Last updated: 11/07/2018 11:18:23
Drug Treatment Patterns and Survival Among Patients with Metastatic or Recurrent Soft Tissue Sarcoma (m/rSTS) Refractory to at Least One Prior Therapy
Clinicaltrials.gov ID
Not applicable
EudraCT ID
Not applicable
EU CT Number
Not applicable
Trial status
Study complete
Study complete
Trial overview
Official title: Drug Treatment Patterns and Survival Among Patients with Metastatic or Recurrent Soft Tissue Sarcoma (m/rSTS) Refractory to at Least One Prior Therapy
Trial description: Limited clinical data are available about the care of patients with metastatic/recurrent soft tissue sarcoma (m/rSTS) and real-world practice patterns. This study evaluates drug treatment patterns and outcomes in m/rSTS subjects following failure of prior chemotherapy.The primary purpose of this study is to evaluate drug treatment patterns in m/rSTS subjects following failure of prior chemotherapy, based on data from a referral academic cancer center in the United States. Data from medical records consented for research use will be retrospectively reviewed at Dana-Farber Cancer Institute for subjects with m/rSTS who were aged 18 years or older, commenced second-line systemic therapy between 1 January 2000 and 2 April 2011, had confirmed disease progression on or after first-line therapy and had at least 3 months of observation.The study design is a retrospective, observational chart review.
Primary purpose:
Not applicable
Trial design:
Not applicable
Masking:
Not applicable
Allocation:
Not applicable
Primary outcomes:
Treatment Patterns
Timeframe: from diagnosis to death or end of chart record
Secondary outcomes:
Progression-free survival
Timeframe: from diagnosis to death or end of chart record
Overall survival
Timeframe: from diagnosis to death or end of chart record
Interventions:
Enrollment:
99
Primary completion date:
Not applicable
Observational study model:
Cohort
Time perspective:
Retrospective
Clinical publications:
Wagner M, Amodu L, Duh M, et al.A retrospective chart review of drug treatment patterns and clinical outcomes among patients with metastatic or recurrent soft tissue sarcoma refractory to one or more prior chemotherapy treatments.BMC Cancer.2015;15(175)
- A diagnosis of m/rSTS
- Age 18 years or older
- Treatment with pazopanib
Inclusion and exclusion criteria
Inclusion criteria:
- A diagnosis of m/rSTS
- Age 18 years or older
- Commenced second-line systematic therapy between 1 January 2000 and 2 April 2011
- Confirmed disease progression on or after first-line therapy
- At least 3 months of observed data following commencement of second-line therapy
Exclusion criteria:
- Treatment with pazopanib
Trial location(s)
This study does not involve prospective enrollment of participants.
Study documents
Scientific result summary
Available language(s): English
If you wish to request for full study report, please contact - [email protected]
Results overview
Refer to study documents
Recruitment status
Study complete
Actual primary completion date
Not applicable
Actual study completion date
2012-04-06
Plain language summaries
Not applicable. GSK’s transparency policy provides for Plain Language Summaries for Interventional studies.
Additional information about the trial
Not applicable
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