Indirect Comparison of Albiglutide and Exenatide QW using the Bucher method

Trial description: An indirect comparison of efficacy on blood glucose control, as measured by change from baseline in HbA1c, with albiglutide 50mg once weekly and exenatide 2mg once weekly. The objective is to determine whether albiglutide 50mg and exenatide 2mg are of comparable efficacy. The indirect comparison will be conducted using two studies: HARMONY 7, a 32-week, randomised, open-label study in adults with type 2 diabetes inadequately controlled on oral therapy, comparing albiglutide 50mg once weekly and liraglutide 1.8mg once daily; and DURATION 6: a 26 week, open-label, randomised study in adults with type 2 diabetes uncontrolled with oral antihyperglycaemic drugs, comparing once weekly exenatide 2mg and once-daily liraglutide 1.8 mg. The analysis will be conducted using the Bucher method, a technique for indirectly comparing two treatments that have both been compared to a third treatment. In this case, liraglutide 1.8mg once daily is the common comparator.