Last updated: 11/07/2018 08:34:04
A Meta Analysis to compare the efficacy of Acyclovir 3% ophthalmic ointment to Idoxuridine in curing herpes keratitis after 7-days of treatment
Clinicaltrials.gov ID
Not applicable
EudraCT ID
Not applicable
EU CT Number
Not applicable
Trial status
Finalized
Finalized
Trial overview
Official title: A Meta Analysis to compare the efficacy of Acyclovir 3% ophthalmic ointment to Idoxuridine in curing herpes keratitis after 7-days of treatment
Trial description: Acyclovir 3% ophthalmic ointment has been evaluated for the treatment of herpes simplex keratitis (HSK) in many clinical trials and has demonstrated healing rates superior to idoxuridine (Dendrid®) and comparable to trifluridine (Viroptic®) (Wilhelmus, 2009). Both idoxuridine and trifluridine are currently approved in the United States for the treatment of herpes simplex keratitis.The objective of this meta analysis is to to compare the efficacy of acyclovir 3% ophthalmic ointment to idoxuridine in curing herpes keratitis after 7-days of treatment. The null hypothesis is that the efficacy of acyclovir ophthalmic ointment is similar to idoxuridine and the alternative is that it is superior to idoxuridine
Primary purpose:
Not applicable
Trial design:
Not applicable
Masking:
Not applicable
Allocation:
Not applicable
Primary outcomes:
healing
Timeframe: 7 days
Secondary outcomes:
Not applicable
Interventions:
Drug: acyclovir
Drug: idoxuridine
Enrollment:
1
Observational study model:
Other
Primary completion date:
Not applicable
Time perspective:
Prospective
Clinical publications:
Diane E. Balderson,Gengqian Cai, Michael A. Fries, David M. Kleinman, Megan M. McLaughlin,Trupti M. Trivedi, John I. Wurzelmann, Sheila B. Young. A systematic review and meta-analysis to compare the efficacy of acyclovir 3% ophthalmic ointment to idoxuridine in curing herpetic keratitis by Day 7 of treatment. BMC Ophthalmol. 2015;15:42.
Medical condition
Herpes Simplex, Ocular
Product
aciclovir
Collaborators
Not applicable
Study date(s)
October 2010 to April 2012
Type
Observational
Phase
Not applicable
Participation criteria
Sex
Female & Male
Age
1 - 100 Year
Accepts healthy volunteers
none
- N/A
- N/A
Inclusion and exclusion criteria
Inclusion criteria:
- N/A
Exclusion criteria:
- N/A
Trial location(s)
No location data available.
Study documents
Clinical study report
Available language(s): English
Scientific result summary
Available language(s): English
If you wish to request for full study report, please contact - [email protected]
Results overview
Refer to study documents
Recruitment status
Finalized
Actual primary completion date
Not applicable
Actual study completion date
2012-09-04
Plain language summaries
Not applicable. GSK’s transparency policy provides for Plain Language Summaries for Interventional studies.
Additional information about the trial
Not applicable
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