Study to evaluate the safety and immunogenicity of an investigational pneumococcal vaccine in the elderly population

•Subjects who the investigator believes that they can and will comply with the requirements of the protocol. •A male or female between 65 and 85 years of age at the time of the first vaccination. •Written informed consent obtained from the subject.

•Previous vaccination against Streptococcus pneumoniae. •Acute or chronic, clinically significant pulmonary, cardiovascular, hepatic or renal functional abnormality, as determined by physical examination or laboratory tests. •Acute disease at the time of enrolment. •History of documented radiologically confirmed pneumonia within 3 years prior to first vaccination. •Any confirmed or suspected immunosuppressive or immunodeficient condition, based on medical history and physical examination (no laboratory testing required). •History of allergic disease or reactions likely to be exacerbated by any component of the vaccine(s). •Current or history of Parkinson disease, Alzheimer disease, stroke, dementia or any serious neurologic or mental disorders. •All malignancies (excluding non-melanic skin cancer) and lymphoproliferative disorders diagnosed or treated actively during the past 5 years. •Subjects with documented anaemia or iron-deficiency. •Chronic administration (defined as more than 14 days) of immunosuppressants or other immune-modifying drugs within 3 months prior to the first vaccine dose. •Planned administration/ administration of a vaccine not foreseen by the study protocol within 2 weeks of the first dose of vaccine(s) with the exception of a Flu vaccine which can be administered at least 1 week preceding the first dose of vaccine(s) or 1 month after the first dose of the vaccine(s). •Use of any investigational or non-registered product (drug or vaccine) other than the study vaccine(s) within 30 days preceding the first dose of study vaccine, or planned use during the study period. •Administration of immunoglobulins and/or any blood products within three months preceding the first dose of study vaccine or planned administration during the study period. •History of administration of an experimental/licensed vaccine containing MPL or QS21. •History of chronic alcohol consumption and/or drug abuse.