Last updated: 11/07/2018 01:08:18
A six-month, double-blind, placebo-controlled, multicenter dose-ranging comparison of oral carvedilol b.i.d. in patients with congestive heart failure, NYHA Class II-IV.
Clinicaltrials.gov ID
Not applicable
EudraCT ID
Not applicable
EU CT Number
Not applicable
Trial status
Study complete
Study complete
Trial overview
Official title: A six-month, double-blind, placebo-controlled, multicenter dose-ranging comparison of oral carvedilol b.i.d. in patients with congestive heart failure, NYHA Class II-IV.
Trial description: A six-month, double-blind, placebo-controlled, multicenter dose-ranging comparison of oral carvedilol b.i.d. in patients with congestive heart failure, NYHA Class II-IV.
Primary purpose:
Not applicable
Trial design:
Not applicable
Masking:
Not applicable
Allocation:
Not applicable
Primary outcomes:
Not applicable
Secondary outcomes:
Not applicable
Interventions:
Not applicable
Enrollment:
Not applicable
Primary completion date:
Not applicable
Observational study model:
Not applicable
Time perspective:
Not applicable
Clinical publications:
Carvedilol produces dose-related improvements in left ventricular function and survival in subjects with chronic heart failure. mocha investigators. Bristow, M. R., Gilbert, E. M., Abraham, W. T., Adams, K. F., Fowler, M. B., Hershberger, R. E., Kubo, S. H., Narahara, K. A., Ingersoll, H., Krueger, S., Young, S., and Shusterman, N. Circulation 1996; 94(11):2807-16
Effect of carvedilol on left ventricular function and mortality in diabetic versus non-diabetic patients with ischaemic or non-ischaemic dilated cardiomyopathy. M.R. Bristow, E. M. Gilbert VV. T. Abraham K. F. Adams M. B. Fowler R. Hershberger S. H. Kubo K. A. Narahara A. D. Robertson S. Krueger forthe MOCHA Investigators 18th Congress of the European Society of Cardiology 8/25/1996 Birmingham; UK
Multicenter oral carvedilol heart failure assessment (mocha): a six-month dose-response evaluation in class ii-iv patients. Bristow, Michael R MD, Gilbert, Edward M MD, Abraham, William T MD, Adams, Kirkwood F MD, Fowler, Michael B MD, Hersberger, Ray MD, Kubo, Spencer H MD, Narahara, Kenneth A MD, and Ingersoll, Henry MD American Heart Association 68th Scientific Sessions 11/13/1995 Anaheim, CA; USA
Relationships between carvedilol stereoisomer plasma concentrations and ãÿ-receptor occupancies in subjects with chronic heart failure in the multicenter oral carvedilol heart failure assessment (mocha) trial. M.R. Bristow, VV. T. Abraham E. M. Gilbert T. Yoshikowa J. D. Port 18th Congress of the European Society of Cardiology 8/25/1996 Birmingham; UK
Medical condition
Heart failure, Congestive
Product
carvedilol
Collaborators
Not applicable
Study date(s)
January 1993 to January 1995
Type
Not applicable
Phase
3
Participation criteria
Sex
Not applicable
Age
Not applicable
Accepts healthy volunteers
Not applicable
Inclusion and exclusion criteria
Trial location(s)
This study does not involve prospective enrollment of participants.
Study documents
Scientific result summary
Available language(s): English
If you wish to request for full study report, please contact - [email protected]
Results overview
Not applicable
Recruitment status
Study complete
Actual primary completion date
Not applicable
Actual study completion date
1995-31-01
Plain language summaries
Plain language summaries of clinical trial results for Phase 2-4 clinical trials that were initiated on or after January 2022 will be posted by GSK within one year following study completion.
Additional information about the trial
Not applicable
Participate in clinical trial
Access to clinical trial data by researchers
Visit website