Completed

Study Description:

The purpose of this study is to see if fluticasone 500mcg/salmeterol 50mcg can improve the survival of subjects with COPD and also assess the long term safety profile of this drug.

GSK Study ID:

SCO30003


Has Results Document Available
ClinicalTrials.gov Identifier:

NCT00268216


EudraCT Number:

Not Available


Study Overview

Medical Conditions

Chronic Obstructive Pulmonary Disease

Product

fluticasone propionate;fluticasone propionate/salmeterol;salmeterol

Collaborators

N/A


Date

September 2000 to November 2005

Type

Interventional

Phase

3


Gender

Both

Age

40 years - 80 years

Accepts Healthy Volunteers

No


This study has Protocol summary on ClinicalTrial.gov. Click here to learn more.

Locations

  • Central Contact :

    US GSK Clinical Trials Call Center

  • Central Contact Phone:

    877-379-3718

  • Central Contact Email:

    [email protected]

Argentina, Buenos Aires, Buenos Aires 1272Completed
Argentina, Buenos Aires, La Plata 1900Completed
Argentina, Buenos Aires, Vicente López 1602Completed
Australia, New South Wales, Bankstown 22000Completed
Australia, New South Wales, Camperdown 2050Completed
Australia, New South Wales, North Gosford 2250Completed
Australia, South Australia, Adelaide 5000Completed
Australia, South Australia, Toorak Gardens 5065Completed
Australia, Victoria, Frankston 3199Completed
Australia, Victoria, Geelong 3220Completed
Australia, Victoria, Heidelberg 3084Completed
Australia, Victoria, Melbourne 3004Completed
Australia, Victoria, Melbourne 3050Completed
Australia, Western Australia, Nedlands 6009Completed
Austria, Vienna A-1120Completed
Austria, Vienna A-1030Completed
Austria, Vienna A-1210Completed
Austria, Wels A-4600Completed
Belgium, Bruxelles 1180Completed
Belgium, Namur 5000Completed
Belgium, Oostende 8400Completed
Belgium, Orp-Jauche 1350Completed
Belgium, Veurne 8630Completed
Brazil, Rio De Janeiro, Rio de Janeiro 20 551-030Completed
Brazil, Rio De Janeiro, Rio de Janeiro 20221-903Completed
Brazil, Rio De Janeiro, Rio de Janeiro 21941-590Completed
Brazil, Rio Grande Do Sul, Porto Alegre 90035 003Completed
Brazil, Rio Grande Do Sul, Porto Alegre 40110-160Completed
Brazil, São Paulo, Santo Andre 09060-670Completed
Brazil, São Paulo, São Paulo 05403-900Completed
Bulgaria, Pleven 5800Completed
Bulgaria, Russe 7000Completed
Bulgaria, Sofia 1431Completed
Bulgaria, Sofia 1202Completed
Bulgaria, Varna 9010Completed
Canada, Alberta, Calgary T2V 1P9Completed
Canada, Alberta, Calgary T2N 4N1Completed
Canada, Alberta, Edmonton T6L 5X8Completed
Canada, British Columbia, Maple Ridge V2X 2L5Completed
Canada, New Brunswick, Saint John E2M 3W5Completed
Canada, Newfoundland and Labrador, Saint John's A1B 3V6Completed
Canada, Ontario, Mississauga L5M 2V8Completed
Canada, Ontario, Mississauga L5A 1N1Completed
Canada, Ontario, Scarborough M1B 4Z8Completed
Canada, Ontario, Thunder Bay P7A 4V7Completed
Canada, Ontario, Toronto M6H 3M2Completed
Canada, Ontario, Windsor N8X 3V6Completed
Canada, Québec, Montreal H2X 2P4Completed
Canada, Québec, Quebec G1S 4L8Completed
Canada, Québec, Sainte-Foy G1V 4G5Completed
Canada, Québec, Sherbrooke J1H 1Z1Completed
Canada, Québec, Sherbrooke J1H 4J6Completed
Chile, Región De La Araucania, Temuco Completed
Chile, Región Metro De Santiago, Santiago 7500691Completed
Chile, Valparaíso, Valparaiso 2341131Completed
China, Beijing 100036Completed
China, Beijing 100039Completed
China, Beijing 100034Completed
China, Beijing 100037Completed
China, Chongqing 400037Completed
China, Shanghai 200025Completed
China, Wangfujing, Beijing 100730Completed
China, Guangdong, Guangzhou 510120Completed
China, Jiangsu, Nanjing 210002Completed
China, Liaoning, Shenyang 110015Completed
China, Shaanxi, Xian 710061Completed
Croatia, Zagreb 10000Completed
Czech Republic, Hradec Kralove 500 05Completed
Czech Republic, Jaromer 551 01Completed
Czech Republic, Ostrava - Fifejdy 728 80Completed
Czech Republic, Praha 5 150 06Completed
Czech Republic, Praha 8 180 81Completed
Czech Republic, Praha 8 182 00Completed
Czech Republic, Tabor 390 19Completed
Denmark, Aarhus C DK-8000Completed
Denmark, Hvidovre 2650Completed
Denmark, Kobenhavn NV 2400Completed
Denmark, Silkenborg DK-8600Completed
Estonia, Kohtal-Jdrve 31 025Completed
Estonia, Tallinn 13419Completed
Estonia, Tartu 51014Completed
Finland, Helsinki 00029Completed
Finland, Helsinki 00290Completed
Finland, Kinkomaa 40930Completed
Finland, Lappeenranta 53130Completed
Finland, Lohja 08200Completed
Finland, Mikkeli 50100Completed
Finland, Oulainen 86300Completed
Finland, Pori 28100Completed
Finland, Vantaa 01400Completed
France, Annonay 07100Completed
France, Avrille 49240Completed
France, Bethune Cedex 62408Completed
France, Bois Guillaume 76230Completed
France, Caen Cedex 14050Completed
France, Chamalières 63400Completed
France, Cholet 49300Completed
France, Corbeil Essonne 91100Completed
France, Ferolles Attilly 77150Completed
France, Grenoble 38000Completed
France, Lille 59800Completed
France, Lomme 59160Completed
France, Marseille Cedex 20 13915Completed
France, Maurepas 78310Completed
France, Meaux 77104Recruiting
France, Nantes 44000Completed
France, Nimes 30900Completed
France, Nimes 30000Completed
France, Paris Cedex 04 75181Completed
France, Saint Quentin 02100Completed
France, Tarbes Cedex 09 65013Completed
France, Toulouse Cedex 9 31059Completed
France, Tours Cedex 1 37000Completed
France, Verdun 55100Completed
Germany, Baden-Wuerttemberg, Schwetzingen 68723Completed
Germany, Berlin, Berlin 10365Completed
Germany, Berlin, Berlin 10178Completed
Germany, Berlin, Berlin 10559Completed
Germany, Berlin, Berlin 13357Completed
Germany, Hessen, Darmstadt 64287Completed
Germany, Hessen, Kassel 34117Completed
Germany, Niedersachsen, Hannover 30167Completed
Germany, Nordrhein-Westfalen, Bielefeld 33602Completed
Germany, Schleswig-Holstein, Bad Segeberg 23795Completed
Greece, Athens 15669Completed
Greece, Chania, Crete 73300Completed
Greece, Heraklion, Crete 71409Completed
Greece, Heraklion, Crete 71110Completed
Greece, Kavala 65403Completed
Greece, Larisa 41110Completed
Greece, Maroussi, Athens 11526Terminated
Greece, N. Efkarpia, Thessaloniki 564 29Completed
Greece, Papagos/Athens 15669Completed
Greece, Patra 26226Completed
Greece, Thessaloniki 54642Completed
Greece, Thessaloniki 57010Completed
Hong Kong, Aberdeen Completed
Hong Kong, Kowloon Completed
Hong Kong, Kwun Tong Completed
Hong Kong, Lai Chi kok Completed
Hong Kong, Tai Po, Completed
Hungary, Budapest 1529Completed
Hungary, Cegléd 2700Completed
Hungary, Dunaujvaros 2400Completed
Hungary, Szolnok 5004Completed
Hungary, Tatabanya 2800Completed
Hungary, Törökbálint 2045Completed
Iceland, Fossvogur. Reykjavic 108Completed
Iceland, Reykjavik 109Completed
Italy, Emilia-Romagna, Ferrara 44100Completed
Italy, Lombardia, Brescia 25123Completed
Italy, Lombardia, Milano 20152Completed
Italy, Lombardia, Sesto San Giovanni (MI) 20099Completed
Italy, Lombardia, Tradate (VA) 21049Completed
Italy, Toscana, Pisa 56124Completed
Italy, Veneto, Bussolengo (VR) 37012Completed
Latvia, Riga LV 1035Completed
Latvia, Riga LV 1038Completed
Lithuania, Kaunas LT-50009Completed
Malaysia, Kuala Lumpur 50586Completed
Malaysia, Kubang Kerian 16150Completed
Malaysia, Kuching 93586Completed
Malaysia, Tanjong Bungah 10450Completed
Mexico, Mexico 14000Completed
Mexico, Mexico, D.F. 06720Completed
Mexico, Jalisco, Guadalajara 44340Completed
Netherlands, ARNHEM 6815 ADCompleted
Netherlands, BILTHOVEN 3723Terminated
Netherlands, BREDA 4819 EVCompleted
Netherlands, DORDRECHT 3317 NMCompleted
Netherlands, EDE 6716 RPCompleted
Netherlands, HEERLEN 6419 PCCompleted
Netherlands, HENGELO 7555 DLCompleted
Netherlands, Hoofddorp 2130 ATCompleted
Netherlands, ROOSENDAAL 4708 AECompleted
Netherlands, TERNEUZEN 4535 PACompleted
Netherlands, UTRECHT 2584 CXCompleted
Netherlands, ZWOLLE 8025 ABCompleted
New Zealand, Auckland 1001Completed
New Zealand, Auckland 1005Completed
New Zealand, Auckland 1701Completed
New Zealand, Hamilton 2001Completed
New Zealand, Tauranga 3001Completed
New Zealand, Wellington 6035Completed
New Zealand, Wellington South 6002Completed
Norway, Alesund 6026Completed
Norway, Bardufoss 9325Completed
Norway, Bergen 5053Completed
Norway, Bodo N-8092Completed
Norway, Harstad N-9480Completed
Norway, Oslo 1150Completed
Norway, Oslo N-0514Completed
Norway, Oslo N-0456Completed
Norway, Oslo N-1054Completed
Norway, Sandvika 1337Completed
Norway, Skien 3722Completed
Norway, Tonsberg N-3117Completed
Norway, Trondheim 7006Completed
Norway, Volda 6100Completed
Pakistan, Lahore Terminated
Philippines, Cebu City 6000Completed
Philippines, Manila 1000Completed
Philippines, Manila Completed
Philippines, Quezon City 1101Completed
Poland, Bialystok 15-276Completed
Poland, Katowice 40-752Completed
Poland, Warszawa 01-138Completed
Poland, Wroclaw 50-449Completed
Poland, Zabrze 41-800Completed
Puerto Rico, Puerto Rico, Ponce 731Completed
Romania, Brasov 2200Completed
Romania, Bucharest 050159Completed
Romania, Bucharest 050098Terminated
Romania, Iasi 700115Completed
Russia, Moscow 105 077Completed
Russia, Moscow 121 359Completed
Russia, Moscow 109240Completed
Singapore, Singapore 169608Completed
Singapore, Singapore 119074Completed
Singapore, Singapore 238869Completed
Singapore, Singapore 308433Completed
Slovakia, Banska Bystrica 974 01Completed
Slovakia, Kralovsky Chlmec 077 01Completed
Slovakia, Nove Zamky 940 34Completed
Slovakia, Partizanske 958 01Completed
South Africa, Cape Town 8001Completed
South Africa, Cape Town 7505Completed
South Africa, Mowbray 7700Completed
South Africa, Pretoria 0040Completed
South Africa, Pretoria Completed
South Africa, KwaZulu- Natal, Durban 4126Completed
Spain, Alicante Completed
Spain, Barakaldo (Vizcaya) 48903Completed
Spain, Barcelona 08035Completed
Spain, Cadiz 11009Completed
Spain, Cartagena 30203Completed
Spain, Elda 03600Completed
Spain, Guadalajara 19002Completed
Spain, La Coruña 15006Terminated
Spain, Madrid 28040Completed
Spain, Madrid 28046Completed
Spain, Orihuela/Alicante 03314Completed
Spain, Santiago De Compostela 15706Terminated
Spain, Unknown Completed
Spain, Valencia 46017Completed
Spain, Vigo/Pontevedra 36200Completed
Spain, Vizcaya 48902Completed
Sweden, BODEN SE-961 64Completed
Sweden, EKSJÖ SE-575 81Completed
Sweden, GÖTEBORG SE-413 45Completed
Sweden, HELSINGBORG SE-252 26Completed
Sweden, HELSINGBORG SE-251 87Completed
Sweden, LIDKÖPING SE-531 85Completed
Sweden, TROLLHÄTTAN SE-461 85Completed
Taiwan, Kaohsiung 80708Completed
Taiwan, Taichung 40705Completed
Taiwan, Tainan 704Completed
Taiwan, Taipei 112Completed
Taiwan, Tau-Yuan County 333Completed
Thailand, Bangkok 10330Completed
Thailand, ChiangMai 50200Completed
Ukraine, Kiev 03680Completed
United Kingdom, London E1 1BBCompleted
United Kingdom, Devon, Exeter EX2 5DWCompleted
United Kingdom, Gloucestershire, Bristol BS16 2EWCompleted
United Kingdom, Lancashire, Liverpool L9 7ALCompleted
United Kingdom, Lancashire, Manchester M8 5RBCompleted
United Kingdom, Northumberland, Newcastle Upon Tyne NE1 4LPCompleted
United Kingdom, Oxfordshire, Headington OX3 7LJCompleted
United States, Alabama, Birmingham 35294-7340Completed
United States, Alabama, Birmingham 35294Completed
United States, Alabama, Birmingham 35235Completed
United States, Alabama, Jasper 35501Completed
United States, Alabama, Mobile 36608Completed
United States, Alabama, Ozark 36360Completed
United States, Arizona, Phoenix 85006Completed
United States, Arizona, Phoenix 85008Completed
United States, Arizona, Phoenix 85008Terminated
United States, Arizona, Scottsdale 85251Completed
United States, California, Berkeley 94705Completed
United States, California, Burbank 91505Completed
United States, California, Encinitas 92024Terminated
United States, California, Fresno 93710Completed
United States, California, Fullerton 92835Completed
United States, California, Long Beach 90822Completed
United States, California, Los Angeles 90048Completed
United States, California, Los Angeles 90033Terminated
United States, California, Rancho Mirage 92270Completed
United States, California, Riverside 92506Completed
United States, California, San Diego 92103-6204Completed
United States, California, San Diego 92103Completed
United States, California, San Diego 92120Completed
United States, California, San Diego 92123Completed
United States, California, San Diego 92117Completed
United States, California, San Francisco 94102Not yet recruiting
United States, California, San Francisco 94102Terminated
United States, California, San Luis Obispo 93401Completed
United States, California, Sepuldeva 91343Completed
United States, California, Stockton 95207Completed
United States, California, Sunnyvale 94086Terminated
United States, California, Sylmar 91342-1495Completed
United States, California, Vista 92083Completed
United States, California, Vista 92083Terminated
United States, California, Walnut Creek 94598Completed
United States, Colorado, Arvada 80002Completed
United States, Colorado, Denver 80218Completed
United States, Colorado, Denver 80206Completed
United States, Colorado, Fort Collins 80528Completed
United States, Colorado, Longmont 80501Completed
United States, Colorado, Longmont 80501Terminated
United States, Colorado, Loveland 80538Completed
United States, Colorado, Pueblo 81001Completed
United States, Colorado, Wheat Ridge 80033Completed
United States, Connecticut, Hartford 06105Completed
United States, Connecticut, Stamford 06902Completed
United States, Florida, Altamonte Springs 32701Terminated
United States, Florida, Atlantis 33462Completed
United States, Florida, Bay Pines 33744Completed
United States, Florida, Brandon 33511Completed
United States, Florida, Clearwater 33756Completed
United States, Florida, Fort Lauderdale 33316Completed
United States, Florida, Jacksonville 32205Completed
United States, Florida, Jacksonville 32216Terminated
United States, Florida, Largo 33770Completed
United States, Florida, Longwood 32779Completed
United States, Florida, Loxahatchee 33470Terminated
United States, Florida, Miami 33136Completed
United States, Florida, Pace 32571Completed
United States, Florida, Palm Springs 33461Completed
United States, Florida, Pensacola 32514Terminated
United States, Florida, Sarasota 34239Completed
United States, Florida, Tamarac 33321Completed
United States, Florida, Tampa 33613Completed
United States, Florida, West Palm Beach 33409Completed
United States, Florida, West Palm Beach 33409Terminated
United States, Florida, Zephyrhills 33540Completed
United States, Georgia, Atlanta 30342Completed
United States, Georgia, Augusta 30901Completed
United States, Georgia, Blue Ridge 30513Completed
United States, Georgia, Decatur 30033Completed
United States, Georgia, Marietta 30066Completed
United States, Georgia, Rome 30165Completed
United States, Georgia, Roswell 30076Completed
United States, Idaho, Coeur D'Alene 83814Completed
United States, Illinois, Champaign 61821Completed
United States, Illinois, Chicago 60612-3824Completed
United States, Illinois, Chicago 60612-7323Completed
United States, Illinois, Hines 60141-5099Completed
United States, Illinois, North Chicago 60064Completed
United States, Illinois, Peoria 61602Completed
United States, Indiana, South Bend 46617Completed
United States, Iowa, Dubuque 52001Completed
United States, Kansas, Wichita 67207Completed
United States, Kansas, Wichita 67208Completed
United States, Kentucky, Lexington 40536Completed
United States, Kentucky, Louisville 40215Terminated
United States, Louisiana, Lafayette 70503Completed
United States, Louisiana, Shreveport 71103Completed
United States, Louisiana, Sunset 70584Completed
United States, Maine, Auburn 04210Completed
United States, Maryland, Baltimore 21224Completed
United States, Maryland, Baltimore 21204Completed
United States, Massachusetts, Boston 02135Completed
United States, Massachusetts, Swansea 02777Completed
United States, Michigan, Cadillac 49601Completed
United States, Michigan, Cadillac 49601Terminated
United States, Michigan, Livonia 48152Completed
United States, Michigan, St. Joseph 49085Completed
United States, Michigan, Traverse City 49684Completed
United States, Minnesota, Edina 55438Completed
United States, Minnesota, Minneapolis 55417Completed
United States, Mississippi, Jackson 39202Completed
United States, Missouri, Chesterfield 63017Completed
United States, Missouri, Jefferson City 65109Completed
United States, Missouri, Kansas City 64108Completed
United States, Missouri, St. Charles 63301Completed
United States, Missouri, St. Louis 63141Completed
United States, Missouri, St. Louis 63110Terminated
United States, Montana, Billings 59102Completed
United States, Nebraska, Omaha 68124Completed
United States, Nebraska, Omaha 68105Completed
United States, Nebraska, Omaha 68198-2456Completed
United States, Nebraska, Omaha 68198Completed
United States, Nebraska, Omaha 68134Completed
United States, Nebraska, Omaha 68134Terminated
United States, Nevada, Las Vegas 89104Completed
United States, New Hampshire, Gilford 3249Completed
United States, New Hampshire, Lebanon 03756Completed
United States, New Jersey, East Orange 07018Completed
United States, New Jersey, New Brunswick 8901Terminated
United States, New Jersey, Newark 07112Completed
United States, New Jersey, Summit 07091Completed
United States, New Jersey, Trenton 8629Completed
United States, New Mexico, Albuquerque 87108Completed
United States, New Mexico, Albuquerque 87108Terminated
United States, New York, Albany 12205Completed
United States, New York, Albany 12208Terminated
United States, New York, Bronxville 10708Completed
United States, New York, Brooklyn 11217Completed
United States, New York, Buffalo 14221Completed
United States, New York, Great Neck 11023Completed
United States, New York, Mineola 11501Terminated
United States, New York, New York 10011Completed
United States, New York, New York 10016Completed
United States, New York, New York 10029Terminated
United States, New York, New York 10025Terminated
United States, North Carolina, Chapel Hill 27514Terminated
United States, North Carolina, Charlotte 28207Completed
United States, North Carolina, Elizabeth City 27909Completed
United States, North Carolina, Greenville 27834Terminated
United States, North Carolina, High Point 27262Completed
United States, North Carolina, Wilmington 28401Completed
United States, North Carolina, Winston-Salem 27157Completed
United States, North Carolina, Winston-Salem 27103Terminated
United States, Ohio, Cincinnati 45219Completed
United States, Ohio, Cincinnati 45267-0405Completed
United States, Ohio, Cleveland 44024Completed
United States, Ohio, Franklin 45005Completed
United States, Ohio, Toledo 43614-5809Completed
United States, Ohio, Toledo 43617Completed
United States, Oklahoma, Oklahoma City 73104Completed
United States, Oregon, Lake Oswego 97035Completed
United States, Oregon, Medford 97504Completed
United States, Oregon, Portland 97213-2281Completed
United States, Oregon, Portland 97213Completed
United States, Pennsylvania, Allentown 18104Completed
United States, Pennsylvania, Downington 19335Completed
United States, Pennsylvania, Doylestown 8901Terminated
United States, Pennsylvania, Erie 16508Completed
United States, Pennsylvania, Philadelphia 19148Completed
United States, Pennsylvania, Philadelphia 19140Completed
United States, Pennsylvania, Philadelphia 19129Completed
United States, Pennsylvania, Pittsburgh 15218Completed
United States, Pennsylvania, Pittsburgh 15213Completed
United States, Pennsylvania, Ridley Park 19078Completed
United States, Rhode Island, Cranston 02920Completed
United States, Rhode Island, East Providence 02914Completed
United States, South Carolina, Charleston 29406-7108Completed
United States, South Carolina, Charleston 29403Completed
United States, South Carolina, Greer 29651Completed
United States, South Carolina, Simpsonville 29681Completed
United States, South Carolina, Spartanburg 29303Completed
United States, Tennessee, Bristol 37620Completed
United States, Tennessee, Johnson City 37601Completed
United States, Tennessee, Kingsport 37660Completed
United States, Tennessee, Milan 38372Completed
United States, Tennessee, Morristown 37813Completed
United States, Texas, Corsicana 75110Completed
United States, Texas, Houston 77074Completed
United States, Texas, Houston 77030Completed
United States, Texas, Houston 77024Completed
United States, Texas, San Antonio 78205Completed
United States, Texas, San Antonio 78217Completed
United States, Utah, Salt Lake City 84102Completed
United States, Virginia, Chesapeake 23320Completed
United States, Virginia, Fredericksburg 22401Completed
United States, Virginia, Richmond 23225Completed
United States, Virginia, Richmond 23249Completed
United States, Virginia, Richmond 23249Terminated
United States, Virginia, Roanoke 24016Completed
United States, Virginia, Virginia Beach 23454Completed
United States, Washington, Bellingham 98226Completed
United States, Washington, Spokane 99204Completed
United States, Washington, Spokane 99202Completed
United States, West Virginia, Charleston 25304Completed
United States, West Virginia, Huntington 25701-1693Terminated
United States, Wisconsin, La Crosse 54601Completed
United States, Wisconsin, Madison 53705Completed

Study Design

  • Primary Purpose: Treatment
  • Allocation: Randomized
  • Study Design: Parallel Assignment
  • Study Classification: Not Available
  • Masking: Not Available
  • Masked Subject: No
  • Masked Caregiver: No
  • Masked Investigator: No
  • Masked Assessor: No
Primary Outcomes:

  • All cause mortality at 3 years
    Timeframe:

Secondary Outcomes:

  • Rate of moderate and severe COPD exacerbations and health status assessed by the St. George's Respiratory Questionnaire.
    Timeframe:

Interventions:

  • Drug: Salmeterol 50mcg/ Fluticasone Propionate 500mcg

Keyword:

  • mortality, TORCH, SERETIDE, ADVAIR, COPD
Inclusion / Exclusion Criteria: Click to view inclusion/exclusion criteria:
Enrollment: 6228

Clinical Publications:

  • Briggs A, Glick H, Lozano-Ortega G, et al. Is treatment with ICS and LABA cost-effective for COPD? Multinational economic analysis of the TORCH study. Eur Respir J 2009 Aug 28. [Epub ahead of print].
  • Calverley PM, Anderson JA, Celli B, et al; TORCH investigators. Salmeterol and fluticasone propionate and survival in chronic obstructive pulmonary disease. N Engl J Med 2007;356(8):775–89.
  • Celli BR, Thomas NE, Anderson JA, et al. Effect of pharmacotherapy on rate of decline of lung function in chronic obstructive pulmonary disease: results from the TORCH study. Am J Respir Crit Care Med 2008;178(4):332–8.
  • Christine R Jenkins, Paul W Jones, Peter M A Calverley, Bartolome Celli, Julie A Anderson, Gary T Ferguson, Julie C Yates, Lisa R Willits, Jörgen Vestbo. Efficacy of salmeterol/fluticasone propionate by GOLD stage of chronic obstructive pulmonary disease: analysis from the randomised, placebo-controlled TORCH study . [Respir Res]. 2009;10(59):
  • Crim C, Calverley PM, Anderson JA, et al. Pneumonia risk in COPD patients receiving inhaled corticosteroids alone or in combination: TORCH study results. Eur Respir J 2009;34(3):641–7.
  • Ernst P, Suissa S. Pneumonia in elderly patients with chronic obstructive pulmonary disease. Curr Infect Dis Rep 2008;10(3):223–8.
  • Ferguson GT, Calverley PM, Anderson JA, et al. Prevalence and progression of osteoporosis in patients with COPD: results from the TOwards a Revolution in COPD Health study. Chest 2009;136(6):1456–65.
  • Ferguson GT, Calverley PMA, Anderson JA, Jenkins CR, Jones PW, Willits LR, Yates JC, Vestbo J, Celli B. Prevalence and progression of osteoporosis in patients with COPD: results from TORCH. Chest. 2009;136:1456-65
  • Hanania NA. The impact of inhaled corticosteroid and long-acting beta-agonist combination therapy on outcomes in COPD. Pulm Pharmacol Ther 2008;21(3):540–50.
  • Houghton CM, Lawson N, Borrill ZL, et al. Comparison of the effects of salmeterol/fluticasone propionate with fluticasone propionate on airway physiology in adults with mild persistent asthma. Respiratory Research 2007; 8: 52.
  • Jenkins CR, Jones PW, Calverley PM, et al. Efficacy of salmeterol/fluticasone propionate by GOLD stage of chronic obstructive pulmonary disease: analysis from the randomised, placebo-controlled TORCH study. Respir Res 2009;10:59. [Epub].
  • Johnson M, Agusti AG, Barnes NC. Reflections on TORCH: potential mechanisms for the survival benefit of salmeterol/fluticasone propionate in COPD patients. COPD 2008;5:369–75.
  • Keene ON, Vestbo J, Anderson JA, et al. Methods for therapeutic trials in COPD: lessons from the TORCH trial. Eur Respir J 2009;34(5):1018–23.
  • M Bradley Drummond, Robert A Wise, Matthias John, Michael Zvarich, Lorcan P McGarvey. Accuracy of death certificates in chronic obstructive pulmonary disease: Analysis from the TORCH trial. [COPD]. 2010;7:179-185.
  • Marchand E. Effect of pharmacotherapy on rate of decline of FEV(1) in the TORCH study. Am J Respir Crit Care Med 2009;179(5):426; author reply 426–7.
  • McGarvey LP, John M, Anderson JA, et al. Ascertainment of cause-specific mortality in COPD -- operations of the TORCH Clinical Endpoint Committee. Thorax 2007;62(5):411–5.
  • Middleton PG. Management of patients with COPD: a comparison of the INSPIRE and TORCH studies. Am J Respir Crit Care Med 2008;178(1):106; author reply 106–7.
  • Miravitlles M, Anzueto A. Insights into interventions in managing COPD patients: lessons from the TORCH and UPLIFT studies. Int J Chron Obstruct Pulmon Dis 2009;4:185–201
  • Niewoehner DE. TORCH and UPLIFT: what has been learned from the COPD "mega-trials"? COPD 2009;6(1):1–3.
  • Peter M.A. Calverley, Julie A. Anderson, Bartolome Celli, Gary T. Ferguson, Christine Jenkins, Paul W. Jones, Courtney Crim, Lisa R. Willits, Julie C. Yates, Jørgen Vestbo. Cardiovascular events in patients with chronic obstructive pulmonary disease: TORCH study results. [Thorax]. 2010;65:719-725.
  • Salmeterol plus fluticasone fails to reduce mortality in patients with COPD. Formulary 2007;42:245–6.
  • Stockley RA. Progression of chronic obstructive pulmonary disease: impact of inflammation, comorbidities and therapeutic intervention. Curr Med Res Opin 2009;25:1235–45.
  • Suissa S, Ernst P, Vandemheen KL, Aaron SD. Methodological issues in therapeutic trials of COPD. Eur Respir J 2008;31(5):927–33.
  • Vestbo J and the TORCH Study Group. The TORCH (Towards a Revolution in COPD Health) survival study protocol. Eur Respir J 2004;24:206-210
  • Vestbo J, Anderson JA, Calverley PM, et al. Adherence to inhaled therapy, mortality and hospital admission in COPD. Thorax 2009;64(11):939–43.
  • A. Briggs, H. Glick, G. Lozano-Ortega, M. Spencer, P. Calverley, P. Jones, J. Vestbo, and On behalf of the TORCH investigators . Is treatment with ICS and LABA cost-effective for COPD? Multinational economic analysis of the TORCH study. Eur Respir J. 2010;35:532-9.
  • Bartolome Celli, Jörgen Vestbo, Christine R. Jenkins, Paul W. Jones, Gary T. Ferguson, Peter M.A. Calverley, Julie C. Yates, Julie A. Anderson, Lisa R. Willits, Robert A. Wise; on behalf of the investigators of the TORCH study . Gender Differences in Mortality and Clinical Expressions of Patients with COPD: The TORCH Experience. Am J Respir Crit Care Med. 2010
  • C. Crim, P. M. A. Calverley, J. A. Anderson, B. Celli, G. T. Ferguson, C. Jenkins, P. W. Jones, L. R. Willits, J. C. Yates, and J. Vestbo . Pneumonia risk in COPD patients receiving inhaled corticosteroids alone or in combination: TORCH study results. Eur Respir J. 2009;34(3):641-647.
  • Calverley PM, Anderson JA, Celli B, Ferguson GT, Jenkins C, Jones PW, Yates JC, Vestbo J; TORCH investigators . Salmeterol and fluticasone propionate and survival in chronic obstructive pulmonary disease. N. Engl. J. Med. February 22nd 2007;356:775-789.
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