GSK239512 DDI Study

1. A positive pre-study Hepatitis B surface antigen or positive Hepatitis C antibody result within 3 months of screening 2. Current or chronic history of liver disease, or known hepatic or biliary abnormalities (with the exception of Gilbert's syndrome or asymptomatic gallstones). 3. A positive pre-study drug/alcohol screen. 4. A positive test for Human Immunodeficiency Virus (HIV) antibody. 5. History of alcohol consumption exceeding, on average, 21 drinks/week for men (1 drink = 100 mL of wine or 240 mL of beer or 30 mL of hard liquor in Australia) within 6 months of the first dose of study medication. 6. History of smoking cigarettes or using tobacco products or any nicotine-containing products (including nicotine patches) within 3 months of screening. 7. The subject has participated in a clinical trial and has received an investigational product within 30 days or 5 half lives (whichever is longer) prior to the first dosing day in the current study. 8. Exposure to more than four new chemical entities within 12 months prior to the first dosing day. 9. Unable to refrain from the use of prescription or non-prescription drugs, including vitamins, herbal and dietary supplements (including St John’s Wort) within 7 days (or 14 days if the drug is a potential enzyme inducer) or 5 half-lives (whichever is longer) prior to the first dose of study medication, unless in the opinion of the Investigator and GSK Medical Monitor the medication will not interfere with the study procedures or compromise subject safety. 10. History of sensitivity to ketoconazole, or to the excipients contained in GSK239512 or Nizoral, or a history of drug or other allergy that, in the opinion of the investigator or GSK Medical Monitor, contraindicates their participation. 11. Where participation in the study would result in donation of blood or blood products in excess of 500 mL within a 56 day period. 12. Unwillingness or inability to follow the procedures outlined in the protocol. 13. Subject is mentally or legally incapacitated. 14. Have used the following medications within the last 30 days or 5 half-lives (whichever is longer) prior to screening and are not able to discontinue use throughout participation in the clinical trial:

• Any CNS stimulants (e.g., modafinil, dexamphetamine, methylphenidate).
• Known potent P-glycoprotein inhibitors (e.g. itraconazole, ketoconazole, cyclosporin, loperamide, diltiazem, verapamil, spironolactone, quinidine, bepridil, quinine, carvedilol).
• Known potent inhibitors or inducers of the CYP3A4 enzyme (see Appendix 3).
• CNS-penetrant antihistamines (e.g. bromopheniramine, chlorpheniramine, clemastine, diphenhydramine, hyrdoxyzine)
• Any other medicines that are contraindications of Nizoral (see Appendix 4). 15. Unable to refrain from consumption of red wine, seville oranges, grapefruit or grapefruit juice from 7 days prior to the first dose of study medication. 16. The subject has a history of significant psychiatric illness. 17. Presence or history of hallucinations that, in the judgement of the investigator, may increase the safety risk to the subject. 18. At risk of suicide, as indicated by:
• A documented history of attempted suicide or significant suicidal ideation during the 6 months preceding the screening visit, OR
• If in the investigator’s judgment the subject is at risk of a suicide attempt based on the screen visit assessment, including the C-SSRS. 19. Diagnosis of any type epilepsy 20. Night shift workers within 4 weeks of first dosing 21. Presence of significant and routine sleep disturbance that has a negative impact on quality of life that, in the judgement of the investigator, may increase the risk of tolerability issues during dose escalation.
• Examples of significant sleep disturbances may be: severe insomnia, nocturnal wandering, confusion, disorientation, agitation, or vivid dreams.