Early Bactericidal Activity, Safety & Tolerability of Oral GSK3036656 in a dual Combination With Novel and Established Antitubercular Agents, or Standard of Care in adults with Rifampicin susceptible Pulmonary Tuberculosis

Participants were 18 to 65 years of age inclusive, at the time of signing the informed consent.

• Participants had: 1. A new episode of untreated, rifampicin-susceptible pulmonary tuberculosis (TB) 2. A chest X-ray picture consistent with pulmonary TB 3. At least one sputum sample positive on direct microscopy for acid-fast bacilli (at least 1+ on the International Union Against Tuberculosis and Lung Disease [IUATLD]/World Health Organization [WHO] scale) or positive on a molecular test (at least medium positive for MTB on Xpert MTB/Rif) 4. A normal echocardiogram, or an echocardiogram with normal left ventricular function with at most trace to mild valvular regurgitation, and no valvular stenosis 5. A creatinine clearance greater than or equal to (>=) 90 mL/minute (Cockcroft-Gault formula)
• Male participants were eligible to participate if they agreed to barrier precautions until 90 days after the last dose.
• A female participant was eligible to participate if she was not pregnant or breastfeeding and was a woman of non-childbearing potential (WONCBP) or a woman of childbearing potential (WOCBP) using a highly effective contraceptive method. A WOCBP had to have a negative urine or serum pregnancy test, as required by local regulations, before the first dose of study intervention. Only participants who were at least 25 years of age, and females of non-childbearing potential, were eligible for the positron emission tomography-computed tomography (PET-CT) assessments.
• Participants were capable of giving signed informed consent.

There was evidence of a clinically significant condition or abnormality (as judged by the Investigator) (other than the indication being studied) that might have compromised safety or the interpretation of trial efficacy or safety endpoints.

• There was clinically significant evidence of extrathoracic TB, as judged by the Investigator.
• QTc interval corrected for heart rate by Fridericia's formula (QTcF) was greater than (>) 450 milliseconds (msec).
• There was arterial hypertension with systolic BP >=160 mm Hg or diastolic BP >=100 mm Hg. Participants with well-controlled hypertension could be included if they were using amlodipine for the duration of the study.
• Participants had vitiligo.
• Participants were receiving QT-prolonging drugs, including but not limited to fluoroquinolones, macrolides, and clofazimine.
• HIV-infected participants who: 1. had a cluster of differentiation (CD)4+ count <350 cells/microliters; 2. had received antiretroviral therapy medication within the last 30 days; 3. had received oral or intravenous antifungal medication within the last 30 days; 4. or had an acquired immunodeficiency syndrome (AIDS)-defining opportunistic infection or malignancy in the last 12 months (except pulmonary TB).
• Hepatitis B surface antigen (HBsAg) was present, or the Hepatitis C antibody test result at screening was positive.
• Participants had diabetes (Type 1 or 2), point-of-care glycated hemoglobin (HbA1c) above 6.5%, or random glucose over 11.1 millimoles (mmol)/L.
• There were diseases or conditions in which the use of delamanid or bedaquiline was contraindicated.
• Participants had abnormal laboratory values at screening, as graded by the enhanced Common Terminology Criteria for Adverse Events (CTCAE version 5, 2017).