#map-container {
    width: 100%;
    height: 400px;
    display: block;
    position: relative !important; 
}

#gsk-sidebar-search-frm #edit-patient-level-sharing-filter label[for="edit-patient-level-sharing-filter-yes"] {
    font-size: 12px !important;
}
#gsk-top-search-form #edit-top-keyword {
    width: 100% !important;
}
#gsk-top-search-form .form-autocomplete{
    background-image: none !important;
}
@media (min-width:768px) {
    .custom-col-padd .gskstudy-grid-holder .gskstudy-grid {
        padding: 0 0.625rem
    }
}
@media (min-width:992px) {
    header .main-nav .main-nav-container .navbar-collapse .nav-pills {
        width:100%;
    }
    header .main-nav .main-nav-container .navbar-collapse .nav-pills .nav-item .nav-link {
        white-space: nowrap;
    }
    header .main-nav .main-nav-container .navbar-collapse .nav-pills .nav-item .nav-link.icon-home {
        max-width: 50%;	
    }  
}
.gsk-sdtdesign-holder .outcome-holder .outcome-box .fa-circle,
.interventions-holder .interventions-box .fa-circle {
    position: relative;
}
.gsk-sdtdesign-holder .outcome-holder .outcome-box .fa-circle:before,
.interventions-holder .interventions-box .fa-circle:before {
    font-size: 5px;
    position: absolute;
    margin-top: -8px;
}
.gsk-sdtdesign-holder .outcome-holder {
    padding-left: 0.75rem;
}
.gsk-sdtdesign-holder .outcome-holder .outcome-box{
    padding-left:0;
}
.gsk-sdtdesign-holder .outcome-holder .outcome-box h5 {
    margin-left:0;
}
.interventions-holder .interventions-box.paddingleft0 {
    padding-left: 5px;
}

.blue-form{
    min-height: 700px;
}
@media (min-width: 992px){
    .m-data-holder .col-left-panel {
        display: inline-block;
        float: left;
        width: 50%;
    }
    #advanced-search-form #edit-vaccines .checkbox-handler {
        margin: 0.3125rem 0 0;
    }
    #advanced-search-form #edit-patient-level-sharing .checkbox-handler {
        margin: 0.625rem 0 0;
    }    
}

.main-nav #navbar-menu li:nth-last-child(2),
.main-nav #navbar-menu li:nth-last-child(3),
.main-nav #navbar-menu li:nth-last-child(1){
    display:none;
}
@media (max-width:991px) {
    .main-nav #navbar-menu li:nth-last-child(2),
    .main-nav #navbar-menu li:nth-last-child(3),
    .main-nav #navbar-menu li:nth-last-child(1){
        display:block;
    }
}

.gskstudy-grid-holder-module .gsk-col {
    margin: 15px 0;
}
.gskstudy-grid-holder-module .gsk-col .col-tooltip a {
    text-decoration: underline;
}
@media screen and (min-width: 36em) {
    .gskstudy-grid-holder-module .gsk-col {
        float: left;
        border-right: 1px solid #ccc;
        margin: 0;
        padding: 0 10px;
        text-align: center;
    } }

.gskstudy-grid-holder-module .gsk-col:last-child {
    border-right: unset; }
.gskstudy-grid-holder-module .gsk-col:last-child .col-tooltip {
    max-width: 100%; }
.gskstudy-grid-holder-module .gsk-col:last-child .col-last {
    display: none; }
.gskstudy-grid-holder-module .gsk-col .col-tooltip {
    width: 46%;
    display: inline-block;
    max-width: 100%;
    vertical-align: top;
    margin: 0 10px 0 0; }
.gskstudy-grid-holder-module .gsk-col .without_ctr .col-tooltip {
    width: 100%;
    display: block;
    max-width: 100%;
    vertical-align: unset;
    margin: 0 10px 0 0; }
@media screen and (min-width: 36em) {
    .gskstudy-grid-holder-module .gsk-col .col-tooltip {
        width: auto;
        display: block;
        max-width: 100%;
        vertical-align: unset;
        margin: 0; } }
@media screen and (min-width: 36em) {
    .gskstudy-grid-holder-module .gsk-col .without_ctr .col-tooltip {
        width: 100%;
        display: block;
        max-width: 100%;
        vertical-align: unset;
        margin: 0; } }
@media screen and (min-width: 62em) {
    .gskstudy-grid-holder-module .gsk-col .col-tooltip {
        display: inline-block;
        /*max-width: 48%;*/
        text-align: center;
    } }
.gskstudy-grid-holder-module .gsk-col .col-first,
.gskstudy-grid-holder-module .gsk-col .col-mid {
    display: inline-block;
    max-width: 100%;
    width: 46%; }
@media screen and (min-width: 36em) {
    .gskstudy-grid-holder-module .gsk-col .col-first,
    .gskstudy-grid-holder-module .gsk-col .col-mid {
        display: block;
        margin: 0 auto;
        max-width: 100%;
        width: 100%; } }
@media screen and (min-width: 62em) {
    .gskstudy-grid-holder-module .gsk-col .col-first,
    .gskstudy-grid-holder-module .gsk-col .col-mid {
        max-width: 50%;
        display: inline-block;
        vertical-align: top;
        text-align: center;
    } }
.gskstudy-grid-holder-module .gsk-col .col-first .img-block,
.gskstudy-grid-holder-module .gsk-col .col-mid .img-block {
    width: 30%;
    background: #f36533;
    padding: 4px 6px 6px;
    display: inline-block;
    max-width: 100%;
    vertical-align: unset;
    text-align: center;
    margin-right: 5px;
}
.gskstudy-grid-holder-module .gsk-col .col-first .img-block img,
.gskstudy-grid-holder-module .gsk-col .col-mid .img-block img {
    max-width: 50%;
    margin: 0 auto;
    text-align: center;
}
.gskstudy-grid-holder-module .gsk-col .col-first span,
.gskstudy-grid-holder-module .gsk-col .col-mid span {
    width: calc(100% - 80px);
    margin-left:5px;
    display: inline-block;
    line-height: 1.1;
    font-weight: 500;
    font-size: 12px;
    vertical-align: middle;
}
@media screen and (min-width: 36em) {
    .gskstudy-grid-holder-module .gsk-col .col-first span,
    .gskstudy-grid-holder-module .gsk-col .col-mid span {
        display: inline-block;
        width: 64%;
        line-height: 1.1;
        margin-left: 0;
        font-size: 12px;
        font-weight: 500;
        vertical-align: middle;
    } }
.col-tooltip strong i {
    color: #f36533;
    margin: 0 4px;
}
@media screen and (max-width: 575px) {
    .gskstudy-grid-holder-module .gsk-col .col-first span, 
    .gskstudy-grid-holder-module .gsk-col .col-mid span {
        /* width: calc(100% - 38px); */
    }
    .gskstudy-grid-holder-module .gsk-col .col-first .img-block, 
    .gskstudy-grid-holder-module .gsk-col .col-mid .img-block {
        padding: 2px 3px 4px;
    }
}
@media (min-width:768px){
    .custom-preclinical{float:right;}
}

@media screen and (max-width: 767px){
    .custom-preclinical{
        margin: 0 auto 1.25rem;
        text-align:center;
    }
}
.custom-preclinical:hover img,
.region-antibiotic-right-section:hover img {
    -webkit-transform: scale(1.1);
    -ms-transform: scale(1.1);
    transform: scale(1.1);
}
.custom-preclinical img,
.region-antibiotic-right-section img  {
    -webkit-backface-visibility: hidden;
    backface-visibility: hidden;
    -webkit-transition: -webkit-transform .5s ease-in-out;
    transition: transform .5s ease-in-out;
    -webkit-transform: scale(1);
    -ms-transform: scale(1);
    transform: scale(1);
}
.region-antibiotic-right-section .content{
    position: relative;
    z-index:1;
    margin: 20px;
}

.custom-preclinical {
    margin: 0 20px 20px;
}
.region-antibiotic-right-section .content p {
    margin:0;
}
@media (min-width:567px) {
    .region-antibiotic-right-section .content{
        margin:0 20px 0 20px;
    }
}
.search-list-box table tr th,
.filter-select-holder label,
.filter-accordion .gsk-menu-title,
.filter-select-holder #edit-patient-level-sharing-filter label{
    font-weight:400;
}


.search-list-box .description-holder .truncate-wrapper .truncate-row .truncate-cell .truncate-content .truncate-ellipsis,
.search-list-box .description-holder .truncate-wrapper{
    font-weight: 700;
    color: #15717d;
}

.age-bar-icon{
    font-size: 1.2rem;
}

.search-list-box table tr td p{
    font-size:12px;
}
.selectric{
    border: 1px solid #ced4da;
}
.gsk-sdtdesign-holder .gsk-stddesign-list ul li span {
    display: inline-block;
    vertical-align: top;
    text-transform: capitalize;
    max-width: 18.6rem;
}
.custom-preclinical {
    position: relative;
    overflow: hidden; 
}
.gskstudy-grid-holder .gskstudy-grid p {
    margin: 0;
    font-size: 1.125rem;
    word-wrap: break-word;
    text-transform: capitalize;
}

.banner-holder {
    position: relative;
    padding-right: 15px;
    padding-left: 15px;
} 

@media (min-width: 768px){
    .custom-col-padd .gskstudy-grid-holder .gskstudy-grid {
        padding: 0 0.625rem; 
    }
}

.gskstudy-grid-holder .col-sm-4{
    padding:0;
    margin:0;
}
@media screen and (min-width: 768px) {
    .study-doc-module {
        padding: 0 30px 0 0;
        float: left;
    }
}
/* pre-clinical top secttion START */
    .pre-clinical-module .img-block-module {
        position: relative;
    }
    .pre-clinical-module .img-block-module img {
      width: 100%;
    }
    .pre-clinical-module .img-block-module .caption-data {
      position: relative;
      background-color: rgba(255, 255, 255, 0.902);
    }
    @media screen and (min-width: 991px) {
      .pre-clinical-module .img-block-module .caption-data {
        position: absolute;
        top: 23%;
        bottom: 25%;
        left: 0;
        right: auto;
        max-width: 52%;
      }
    }
    .pre-clinical-module .img-block-module .caption-data .border-left-section {
      border-left: 4px solid #f47447;
      margin: 2rem 0 0;
    }
    @media screen and (min-width: 991px) {
      .pre-clinical-module .img-block-module .caption-data .border-left-section {
        margin: 2rem 0;
      }
    }
    @media screen and (min-width: 991px) {
      .pre-clinical-module .img-block-module .caption-data .border-left-section {
        margin: 2.1875rem 0 2.1875rem 1.875rem;
      }
    }
    .pre-clinical-module .img-block-module .caption-data .border-left-section h2 {
      font-size: 1.375rem;
      color: #72635d;
      font-weight: bold;
      padding: 0 0 0.9375rem 1.25rem;
      margin: 0;
    }
    @media screen and (min-width: 768px) {
      .pre-clinical-module .img-block-module .caption-data .border-left-section h2 {
        font-size: 2rem;
      }
    }
    .pre-clinical-module .img-block-module .caption-data .border-left-section p {
      font-size: 1.2rem;
      font-weight: normal;
      color: #72635d;
      margin: 0;
      width: 100%;
      display: block;
      padding: 0 0 0 1.25rem;
    }
    @media screen and (min-width: 991px) {
      .pre-clinical-module .img-block-module .caption-data .border-left-section p {
        max-width: 75%;
        width: 100%;
      }
    }
    
    .preclinical-publications-form {
        display: -ms-flexbox;
        display: flex;
        -ms-flex-wrap: wrap;
        flex-wrap: wrap;
        padding: 1.875rem 2.5rem 1.875rem 2.5rem;
    }
    .dataTables_filter .preclinical-publications-form > .key-search {
        position: relative;
        width: 100%;
        min-height: 1px;
        padding-left: 0;
        -ms-flex: 0 0 100%;
        flex: 0 0 100%;
        max-width: 100%;
        padding-right: 0; 
    }
    @media screen and (min-width: 62em) {
        .dataTables_filter .preclinical-publications-form > .key-search {
            position: relative;
            width: 100%;
            min-height: 1px;
            padding-left: 0;
            -ms-flex: 0 0 58.333333%;
            flex: 0 0 58.333333%;
            max-width: 58.333333%;
            padding-right: 0.9375rem; 
        }
    }
    .dataTables_filter .preclinical-publications-form > .key-search > span {
        display: block;
        font-weight: 700;
        color: #544f40;
        margin-bottom: 0.1875rem; 
    }
    .dataTables_filter .preclinical-publications-form > .key-search > label {
        width: 100%; 
    }
    .dataTables_filter .preclinical-publications-form > .pub-year {
        position: relative;
        width: 100%;
        min-height: 1px;
        padding-right: 0;
        -ms-flex: 0 0 100%;
        flex: 0 0 100%;
        max-width: 100%;
        padding-left: 0; 
    }
    @media screen and (min-width: 62em) {
        .dataTables_filter .preclinical-publications-form > .pub-year {
            position: relative;
            width: 100%;
            min-height: 1px;
            padding-right: 0;
            -ms-flex: 0 0 41.666667%;
            flex: 0 0 41.666667%;
            max-width: 41.666667%;
            padding-left: 0.9375rem; 
        } 
    }
    .dataTables_filter .preclinical-publications-form > .pub-year > span {
        display: block;
        font-weight: 700;
        color: #544f40;
        margin-bottom: 0.1875rem; 
    }
    .dataTables_filter {
        margin: 1.875rem 0;
        background-color: rgb(255, 255, 255);
        box-shadow: 0px 10px 30px 0px rgba(0, 0, 0, 0.15);
    }
    .preclinical-publications-form .mb-1 {
        margin-bottom: 1.25rem !important;
    }
    .preclinical-publications-form .mb-1 .color-blue.fs-18 {
        color: #f36533;
    }
/* pre-clinical top section END */
/* home owl carousel START */
.custom-banner-holder.banner-holder {
    padding: 0;
}
.custom-banner-holder.banner-holder .slide-content {
    background-image: none;
    padding: 4% 8% 1.25rem 0;
    max-width: 96%;
    width: 100%;
}
@media screen and (min-width:768px) {
    .custom-banner-holder.banner-holder .slide-content {
        padding: 0 8% 1.25rem 0;
        max-width: 96%;
        width: 100%;
        margin: 40px auto;
    }
}
@media screen and (min-width:992px) {
    .custom-banner-holder.banner-holder .slide-content {
        padding: 0 8% 1.25rem 0;
        max-width: 60%;
        width:100%;
        margin: -15px auto;
    }
}
@media screen and (min-width:1100px) {
    .custom-banner-holder.banner-holder .slide-content {
        padding: 2% 8% 1.25rem 0;
        max-width: 60%;
        width:100%;
    }
}
.custom-banner-holder.banner-holder .slide-content .overlay-data-caption {
    background-color: rgba(255, 255, 255, 0.902);
    padding: 1.125rem;
}
.custom-banner-holder.banner-holder .slide-content .overlay-data-caption .border-left-module {
    border-left: 4px solid #f47447;
    margin: 10px 10px 15px 15px;
}
.custom-banner-holder.banner-holder .slide-content .overlay-data-caption .border-left-module h1,
.custom-banner-holder.banner-holder .slide-content .overlay-data-caption .border-left-module h2{
    color: #72635d;
    font-weight: bold;
    padding: 0 0 0.9375rem 1.25rem;
    margin: 0;
    line-height: 1.1;
}
.custom-banner-holder.banner-holder .slide-content .overlay-data-caption .border-left-module p {
    font-size: 1.2rem;;
    font-weight: normal;
    color: #72635d;
    margin: 0;
    width: 100%;
    display: block;
    padding: 0 0 0 1.25rem;
    line-height: 1.2;
}
/* home owl caroudel END*/
@media screen and (max-width: 767px){
   
    
.banner-holder .slide-content {
    padding: 5% 5% 1.25rem 2%;
    height: auto;
}

.custom-banner-holder.banner-holder .slide-content .overlay-data-caption .border-left-module p {
    font-size: 0.9rem;
    font-weight: normal;
    color: #72635d;
    margin: 0;
    width: 100%;
    display: block;
    padding: 0 0 0 1.25rem;
    line-height: 1.2;
}

.custom-banner-holder.banner-holder .slide-content .overlay-data-caption .border-left-module h1, .custom-banner-holder.banner-holder .slide-content .overlay-data-caption .border-left-module h2 {
    color: #72635d;
    font-weight: bold;
    padding: 0 0 0.9375rem 1.25rem;
    margin: 0;
    line-height: 1.1;
    font-size: 1.175rem;
}

.custom-banner-holder.banner-holder .slide-content .overlay-data-caption {
    background-color: rgba(255, 255, 255, 0.902);
    padding: 0;
}

.custom-banner-holder.banner-holder .slide-content .overlay-data-caption .border-left-module {
    border-left: 4px solid #f47447;
    margin: 10px 10px 0px 10px;
}

.clinical-study-section {
    margin:0;
}

}

@media screen and (min-width:768px) and (max-width:991px) {
    .custom-banner-holder.banner-holder .slide-content {
       
        max-width: 65%;
       
    }
    
.custom-banner-holder.banner-holder .slide-content .overlay-data-caption .border-left-module {
    border-left: 4px solid #f47447;
    margin: 10px 10px 0px 10px;
}
    .banner-holder .slide-content {
    padding: 5% 5% 1.25rem 2%;
    height: auto;
}

.custom-banner-holder.banner-holder .slide-content .overlay-data-caption .border-left-module p {
    font-size: 0.9rem;
    font-weight: normal;
    color: #72635d;
    margin: 0;
    width: 100%;
    display: block;
    padding: 0 0 0 1.25rem;
    line-height: 1.2;
}

.custom-banner-holder.banner-holder .slide-content .overlay-data-caption .border-left-module h1, .custom-banner-holder.banner-holder .slide-content .overlay-data-caption .border-left-module h2 {
    color: #72635d;
    font-weight: bold;
    padding: 0 0 0.9375rem 1.25rem;
    margin: 0;
    line-height: 1.1;
    font-size: 1.175rem;
}
}

.owl-carousel .owl-nav button span
{
    color: #f47447;
    font-size: 34px;
    margin-top: -8px;
}
@media screen and (max-width: 767px){
.owl-carousel .owl-nav button span{
    color: #f47447;
    font-size: 34px;
    margin-top: -14px;
}
.home-banner .owl-nav button[class*='owl-'] {
    background-color: #FFF;
    position: fixed;
    top: 24%;
    left: 0;
    margin-top: -1.25rem;
    width: 1.75rem;
    height: 1.75rem;
    text-align: center;
    padding-right: 0.25rem !important;
    border-radius: 50%;
} 
}

@media screen and (max-width: 48em){
table.dataTable thead th.sorting_asc:after {
    margin-top: 1.575rem;
}
}

.download-pdf.pdf-gray {
    background-color: #f5f5f5;
    font-size: 0.925rem;
}

.download-pdf {
    padding: 0.5625rem 2.813rem 0.5625rem 0.625rem;
}