Last updated: 11/07/2018 11:44:20
A proof of concept study to assess effect of Fluticasone furoate (FF)/Levocabastine fixed dose combination (FDC) compared with Levocabastine and FF alone in subjects with allergic rhinitis (AR)
EudraCT ID
EU CT Number
Not applicable
Trial status
Study complete
Study complete
Trial overview
Official title: A randomised, double-blind, placebo-controlled, 3 way, incomplete block cross over study in subjects with allergic rhinitis to assess the effect of once daily single and repeat doses of intranasal Fluticasone furoate/Levocabastine fixed dose combination (FDC) relative to Levocabastine and Fluticasone furoate alone on the onset and magnitude of symptoms of rhinitis in an allergen challenge chamber
Trial description: This study will be a randomised, double blind, placebo controlled, 3-way, incomplete block crossover study to evaluate the effect of single and repeat doses of levocabastine, FF, placebo and a FDC of FF/levocabastine administration in AR subjects. The total expected study duration for each individual participating in the study will be a maximum of up to 20 weeks (including the screening and follow-up). This will be a three period study and subjects will be assigned to a sequence of three treatments. There will be a wash-out period of 14-28 days between two treatment periods. The rational for this study is to demonstrate proof of concept with the FDC of FF and levocabastine compared with each of the components administered alone.
Primary purpose:
Treatment
Trial design:
Crossover Assignment
Masking:
Double (Participant, Investigator)
Allocation:
Randomized
Primary outcomes:
Weighted mean of the total nasal symptom score (TNSS) (0-4) hours (h) post start of allergen chamber challenge on Day 8 of each treatment period
Timeframe: Day 8 of each treatment period (up to 80 days)
Secondary outcomes:
Weighted mean of the magnitude of symptom relief on total nasal symptom score (TNSS) (2-4) hours (h) post start of allergen chamber challenge on Day 1 of each treatment period
Timeframe: Day 1 of each treatment period (up to 80 days)
Weighted mean of the magnitude of symptom relief on total ocular symptom score (TOSS) (2-4) hours (h) post start of allergen chamber challenge on Day 1 of each treatment period
Timeframe: Day 1 of each treatment period (up to 80 days)
Weighted mean of the total ocular symptom score (TOSS) (0-4) hours (h) post start of allergen chamber challenge on Day 8 of each treatment period
Timeframe: Day 8 of each treatment period (up to 80 days)
Interventions:
Enrollment:
71
Primary completion date:
2014-20-02
Observational study model:
Not applicable
Time perspective:
Not applicable
Clinical publications:
R. D. Murdoch, P. Bareille, D. Ignar, S. R. Miller, A. Gupta, R. Boardley, P. Zieglmayer, R. Zieglmayer, P. Lemel,F. Horak. The improved efficacy of a fixed dose combination of fluticasone furoate and levocabastine relative to the individual components in the treatment of allergic rhinitis. Clin Exp Allergy. 2015;45(8):1346-1355.
Medical condition
Rhinitis, Allergic, Perennial and Seasonal
Product
fluticasone furoate, fluticasone furoate/levocabastine, levocabastine
Collaborators
Not applicable
Study date(s)
October 2013 to February 2014
Type
Interventional
Phase
2
Participation criteria
Sex
Female & Male
Age
18 - 65 years
Accepts healthy volunteers
No
- Diagnosis of AR, as determined by the presence of rhinitis symptoms that last for several months per year, for more than 1 year and are not attributed to infections or nasal abnormalities.
- Subjects have a TNSS score of >=6 during the screening allergen challenge chamber.
- Nasal abnormalities likely to affect the outcome of the study, that is nasal septal perforation, nasal polyps, sinusitis other nasal malformations.
- History of frequent nose bleeds
Inclusion and exclusion criteria
Inclusion criteria:
- Diagnosis of AR, as determined by the presence of rhinitis symptoms that last for several months per year, for more than 1 year and are not attributed to infections or nasal abnormalities.
- Subjects have a TNSS score of >=6 during the screening allergen challenge chamber.
- Subjects have a positive skin prick test (wheal >=4 millimeter [mm]) for seasonal pollen at or within the 12 months preceding the screening visit.
- Subjects have a positive radioallergosorbent test (RAST) (>=class 2) for seasonal pollen at or within the 12 months preceding the screening visit.
- There are no conditions or factors that would make the subject unlikely to be able to stay in the chamber for 5 hours.
- Male/females between 18 and 65 years of age inclusive, at the time of signing the informed consent.
- Healthy as determined by a responsible and experienced physician, based on a medical evaluation including medical history, physical examination and laboratory tests. A subject with a clinical abnormality or laboratory parameter(s) which is/are not specifically listed in the inclusion or exclusion criteria, outside the reference range for the population being studied may be included only if the Investigator agree and document that the finding is unlikely to introduce additional risk factors and will not interfere with the study procedures.
- Body weight >=50 kg and body mass index (BMI) within the range 19–30 kilogram per meter suare (kg/m^2) (inclusive).
- A female subject is eligible to participate if she is of: Non-childbearing potential defined as pre-menopausal females with a documented tubal ligation or hysterectomy [for this definition, “documented” refers to the outcome of the investigator's/designee’s review of the subject's medical history for study eligibility, as obtained via a verbal interview with the subject or from the subject’s medical records]; or postmenopausal defined as 12 months of spontaneous amenorrhea (in questionable cases a blood sample with simultaneous follicle stimulating hormone [FSH] >40 milli international unit per milliliter (MIU/milliliter [mL]) and estradiol <40 picogram per milliliter[pg/mL] (<147 picomole per liter [pmol/L]) is confirmatory). Child-bearing potential with negative pregnancy test as determined by urine beta-human chorionic gonadotropin (β-hCG) test at screening or prior to dosing and;
- Agrees to use one of the contraception methods for an appropriate period of time (as determined by the product label or investigator) prior to the start of dosing to sufficiently minimize the risk of pregnancy at that point. Female subjects must agree to use contraception until 1 week post-last dose
- Capable of giving written informed consent, which includes compliance with the requirements and restrictions listed in the consent form.
- Subjects should be non-smokers, which for this study is defined as having smoked <10 packs per year in their lifetime, and have not smoked in the 6 months prior to the screening visit.
- alanine aminotransferase (ALT), alkaline phosphatase and bilirubin <=1.5x upper limit of normal (ULN) (isolated bilirubin >1.5xULN is acceptable if bilirubin is fractionated and direct bilirubin <35%).
- Based on single or averaged corrected QT interval (QTc) values of triplicate electrocardiogram (ECGs) obtained over a brief recording period: Fridericia’s QTC (QTcF) <450 milliseconds (msec).
Exclusion criteria:
- Nasal abnormalities likely to affect the outcome of the study, that is nasal septal perforation, nasal polyps, sinusitis other nasal malformations.
- History of frequent nose bleeds
- Patients with rhinitis medicamentosa
- Current or chronic history of liver disease, or known hepatic or biliary abnormalities (with the exception of Gilbert's syndrome or asymptomatic gallstones).
- Significant renal impairment, which based on the opinion of the investigator, would preclude the subjects participation in the study.
- History of regular alcohol consumption within 6 months of the study defined as:
- An average weekly intake of >21 units for males or >14 units for females. One unit is equivalent to 8 gram of alcohol: a half-pint (~240 mL) of beer, 1 glass (125 mL) of wine or 1 (25 mL) measure of spirits.
- History of sensitivity to any of the study medications, or components thereof or a history of drug or other allergy that, in the opinion of the investigator or GSK Medical Monitor, contraindicates their participation.
- A positive pre-study Hepatitis B surface antigen or positive Hepatitis C antibody result within 3 months of screening
- A positive pre-study drug/alcohol screen.
- A positive test for human immunodeficiency virus (HIV) antibody.
Trial location(s)
Study documents
Clinical study report
Available language(s): English
Scientific result summary
Available language(s): English
Protocol
Available language(s): English
If you wish to request for full study report, please contact - [email protected]
Results overview
Results posted on ClinicalTrials.gov
Recruitment status
Study complete
Actual primary completion date
2014-20-02
Actual study completion date
2014-20-02
Plain language summaries
Plain language summaries of clinical trial results for Phase 2-4 clinical trials that were initiated on or after January 2022 will be posted by GSK within one year following study completion.
Additional information about the trial
Participate in clinical trial
Additional information
Researchers can use this site to request access to anonymised patient level data and/or supporting documents from clinical studies to conduct further research.
Click hereAccess to clinical trial data by researchers
Visit website