Last updated: 11/03/2018 22:46:03

Heat, eat, compete: Investigating the application of localised heating on muscle glycogen

GSK study ID
204749
See study documents
Clinicaltrials.gov ID
Not applicable
EudraCT ID
Not applicable
EU CT Number
Not applicable
Trial status
Study complete
Study complete
Overview
Eligibility
Locations
Study documents
Results summary
Plain language summaries
Additional information

Trial overview

Official title: Heat, eat, compete: Investigating the application of localised heating on muscle glycogen
Trial description: Muscle glycogen is a rate limiter to endurance performance. It is common practice for endurance athletes to undertake a form of carbohydrate loading prior to a major event to enhance pre exercise muscle glycogen levels. Some new research has demonstrated that localised heating of a muscle group post exercise can enhance the rate to carbohydrate repletion. This has not been investigated in a rested state pre exercise. Thus the study is designed to investigate the impact localised heating has on muscle glycogen synthesis at rest. The participant will undertake a 24 hour period of carbohydrate loading prior to visiting the lab. During the trial the participant will have one leg heated, with the other leg exposed to ambient conditions. A bilateral muscle biopsy will be collected pre and post heating to quantify muscle glycogen.
Primary purpose:
Other
Trial design:
Parallel Assignment
Masking:
None (Open Label)
Allocation:
Randomized
Primary outcomes:

Muscle glycogen content.

Timeframe: Baseline to 120 min

Secondary outcomes:

Validity (correlation and agreement) between the biopsy and ultra sound muscle glycogen quantification methods.

Timeframe: Baseline to 120 minutes

Interventions:
  • Other: Room temperature
  • Procedure: Heated Trousers
    • Enrollment:
    16
    Primary completion date:
    Not applicable
    Observational study model:
    Not applicable
    Time perspective:
    Not applicable
    Clinical publications:
    Not applicable
    Medical condition
    Sports Nutritional Sciences
    Product
    lidocaine
    Collaborators
    Not applicable
    Study date(s)
    June 2015 to October 2015
    Type
    Interventional
    Phase
    Not applicable

    Participation criteria

    Sex
    Female & Male
    Age
    18 - 35 Year
    Accepts healthy volunteers
    yes
    • Capable of understanding, willing to provide signed and dated copy of informed consent form.
    • Males and females between ages of 18-35 years.
    • Female who is pregnant, intending to become pregnant, or breast feeding.
    • Use of concomitant medication known to be over the counter (OTC) analgesics (24 hours prior to first assessment visit).
    Inclusion and exclusion criteria
    Inclusion criteria:
    • Capable of understanding, willing to provide signed and dated copy of informed consent form. -Males and females between ages of 18-35 years. -BMI should be between 18.0-24.9 (kg/m2) inclusive. -Good in general and mental health with no clinically significant and relevant abnormalities in medical history in the opinion of the investigator or medically qualified designee. -Must be physically active and exercise at a moderate/high intensity greater than (>) 3 times per week for > 30 minutes (min) at a time with no chronic illness and currently free from acute illness. -Ability and willingness to follow all study procedures and successfully complete the study.
    Exclusion criteria:
    • Female who is pregnant, intending to become pregnant, or breast feeding. -Use of concomitant medication known to be over the counter (OTC) analgesics (24 hours prior to first assessment visit). -Known or suspected intolerance or hypersensitivity to the study materials or any of -their stated ingredients. -Has a history of or current evidence (within last 5 years) of abuse of alcohol or other substance. -Vegetarian/vegan or follows any other diet regime excludes certain food groups. -Consuming nutritional supplements in the 48 hours pre trial.

    Trial location(s)

    This study does not involve prospective enrollment of participants.

    Study documents

    Scientific result summary
    Available language(s): English
    Download document(s)

    If you wish to request for full study report, please contact - [email protected]

    Results overview

    Refer to study documents

    Recruitment status
    Study complete
    Actual primary completion date
    Not applicable
    Actual study completion date
    2015-28-10

    Plain language summaries

    Plain language summaries of clinical trial results for Phase 2-4 clinical trials that were initiated on or after January 2022 will be posted by GSK within one year following study completion.

    Additional information about the trial

    Additional information
    Not applicable
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