, 105(1):S212-213 (abstract)
Howard KB, Bowers BW, Cook CK, Westlund R, Rickard K. Intranasal Fluticasone, Loratadine Tablets, and Their Use in Combination: Evaluation of Economic and Humanistic Outcomes. Drug Benefit Trends 2001;13(10):45-52
Meltzer EO, Rickard KA, Westlund RE, Cook CK. Onset of the therapeutic effect of fluticasone propionate aqueous nasal spray. Ann of Allergy, Asthma, and Immunology 2001;86(3):286-291
Philpot E, Toler T, Rickard K. The enhancement of effect by an intranasal placebo spray on the efficacy of an oral allergy tablet comparator. J of the World Allergy Org Abstracts of the WAO Congress-XVIII ICACI Sept 2003(Suppl 1) (abstract) Ratner PH, van Bavel JH, Martin BG, Hampel FC, Howland WC, Rogenes PR, Westlund R,
Ratner PH, van Bavel JH, Martin BG, Hampel FC, Howland WC, Rogenes PR, Westlund RE, Bowers BW, Cook CK. A comparison of fluticasone propionate aqueous nasal spray and loratadine, alone and in combination, for the treatment of seasonal allergic rhinitis. J Fam Pract 1998;47118-125
Westlund RE, Cook CK, Philpot E, Sanjar K. Fluticasone Propionate Aqueous Nasal Spray 200 MG Once Daily Provides Relief of the Ocular Symptoms Associated with Seasonal Allergic Rhinitis. J Allergy Clin Immunol, 2001;107(2):S158 (abstract)
van Bavel JH, Ratner PH, Nayak AS, Shulan D, Reed KD, Rogenes PR, Cook CK. Ocular efficacy and clinician overall evaluation of intranasal fluticasone propionate (FP) versus loratadine (LOR) in seasonal allergic rhinitis (SAR). Ann of Allergy, Asthma, and Immunol 1997;78(1):128
Inclusion and exclusion criteria
Trial location(s)
This study does not involve prospective enrollment of participants.
Study documents
Scientific result summary
Available language(s): English
If you wish to request for full study report, please contact - [email protected]
Results overview
Not applicable
Recruitment status
Study complete
Actual primary completion date
Not applicable
Actual study completion date
1996-01-02
Plain language summaries
Plain language summaries of clinical trial results for Phase 2-4 clinical trials that were initiated on or after January 2022 will be posted by GSK within one year following study completion.
Additional information about the trial
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