| Publication Year | Citation |
|---|---|
| 2016 | Batt SM, Cacho Izquierdo M, Castro Pichel J, et al. Whole Cell Target Engagement Identifies Novel Inhibitors of Mycobacterium tuberculosis Decaprenylphosphoryl-beta-d-ribose Oxidase. ACS Infect Dis. 2015;1(12):615-626. |
| 2016 | Amata E, Xi H, Colmenarejo G, et al. Identification of "Preferred" Human Kinase Inhibitors for Sleeping Sickness Lead Discovery. Are Some Kinases Better than Others for Inhibitor Repurposing? ACS Infect Dis. 2016;2(3):180-186. |
| 2016 | Haftchenary S, Nelson SD, Jr., Furst L, et al. Efficient Routes to a Diverse Array of Amino Alcohol-Derived Chiral Fragments. ACS Comb Sci. 2016;18(9):569-574. |
| 2016 | Ding Y, Franklin GJ, DeLorey JL, et al. Design and Synthesis of Biaryl DNA-Encoded Libraries. ACS Comb Sci. 2016;18(10):625-629. |
| 2016 | Rutkowska A, Thomson DW, Vappiani J, et al. A Modular Probe Strategy for Drug Localization, Target Identification and Target Occupancy Measurement on Single Cell Level. ACS Chem Biol. 2016;11(9):2541-2550. |
| 2016 | Joberty G, Boesche M, Brown JA, et al. Interrogating the Druggability of the 2-Oxoglutarate-Dependent Dioxygenase Target Class by Chemical Proteomics. ACS Chem Biol. 2016;11(7):2002-2010. |
| 2016 | Billin AN, Bantscheff M, Drewes G, et al. Discovery of Novel Small Molecules that Activate Satellite Cell Proliferation and Enhance Repair of Damaged Muscle. ACS Chem Biol. 2016;11(2):518-529. |
| 2016 | MacNair AJ, Millet CRP, Nichol GS, Ironmonger A, Thomas SP. Markovnikov-Selective, Activator-Free Iron-Catalyzed Vinylarene Hydroboration. ACS Catalysis. 2016;6(10):7217-7221. |
| 2016 | Mayer AP, Hottenstein CS. Ligand-Binding Assay Development: What Do You Want to Measure Versus What You Are Measuring? AAPS J. 2016;18(2):287-289. |
| 2016 | Rovati L, Cattini S, Crespi F. Near-infrared spectroscopy for non-invasive monitoring of drugs blood-brain barrier penetration. IEEE Instrumentation and Measurement Technology Conference 2016: 7520564 |
| 2016 | Miller RA, Melius J, Nunes N, Willighagen EL, Woollard P, Evelo CT. Finding drugs with common downstream effects, using direction information in biological pathways. CEUR Workshop Proceedings 2016: 1795 |
| 2016 | Korolj A, Zhang BY, Laschinger C, et al. Biomimetic 3D platform induces nephrin upregulation in differentiating podocytes in vitro. 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016: 389-390. Dublin, Ireland. |
| 2016 | Kumar A, Guardia A, Colmenarejo G, et al. A Focused Screen Identifies Antifolates with Activity on Mycobacterium tuberculosis. ACS Infect Dis. 2015;1(12):604-614. |
| 2016 | Deng H, Zhou J, Sundersingh F, et al. Discovery and Optimization of Potent, Selective, and in Vivo Efficacious 2-Aryl Benzimidazole BCATm Inhibitors. ACS Med Chem Lett. 2016;7(4):379-384. |
| 2016 | Handlon AL, Schaller LT, Leesnitzer LM, et al. Optimizing Ligand Efficiency of Selective Androgen Receptor Modulators (SARMs). ACS Med Chem Lett. 2016;7(1):83-88. |
| 2016 | Lin H, Zeng J, Xie R, et al. Discovery of a Novel 2,6-Disubstituted Glucosamine Series of Potent and Selective Hexokinase 2 Inhibitors. ACS Med Chem Lett. 2016;7(3):217-222. |
| 2016 | Pero JE, Rossi MA, Kelly MJ, 3rd, et al. Optimization of Novel Aza-benzimidazolone mGluR2 PAMs with Respect to LLE and PK Properties and Mitigation of CYP TDI. ACS Med Chem Lett. 2016;7(3):312-317. |
| 2016 | Xu H, Lu H, Xu Z, et al. Discovery of CNS Penetrant CXCR2 Antagonists for the Potential Treatment of CNS Demyelinating Disorders. ACS Med Chem Lett. 2016;7(4):397-402. |
| 2016 | Longo LS, Smith EF, Licence P. Study of the Stability of 1-Alkyl-3-methylimidazolium Hexafluoroantimonate(V) Based Ionic Liquids Using X-ray Photoelectron Spectroscopy. ACS Sustainable Chemistry & Engineering. 2016;4(11):5953-5962. |
| 2016 | Pérez B, Bulsara P, Rawlings AV, et al. Ultralong Fatty Acyl Derivatives As Occlusive Structure Lipids for Cosmetic Applications: Synthesis and Characterization. ACS Sustainable Chemistry & Engineering. 2016;4(12):7137-7146. |
| 2016 | Xie F, Ding X, Zhang QY. An update on the role of intestinal cytochrome P450 enzymes in drug disposition. Acta Pharm Sin B. 2016;6(5):374-383. |
| 2016 | Yu HB, Zou BY, Wang XL, Li M. Investigation of miscellaneous hERG inhibition in large diverse compound collection using automated patch-clamp assay. Acta Pharmacol Sin. 2016;37(1):111-123. |
| 2016 | Kost TA, Kemp CW. Fundamentals of Baculovirus Expression and Applications. Adv Exp Med Biol. 2016;896:187-197. |
| 2016 | Pennell MN, Kyle MP, Gibson SM, et al. Intercepting the Gold-Catalysed Meyer-Schuster Rearrangement by Controlled Protodemetallation: A Regioselective Hydration of Propargylic Alcohols. Advanced Synthesis & Catalysis. 2016;358(9):1519-1525. |
| 2016 | Shankaran M, Shearer TW, Stimpson SA, et al. Proteome-wide muscle protein fractional synthesis rates predict muscle mass gain in response to a selective androgen receptor modulator in rats. Am J Physiol Endocrinol Metab. 2016;310(6):E405-417. |
| 2016 | Caballero I, Lafuente MJ, Gamo FJ, Cid C. A high-throughput fluorescence-based assay for Plasmodium dihydroorotate dehydrogenase inhibitor screening. Anal Biochem. 2016;506:13-21. |
| 2016 | Bao J, Krylova SM, Cherney LT, et al. Predicting Electrophoretic Mobility of Protein-Ligand Complexes for Ligands from DNA-Encoded Libraries of Small Molecules. Anal Chem. 2016;88(10):5498-5506. |
| 2016 | Reading E, Munoz-Muriedas J, Roberts AD, Dear GJ, Robinson CV, Beaumont C. Elucidation of Drug Metabolite Structural Isomers Using Molecular Modeling Coupled with Ion Mobility Mass Spectrometry. Anal Chem. 2016;88(4):2273-2280. |
| 2016 | Patel E, Cicatiello P, Deininger L, et al. A proteomic approach for the rapid, multi-informative and reliable identification of blood. Analyst. 2016;141(1):191-198. |
| 2016 | Junnotula V, Licea-Perez H. LC-MS/MS quantification of dimethyl fumarate and methyl hydrogen fumarate in rat blood using tiopronin as trapping reagent. Analytical Methods. 2016;8(34):6420-6427. |
| 2016 | Licea-Perez H, Junnotula V, Zohrabian S, Karlinsey M. Development of a multi-sugar LC-MS/MS assay using simple chemical derivatization with acetic anhydride. Analytical Methods. 2016;8(15):3023-3033. |
| 2016 | Bamborough P, Chung CW, Demont EH, et al. A Chemical Probe for the ATAD2 Bromodomain. Angew Chem Int Ed Engl. 2016;55(38):11382-11386. |
| 2016 | Barham JP, Coulthard G, Kane RG, Delgado N, John MP, Murphy JA. Double Deprotonation of Pyridinols Generates Potent Organic Electron-Donor Initiators for Haloarene-Arene Coupling. Angew Chem Int Ed Engl. 2016;55(14):4492-4496. |
| 2016 | Cuetos A, Garcia-Ramos M, Fischereder EM, et al. Catalytic Promiscuity of Transaminases: Preparation of Enantioenriched beta-Fluoroamines by Formal Tandem Hydrodefluorination/Deamination. Angew Chem Int Ed Engl. 2016;55(9):3144-3147. |
| 2016 | Moragas T, Liffey RM, Regentova D, et al. Sigmatropic Rearrangement of Vinyl Aziridines: Expedient Synthesis of Cyclic Sulfoximines from Chiral Sulfinimines. Angew Chem Int Ed Engl. 2016;55(34):10047-10051. |
| 2016 | Rahemtulla BF, Clark HF, Smith MD. Catalytic Enantioselective Synthesis of C1 - and C2 -Symmetric Spirobiindanones through Counterion-Directed Enolate C-Acylation. Angew Chem Int Ed Engl. 2016;55(42):13180-13183. |
| 2016 | de Cozar C, Caballero I, Colmenarejo G, et al. Development of a Novel High-Density [3H]Hypoxanthine Scintillation Proximity Assay To Assess Plasmodium falciparum Growth. Antimicrob Agents Chemother. 2016;60(10):5949-5956. |
| 2016 | Penna-Coutinho J, Almela MJ, Miguel-Blanco C, et al. Transmission-Blocking Potential of MEFAS, a Hybrid Compound Derived from Artesunate and Mefloquine. Antimicrob Agents Chemother. 2016;60(5):3145-3147. |
| 2016 | Kellie JF, Kehler JR, Szapacs ME. Application of high-resolution MS for development of peptide and large-molecule drug candidates. Bioanalysis. 2016;8(3):169-177 |
| 2016 | Lu X. Development of an Excel-based laboratory information management system for improving workflow efficiencies in early ADME screening. Bioanalysis. 2016;8(2):99-110. |
| 2016 | Szapacs M, Mencken T, Williams J, Li Y. Utilizing enzymatic digestion procedures in the bioanalytical laboratory. Bioanalysis. 2016;8(1):29-36 |
| 2016 | Timmerman P, Blech S, White S, et al. Best practices for metabolite quantification in drug development: updated recommendation from the European Bioanalysis Forum. Bioanalysis. 2016;8(12):1297-1305. |
| 2016 | Karpus ON, Hsiao CC, de Kort H, Tak PP, Hamann J. Intracellular delivery of poly(I:C) induces apoptosis of fibroblast-like synoviocytes via an unknown dsRNA sensor. Biochem Biophys Res Commun. 2016;477(3):343-349. |
| 2016 | Ito G, Katsemonova K, Tonelli F, et al. Phos-tag analysis of Rab10 phosphorylation by LRRK2: a powerful assay for assessing kinase function and inhibitors. Biochem J. 2016;473(17):2671-2685. |
| 2016 | Okeke E, Parker T, Dingsdale H, et al. Epithelial-mesenchymal transition, IP3 receptors and ER-PM junctions: translocation of Ca2+ signalling complexes and regulation of migration. Biochem J. 2016;473(6):757-767. |
| 2016 | Hall ER, Bibby LI, Slack RJ. Characterisation of a novel, high affinity and selective alphavbeta6 integrin RGD-mimetic radioligand. Biochem Pharmacol. 2016;117:88-96. |
| 2016 | Stott LA, Hall DA, Holliday ND. Unravelling intrinsic efficacy and ligand bias at G protein coupled receptors: A practical guide to assessing functional data. Biochem Pharmacol. 2016;101:1-12. |
| 2016 | Sanchez-Murcia PA, Bueren-Calabuig JA, Camacho-Artacho M, Cortes-Cabrera A, Gago F. Stepwise Simulation of 3,5-Dihydro-5-methylidene-4H-imidazol-4-one (MIO) Biogenesis in Histidine Ammonia-lyase. Biochemistry. 2016;55(41):5854-5864. |
| 2016 | Ding Y, DeLorey JL, Clark MA. Novel Catalyst System for Suzuki-Miyaura Coupling of Challenging DNA-Linked Aryl Chlorides. Bioconjug Chem. 2016;27(11):2597-2600. |
| 2016 | Pavlovic D, Mutak S. Synthesis and antibacterial evaluation of novel 4''-glycyl linked quinolyl-azithromycins with potent activity against macrolide-resistant pathogens. Bioorg Med Chem. 2016;24(6):1255-1267. |
| 2016 | Bueno JM, Carda M, Crespo B, et al. Design, synthesis and antimalarial evaluation of novel thiazole derivatives. Bioorg Med Chem Lett. 2016;26(16):3938-3944. |
| 2016 | Garton NS, Barker MD, Davis RP, et al. Optimisation of a novel series of potent and orally bioavailable azanaphthyridine SYK inhibitors. Bioorg Med Chem Lett. 2016;26(19):4606-4612. |
| 2016 | Lawhorn BG, Philp J, Graves AP, et al. GSK114: A selective inhibitor for elucidating the biological role of TNNI3K. Bioorg Med Chem Lett. 2016;26(14):3355-3358. |
| 2016 | Mougenot P, Namane C, Fett E, et al. Synthesis and multiparametric evaluation of thiadiazoles and oxadiazoles as diacylglycerol acyltransferase type 1 inhibitors. Bioorg Med Chem Lett. 2016;26(1):25-32. |
| 2016 | Procopiou PA, Ancliff RA, Gore PM, et al. The discovery of quinoline based single-ligand human H1 and H3 receptor antagonists. Bioorg Med Chem Lett. 2016;26(24):5855-5859. |
| 2016 | Sparks SM, Zhou H, Generaux C, et al. Identification of nonabsorbable inhibitors of the scavenger receptor-BI (SR-BI) for tissue-specific administration. Bioorg Med Chem Lett. 2016;26(8):1901-1904. |
| 2016 | Hartkamp R, Moore TC, Iacovella CR, et al. Investigating the Structure of Multicomponent Gel-Phase Lipid Bilayers. Biophys J. 2016;111(4):813-823. |
| 2016 | Archibald PR, Chandra A, Thomas D, et al. Comparability of automated human induced pluripotent stem cell culture: a pilot study. Bioprocess Biosyst Eng. 2016;39(12):1847-1858. |
| 2016 | Fu Z, Baker D, Cheng A, Leighton J, Appelbaum E, Aon J. Characterization of a Saccharomyces cerevisiae fermentation process for production of a therapeutic recombinant protein using a multivariate Bayesian approach. Biotechnol Prog. 2016;32(3):799-812. |
| 2016 | St Amand MM, Hayes J, Radhakrishnan D, et al. Identifying a robust design space for glycosylation during monoclonal antibody production. Biotechnol Prog. 2016;32(5):1149-1162. |
| 2016 | Preyat N, Rossi M, Kers J, et al. Intracellular nicotinamide adenine dinucleotide promotes TNF-induced necroptosis in a sirtuin-dependent manner. Cell Death Differ. 2016;23(1):29-40. |
| 2016 | Dowling JP, Cai Y, Bertin J, Gough PJ, Zhang J. Kinase-independent function of RIP1, critical for mature T-cell survival and proliferation. Cell Death Dis. 2016;7(9):e2379. |
| 2016 | Klei LR, Hu D, Panek R, et al. MALT1 Protease Activation Triggers Acute Disruption of Endothelial Barrier Integrity via CYLD Cleavage. Cell Rep. 2016;17(1):221-232. |
| 2016 | Liang AC, Mandeville ET, Maki T, et al. Effects of Aging on Neural Stem/Progenitor Cells and Oligodendrocyte Precursor Cells After Focal Cerebral Ischemia in Spontaneously Hypertensive Rats. Cell Transplant. 2016;25(4):705-714. |
| 2016 | Cafferty BJ, Musetti C, Kim K, Horowitz ED, Krishnamurthy R, Hud NV. Small molecule-mediated duplex formation of nucleic acids with 'incompatible' backbones. Chem Commun (Camb). 2016;52(31):5436-5439. |
| 2016 | Colomer I, Empson CJ, Craven P, et al. A divergent synthetic approach to diverse molecular scaffolds: assessment of lead-likeness using LLAMA, an open-access computational tool. Chem Commun (Camb). 2016;52(45):7209-7212. |
| 2016 | Fernandez J, Chicharro J, Bueno JM, Lorenzo M. Isoxazole mediated synthesis of 4-(1H)pyridones: improved preparation of antimalarial candidate GSK932121. Chem Commun (Camb). 2016;52(66):10190-10192. |
| 2016 | Lanigan RM, Karaluka V, Sabatini MT, et al. Direct amidation of unprotected amino acids using B(OCH2CF3)3. Chem Commun (Camb). 2016;52(57):8846-8849. |
| 2016 | Orr D, Percy JM, Harrison ZA. A computational triage approach to the synthesis of novel difluorocyclopentenes and fluorinated cycloheptadienes using thermal rearrangements. Chem Sci. 2016;7(10):6369-6380. |
| 2016 | Murray AT, King R, Donnelly JVG, et al. Symbiotic Transition-Metal and Organocatalysis for Catalytic Ambient Amine Oxidation and Alkene Reduction Reactions. ChemCatChem. 2016;8(3):510-514. |
| 2016 | Fenner S, Wilson ZE, Ley SV. The Total Synthesis of the Bioactive Natural Product Plantazolicin A and Its Biosynthetic Precursor Plantazolicin B. Chemistry. 2016;22(44):15902-15912. |
| 2016 | Kerr WJ, Mudd RJ, Brown JA. Iridium(I) N-Heterocyclic Carbene (NHC)/Phosphine Catalysts for Mild and Chemoselective Hydrogenation Processes. Chemistry. 2016;22(14):4738-4742. |
| 2016 | Percy JM, Emerson H, Fyfe JW, et al. Modular Construction of Fluoroarenes from a New Difluorinated Building Block by Cross-Coupling/Electrocyclisation/Dehydrofluorination Reactions. Chemistry. 2016;22(34):12166-12175. |
| 2016 | Teci M, Tilley M, McGuire MA, Organ MG. Using Anilines as Masked Cross-Coupling Partners: Design of a Telescoped Three-Step Flow Diazotization, Iododediazotization, Cross-Coupling Process. Chemistry. 2016;22(48):17407-17415. |
| 2016 | Green D. In Silico Drug Discovery and Design . Edited by Claudio N. Cavasotto. ChemMedChem. 2016;11(6):638-638. |
| 2016 | Guardia A, Gulten G, Fernandez R, et al. N-Benzyl-4-((heteroaryl)methyl)benzamides: A New Class of Direct NADH-Dependent 2-trans Enoyl-Acyl Carrier Protein Reductase (InhA) Inhibitors with Antitubercular Activity. ChemMedChem. 2016;11(7):687-701. |
| 2016 | Rigo R, Bianco S, Musetti C, Palumbo M, Sissi C. Molecular Basis for Differential Recognition of G-Quadruplex versus Double-Helix DNA by Bis-Phenanthroline Metal Complexes. ChemMedChem. 2016;11(16):1762-1769. |
| 2016 | Theodoulou NH, Tomkinson NC, Prinjha RK, Humphreys PG. Progress in the Development of non-BET Bromodomain Chemical Probes. ChemMedChem. 2016;11(5):477-487. |
| 2016 | Jia W, Zhao L, Wei H, Zhu L, Fu L, Chen W. Iron-Catalyzed Cross-Coupling of Secondary Alkyl Chloride and the Alkynes Grignard Reagent. Chinese Journal of Organic Chemistry. 2016;36(5). |
| 2016 | Vicini P, Fields O, Lai E, et al. Precision medicine in the age of big data: The present and future role of large-scale unbiased sequencing in drug discovery and development. Clin Pharmacol Ther. 2016;99(2):198-207. |
| 2016 | Lopez-Sagaseta J, Malito E, Rappuoli R, Bottomley MJ. Self-assembling protein nanoparticles in the design of vaccines. Comput Struct Biotechnol J. 2016;14:58-68. |
| 2016 | Dumarey M, Talwar S, Yahyah M, Peterson J. Empirical Modelling to support Scale up of Primary Pharmaceutical Processes. In: Kravanja Z, Bogataj M, eds. Computer Aided Chemical Engineering. Vol 38: Elsevier B.V.; 2016:2241-2246. |
| 2016 | Workgroup EM, Marshall SF, Burghaus R, et al. Good Practices in Model-Informed Drug Discovery and Development: Practice, Application, and Documentation. CPT Pharmacometrics Syst Pharmacol. 2016;5(3):93-122. |
| 2016 | Desai KG. Chitosan Nanoparticles Prepared by Ionotropic Gelation: An Overview of Recent Advances. Crit Rev Ther Drug Carrier Syst. 2016;33(2):107-158. |
| 2016 | Yang Y, Zhang C, Pal K, et al. Application of Ultra-Performance Liquid Chromatography as an Online Process Analytical Technology Tool in Pharmaceutical Crystallization. Crystal Growth & Design. 2016;16(12):7074-7082. |
| 2016 | Goodfellow JA, Willison HJ. Antiganglioside, antiganglioside-complex, and antiglycolipid-complex antibodies in immune-mediated neuropathies. Curr Opin Neurol. 2016;29(5):572-580. |
| 2016 | Grenade C, Moniotte N, Rompen E, Vanheusden A, Mainjot A, De Pauw-Gillet MC. A new method using insert-based systems (IBS) to improve cell behavior study on flexible and rigid biomaterials. Cytotechnology. 2016;68(6):2437-2448. |
| 2016 | LeBlond D, Altan S, Novick S, Peterson J, Shen Y, Yang H. In Vitro Dissolution Curve Comparisons: A Critique of Current Practice. Dissolution Technologies. 2016;23(01):14-23. |
| 2016 | Bayliss MK, Butler J, Feldman PL, et al. Quality guidelines for oral drug candidates: dose, solubility and lipophilicity. Drug Discov Today. 2016;21(10):1719-1727. |
| 2016 | Macdonald SJ, Fray MJ, McInally T. Passing on the medicinal chemistry baton: training undergraduates to be industry-ready through research projects between the University of Nottingham and GlaxoSmithKline. Drug Discov Today. 2016;21(6):880-887. |
| 2016 | Morgan SJ, Elangbam CS. Animal Models of Disease for Future Toxicity Predictions. Drug Discovery Toxicology: From Target Assessment to Translational Biomarkers: wiley; 2016:261-297. |
| 2016 | Hunter J. Adopting AI is essential for a sustainable pharma industry. Drug Discov World. 2016;17(1). |
| 2016 | Thevis M, Milosovich S, Licea-Perez H, Knecht D, Cavalier T, Schanzer W. Mass spectrometric characterization of a prolyl hydroxylase inhibitor GSK1278863, its bishydroxylated metabolite, and its implementation into routine doping controls. Drug Test Anal. 2016;8(8):858-863. |
| 2016 | Kemp IC, Hartwig T, Hamilton P, Wadley R, Bisten A. Production of fine lactose particles from organic solvent in laboratory and commercial-scale spray dryers. Drying Technology. 2015;34(7):830-842. |
| 2016 | Kemp IC, Hartwig T, Herdman R, Hamilton P, Bisten A, Bermingham S. Spray drying with a two-fluid nozzle to produce fine particles: Atomization, scale-up, and modeling. Drying Technology. 2015;34(10):1243-1252. |
| 2016 | Aich U, Lakbub J, Liu A. State-of-the-art technologies for rapid and high-throughput sample preparation and analysis of N-glycans from antibodies. Electrophoresis. 2016;37(11):1468-1488. |
| 2016 | Raschke M, Igl BW, Kenny J, et al. In Vivo Pig-a gene mutation assay: Guidance for 3Rs-friendly implementation. Environ Mol Mutagen. 2016;57(9):678-686. |
| 2016 | Pajk S, Zivec M, Sink R, et al. New direct inhibitors of InhA with antimycobacterial activity based on a tetrahydropyran scaffold. Eur J Med Chem. 2016;112:252-257. |
| 2016 | Ritchie TJ, Macdonald SJF. Heterocyclic replacements for benzene: Maximising ADME benefits by considering individual ring isomers. Eur J Med Chem. 2016;124:1057-1068. |
| 2016 | Shukla L, Ajram LA, Begg M, et al. 2,8-Diazaspiro[4.5]decan-8-yl)pyrimidin-4-amine potent CCR4 antagonists capable of inducing receptor endocytosis. Eur J Med Chem. 2016;115:14-25. |
| 2016 | Velthuisen EJ, Johns BA, Temelkoff DP, Brown KW, Danehower SC. The design of 8-hydroxyquinoline tetracyclic lactams as HIV-1 integrase strand transfer inhibitors. Eur J Med Chem. 2016;117:99-112. |
| 2016 | Holm R, Elder DP. Analytical advances in pharmaceutical impurity profiling. Eur J Pharm Sci. 2016;87:118-135. |
| 2016 | Knopp MM, Lobmann K, Elder DP, Rades T, Holm R. Recent advances and potential applications of modulated differential scanning calorimetry (mDSC) in drug development. Eur J Pharm Sci. 2016;87:164-173. |
| 2016 | Rossi M, Massai L, Diamanti D, et al. Multimodal molecular imaging system for pathway-specific reporter gene expression. Eur J Pharm Sci. 2016;86:136-142. |
| 2016 | Teague S, Valko K. How to identify and eliminate compounds with a risk of high clinical dose during the early phase of lead optimisation in drug discovery. Eur J Pharm Sci. 2017;110:37-50. |
| 2016 | Edeson SJ, Maduli EJM, Swanson S, Procopiou PA, Harrity JPA. Investigation of a Late-Stage Derivatization Approach to Isatogens: Discovery of New Reaction Pathways. European Journal of Organic Chemistry. 2016;2016(1):83-86. |
| 2016 | Elder DP, Newby P. Risk-based microbiological testing. Eur Pharm Rev. 2016;21(3):36-40. |
| 2016 | Contreras-Ruiz L, Mir FA, Turpie B, Krauss AH, Masli S. Sjogren's syndrome associated dry eye in a mouse model is ameliorated by topical application of integrin alpha4 antagonist GW559090. Exp Eye Res. 2016;143:1-8. |
| 2016 | Cao L, Qu Y, Zhang Z, Wang Z, Prytkova I, Wu S. Intact glycopeptide characterization using mass spectrometry. Expert Rev Proteomics. 2016;13(5):513-522. |
| 2016 | Sherry L, Lappin G, O'Donnell LE, et al. Viable Compositional Analysis of an Eleven Species Oral Polymicrobial Biofilm. Front Microbiol. 2016;7:912. |
| 2016 | Roberts A, Beaumont C, Manzarpour A, Mantle P. Purpurolic acid: A new natural alkaloid from Claviceps purpurea (Fr.) Tul. Fungal Biol. 2016;120(1):104-110. |
| 2016 | Zschuttig A, Auerbach C, Meltke S, et al. Complete Sequence of Probiotic Symbioflor 2 Escherichia coli Strain G3/10 and Draft Sequences of Symbioflor 2 E. coli Strains G1/2, G4/9, G5, G6/7, and G8. Genome Announc. 2015;3(2). |
| 2016 | Alder CM, Hayler JD, Henderson RK, et al. Updating and further expanding GSK's solvent sustainability guide. Green Chemistry. 2016;18(13):3879-3890. |
| 2016 | Gottlieb HE, Graczyk-Millbrandt G, Inglis GGA, et al. Development of GSK's NMR guides – a tool to encourage the use of more sustainable solvents. Green Chemistry. 2016;18(13):3867-3878. |
| 2016 | Sneddon HF. Safety first. Green Chemistry. 2016;18(19):5082-5085. |
| 2016 | Willis NJ, Fisher CA, Alder CM, et al. Sustainable synthesis of enantiopure fluorolactam derivatives by a selective direct fluorination – amidase strategy. Green Chemistry. 2016;18(5):1313-1318. |
| 2016 | Cardon LR, Harris T. Precision medicine, genomics and drug discovery. Hum Mol Genet. 2016;25(R2):R166-R172. |
| 2016 | Vasbinder MA, Locke P. Introduction: Global Laws, Regulations, and Standards for Animals in Research. ILAR J. 2016;57(3):261-265. |
| 2016 | Najjar M, Saleh D, Zelic M, et al. RIPK1 and RIPK3 Kinases Promote Cell-Death-Independent Inflammation by Toll-like Receptor 4. Immunity. 2016;45(1):46-59. |
| 2016 | Sokmen M, Akram Khan M. The antioxidant activity of some curcuminoids and chalcones. Inflammopharmacology. 2016;24(2-3):81-86. |
| 2016 | Gupta V, Khan A, Higham A, et al. The effect of phosphatidylinositol-3 kinase inhibition on matrix metalloproteinase-9 and reactive oxygen species release from chronic obstructive pulmonary disease neutrophils. Int Immunopharmacol. 2016;35:155-162. |
| 2016 | Pratten J, Wiecek J, Mordan N, et al. Physical disruption of oral biofilms by sodium bicarbonate: an in vitro study. Int J Dent Hyg. 2016;14(3):209-214. |
| 2016 | Goodwin DJ, Martini LG, Lawrence MJ. Production of nabumetone nanoparticles: Effect of molecular weight, concentration and nature of cellulose ether stabiliser. Int J Pharm. 2016;514(2):428-444. |
| 2016 | Song Y, Zemlyanov D, Chen X, et al. Acid-base interactions in amorphous solid dispersions of lumefantrine prepared by spray-drying and hot-melt extrusion using X-ray photoelectron spectroscopy. Int J Pharm. 2016;514(2):456-464. |
| 2016 | Barham JP, Coulthard G, Emery KJ, et al. KOtBu: A Privileged Reagent for Electron Transfer Reactions? J Am Chem Soc. 2016;138(23):7402-7410. |
| 2016 | Barham JP, John MP, Murphy JA. Contra-thermodynamic Hydrogen Atom Abstraction in the Selective C-H Functionalization of Trialkylamine N-CH3 Groups. J Am Chem Soc. 2016;138(47):15482-15487. |
| 2016 | Poulin MB, Schneck JL, Matico RE, et al. Nucleosome Binding Alters the Substrate Bonding Environment of Histone H3 Lysine 36 Methyltransferase NSD2. J Am Chem Soc. 2016;138(21):6699-6702. |
| 2016 | Yamatsugu K, Splain RA, Kiessling LL. Fidelity and Promiscuity of a Mycobacterial Glycosyltransferase. J Am Chem Soc. 2016;138(29):9205-9211. |
| 2016 | Ng T, Hor CH, Chew B, et al. Neuropilin 2 Signaling Is Involved in Cell Positioning of Adult-born Neurons through Glycogen Synthase Kinase-3beta (GSK3beta). J Biol Chem. 2016;291(48):25088-25095. |
| 2016 | Shcherbatko A, Rossi A, Foletti D, et al. Engineering Highly Potent and Selective Microproteins against Nav1.7 Sodium Channel for Treatment of Pain. J Biol Chem. 2016;291(27):13974-13986. |
| 2016 | Weston C, Winfield I, Harris M, et al. Receptor Activity-modifying Protein-directed G Protein Signaling Specificity for the Calcitonin Gene-related Peptide Family of Receptors. J Biol Chem. 2016;291(42):21925-21944. |
| 2016 | Gordon LJ, Allen M, Artursson P, et al. Direct Measurement of Intracellular Compound Concentration by RapidFire Mass Spectrometry Offers Insights into Cell Permeability. J Biomol Screen. 2016;21(2):156-164. |
| 2016 | Haslam C, Hellicar J, Dunn A, et al. The Evolution of MALDI-TOF Mass Spectrometry toward Ultra-High-Throughput Screening: 1536-Well Format and Beyond. J Biomol Screen. 2016;21(2):176-186. |
| 2016 | Leveridge M, Collier L, Edge C, et al. A High-Throughput Screen to Identify LRRK2 Kinase Inhibitors for the Treatment of Parkinson's Disease Using RapidFire Mass Spectrometry. J Biomol Screen. 2016;21(2):145-155. |
| 2016 | Zeng X, Montoute M, Bee TW, et al. A High-Content Imaging Screen for Cellular Regulators of beta-Catenin Protein Abundance. J Biomol Screen. 2016;21(3):260-268. |
| 2016 | Caltabiano AM, Foley JP, Barth HG. Size exclusion chromatography of synthetic polymers and biopolymers on common reversed phase and hydrophilic interaction chromatography columns. J Chromatogr A. 2016;1437:74-87. |
| 2016 | Close ED, Nwokeoji AO, Milton D, et al. Nucleic acid separations using superficially porous silica particles. J Chromatogr A. 2016;1440:135-144. |
| 2016 | Cui L, Jiang K, Liu DQ, Facchine KL. Simultaneous quantitation of trace level hydrazine and acetohydrazide in pharmaceuticals by benzaldehyde derivatization with sample 'matrix matching' followed by liquid chromatography-mass spectrometry. J Chromatogr A. 2016;1462:73-79. |
| 2016 | Licea Perez H, Knecht D, Evans CA. Overcoming bioanalytical challenges associated with the separation and quantitation of GSK1278863, a HIF-prolyl hydroxylase inhibitor, and its 14 stereoisomeric metabolites. J Chromatogr B Analyt Technol Biomed Life Sci. 2016;1009-1010:7-16. |
| 2016 | Bui HM, Enis D, Robciuc MR, et al. Proteolytic activation defines distinct lymphangiogenic mechanisms for VEGFC and VEGFD. J Clin Invest. 2016;126(6):2167-2180. |
| 2016 | Vallance P. Industry-Academic Relationship in a New Era of Drug Discovery. J Clin Oncol. 2016;34(29):3570-3575. |
| 2016 | Kunitomi T, Hashiguchi M, Mochizuki M. Application of Indirect Comparison to the Drug Development Process: Forecasting Direct Comparison Study Results. J Clin Pharmacol. 2016;56(9):1165-1170. |
| 2016 | Liu H, Sahi J. Role of Hepatic Drug Transporters in Drug Development. J Clin Pharmacol. 2016;56 Suppl 7:S11-22. |
| 2016 | Sherborne B, Shanmugasundaram V, Cheng AC, et al. Collaborating to improve the use of free-energy and other quantitative methods in drug discovery. J Comput Aided Mol Des. 2016;30(12):1139-1141. |
| 2016 | Ginex T, Munoz-Muriedas J, Herrero E, Gibert E, Cozzini P, Luque FJ. Development and validation of hydrophobic molecular fields derived from the quantum mechanical IEF/PCM-MST solvation models in 3D-QSAR. J Comput Chem. 2016;37(13):1147-1162. |
| 2016 | Moriwaki K, Farias Luz N, Balaji S, et al. The Mitochondrial Phosphatase PGAM5 Is Dispensable for Necroptosis but Promotes Inflammasome Activation in Macrophages. J Immunol. 2016;196(1):407-415. |
| 2016 | Peterson LW, Philip NH, Dillon CP, et al. Cell-Extrinsic TNF Collaborates with TRIF Signaling To Promote Yersinia-Induced Apoptosis. J Immunol. 2016;197(10):4110-4117. |
| 2016 | Hermanrud C, Ryner M, Luft T, et al. Development and validation of cell-based luciferase reporter gene assays for measuring neutralizing anti-drug antibodies against interferon beta. J Immunol Methods. 2016;430:1-9. |
| 2016 | Salzer E, Nixon E, Drewes G, Reinhard F, Bergamini G, Rau C. Screening Pools of Compounds against Multiple Endogenously Expressed Targets in a Chemoproteomics Binding Assay. J Lab Autom. 2016;21(1):133-142. |
| 2016 | Kerr WJ, Mudd RJ, Owens PK, Reid M, Brown JA, Campos S. Hydrogen isotope exchange with highly active iridium(I) NHC/phosphine complexes: a comparative counterion study. J Labelled Comp Radiopharm. 2016;59(14):601-603. |
| 2016 | Thiruchelvam U, Maybin JA, Armstrong GM, Greaves E, Saunders PT, Critchley HO. Cortisol regulates the paracrine action of macrophages by inducing vasoactive gene expression in endometrial cells. J Leukoc Biol. 2016;99(6):1165-1171. |
| 2016 | Bavetsias V, Lanigan RM, Ruda GF, et al. 8-Substituted Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors. J Med Chem. 2016;59(4):1388-1409. |
| 2016 | Biggadike K, Ahmed M, Ball DI, et al. Discovery of 6-Amino-2-{[(1S)-1-methylbutyl]oxy}-9-[5-(1-piperidinyl)pentyl]-7,9-dihydro-8H-pu rin-8-one (GSK2245035), a Highly Potent and Selective Intranasal Toll-Like Receptor 7 Agonist for the Treatment of Asthma. J Med Chem. 2016;59(5):1711-1726. |
| 2016 | Borthwick JA, Ancellin N, Bertrand SM, et al. Structurally Diverse Mitochondrial Branched Chain Aminotransferase (BCATm) Leads with Varying Binding Modes Identified by Fragment Screening. J Med Chem. 2016;59(6):2452-2467. |
| 2016 | Chen P, Chaikuad A, Bamborough P, et al. Discovery and Characterization of GSK2801, a Selective Chemical Probe for the Bromodomains BAZ2A and BAZ2B. J Med Chem. 2016;59(4):1410-1424. |
| 2016 | Davies TG, Wixted WE, Coyle JE, et al. Monoacidic Inhibitors of the Kelch-like ECH-Associated Protein 1: Nuclear Factor Erythroid 2-Related Factor 2 (KEAP1:NRF2) Protein-Protein Interaction with High Cell Potency Identified by Fragment-Based Discovery. J Med Chem. 2016;59(8):3991-4006. |
| 2016 | Haile PA, Votta BJ, Marquis RW, et al. The Identification and Pharmacological Characterization of 6-(tert-Butylsulfonyl)-N-(5-fluoro-1H-indazol-3-yl)quinolin-4-amine (GSK583), a Highly Potent and Selective Inhibitor of RIP2 Kinase. J Med Chem. 2016;59(10):4867-4880. |
| 2016 | Harris PA, King BW, Bandyopadhyay D, et al. DNA-Encoded Library Screening Identifies Benzo[b][1,4]oxazepin-4-ones as Highly Potent and Monoselective Receptor Interacting Protein 1 Kinase Inhibitors. J Med Chem. 2016;59(5):2163-2178. |
| 2016 | Keseru GM, Erlanson DA, Ferenczy GG, Hann MM, Murray CW, Pickett SD. Design Principles for Fragment Libraries: Maximizing the Value of Learnings from Pharma Fragment-Based Drug Discovery (FBDD) Programs for Use in Academia. J Med Chem. 2016;59(18):8189-8206. |
| 2016 | Knight A, Hemmings JL, Winfield I, et al. Discovery of Novel Adenosine Receptor Agonists That Exhibit Subtype Selectivity. J Med Chem. 2016;59(3):947-964. |
| 2016 | Lawhorn BG, Philp J, Graves AP, Holt DA, Gatto GJ, Jr., Kallander LS. Substituent Effects on Drug-Receptor H-bond Interactions: Correlations Useful for the Design of Kinase Inhibitors. J Med Chem. 2016;59(23):10629-10641. |
| 2016 | Le Manach C, Nchinda AT, Paquet T, et al. Identification of a Potential Antimalarial Drug Candidate from a Series of 2-Aminopyrazines by Optimization of Aqueous Solubility and Potency across the Parasite Life Cycle. J Med Chem. 2016;59(21):9890-9905. |
| 2016 | Maynard AT, Roberts CD. Quantifying, Visualizing, and Monitoring Lead Optimization. J Med Chem. 2016;59(9):4189-4201. |
| 2016 | Norcross NR, Baragana B, Wilson C, et al. Trisubstituted Pyrimidines as Efficacious and Fast-Acting Antimalarials. J Med Chem. 2016;59(13):6101-6120. |
| 2016 | Pitta E, Rogacki MK, Balabon O, et al. Searching for New Leads for Tuberculosis: Design, Synthesis, and Biological Evaluation of Novel 2-Quinolin-4-yloxyacetamides. J Med Chem. 2016;59(14):6709-6728. |
| 2016 | Russell S, Rahmani R, Jones AJ, et al. Hit-to-Lead Optimization of a Novel Class of Potent, Broad-Spectrum Trypanosomacides. J Med Chem. 2016;59(21):9686-9720. |
| 2016 | Theodoulou NH, Bamborough P, Bannister AJ, et al. Discovery of I-BRD9, a Selective Cell Active Chemical Probe for Bromodomain Containing Protein 9 Inhibition. J Med Chem. 2016;59(4):1425-1439. |
| 2016 | Westaway SM, Preston AG, Barker MD, et al. Cell Penetrant Inhibitors of the KDM4 and KDM5 Families of Histone Lysine Demethylases. 1. 3-Amino-4-pyridine Carboxylate Derivatives. J Med Chem. 2016;59(4):1357-1369. |
| 2016 | Westaway SM, Preston AG, Barker MD, et al. Cell Penetrant Inhibitors of the KDM4 and KDM5 Families of Histone Lysine Demethylases. 2. Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives. J Med Chem. 2016;59(4):1370-1387. |
| 2016 | Woolford AJ, Day PJ, Beneton V, et al. Fragment-Based Approach to the Development of an Orally Bioavailable Lactam Inhibitor of Lipoprotein-Associated Phospholipase A2 (Lp-PLA2). J Med Chem. 2016;59(23):10738-10749. |
| 2016 | Woolford AJ, Pero JE, Aravapalli S, et al. Exploitation of a Novel Binding Pocket in Human Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) Discovered through X-ray Fragment Screening. J Med Chem. 2016;59(11):5356-5367. |
| 2016 | Ginex T, Munoz-Muriedas J, Herrero E, Gibert E, Cozzini P, Luque FJ. Application of the quantum mechanical IEF/PCM-MST hydrophobic descriptors to selectivity in ligand binding. J Mol Model. 2016;22(6):136. |
| 2016 | Maiden TM, Swanson S, Procopiou PA, Harrity JP. Oxazoline-Promoted Rh-Catalyzed C-H Amidation of Benzene Derivatives with Sulfonamides and Trifluoroacetamide. A Comparative Study. J Org Chem. 2016;81(22):10641-10650. |
| 2016 | Vantourout JC, Law RP, Isidro-Llobet A, Atkinson SJ, Watson AJ. Chan-Evans-Lam Amination of Boronic Acid Pinacol (BPin) Esters: Overcoming the Aryl Amine Problem. J Org Chem. 2016;81(9):3942-3950. |
| 2016 | Scheipl S, Barnard M, Cottone L, et al. EGFR inhibitors identified as a potential treatment for chordoma in a focused compound screen. J Pathol. 2016;239(3):320-334. |
| 2016 | Kourentas A, Vertzoni M, Khadra I, et al. Evaluation of the Impact of Excipients and an Albendazole Salt on Albendazole Concentrations in Upper Small Intestine Using an In Vitro Biorelevant Gastrointestinal Transfer (BioGIT) System. J Pharm Sci. 2016;105(9):2896-2903. |
| 2016 | Skrdla PJ, Floyd PD, Dell'orco PC. Practical Estimation of Amorphous Solubility Enhancement Using Thermoanalytical Data: Determination of the Amorphous/Crystalline Solubility Ratio for Pure Indomethacin and Felodipine. J Pharm Sci. 2016;105(9):2625-2630. |
| 2016 | Weiss WFt, Gabrielson JP, Al-Azzam W, et al. Technical Decision Making With Higher Order Structure Data: Perspectives on Higher Order Structure Characterization From the Biopharmaceutical Industry. J Pharm Sci. 2016;105(12):3465-3470. |
| 2016 | Payseur JD, Rigney JJ, Turner SL, Wu X, Murphy DJ, Rossman EI. Evaluation of a method utilizing PhysioFlow(R), a novel signal morphology-based form of impedance cardiography, to measure cardiac output in the conscious beagle. J Pharmacol Toxicol Methods. 2016;81:115-119. |
| 2016 | Vinken P, Reagan WJ, Rodriguez LA, et al. Cross-laboratory analytical validation of the cardiac biomarker NT-proANP in rat. J Pharmacol Toxicol Methods. 2016;77:58-65. |
| 2016 | Kosumi D, Horibe T, Sugisaki M, Cogdell RJ, Hashimoto H. Photoprotection Mechanism of Light-Harvesting Antenna Complex from Purple Bacteria. J Phys Chem B. 2016;120(5):951-956. |
| 2016 | Ly R, Bouvier G, Szapiro G, et al. Contribution of postsynaptic T-type calcium channels to parallel fibre-Purkinje cell synaptic responses. J Physiol. 2016;594(4):915-936. |
| 2016 | Nolte T, Brander-Weber P, Dangler C, et al. Nonproliferative and Proliferative Lesions of the Gastrointestinal Tract, Pancreas and Salivary Glands of the Rat and Mouse. J Toxicol Pathol. 2016;29(1 Suppl):1S-125S. |
| 2016 | Guryanov SG, Liljeroos L, Kasaragod P, Kajander T, Butcher SJ. Crystal Structure of the Measles Virus Nucleoprotein Core in Complex with an N-Terminal Region of Phosphoprotein. J Virol. 2015;90(6):2849-2857. |
| 2016 | Lozano FJ, Freire P, Guillén-Gozalbez G, et al. New perspectives for sustainable resource and energy use, management and transformation: approaches from green and sustainable chemistry and engineering. Journal of Cleaner Production. 2016;118:1-3. |
| 2016 | Djekic L, Krajišnik D, Mićic Z, Čalija B. Formulation and physicochemical characterization of hydrogels with 18β-glycyrrhetinic acid/phospholipid complex phytosomes. Journal of Drug Delivery Science and Technology. 2016;35:81-90. |
| 2016 | Gates L, Adler RR, Elangbam CS. Osmium tetroxide post-fixation and periodic acid-Schiff dual-staining technique to demonstrate intracellular lipid and glycogen in the mouse liver section – a novel method for co-visualization of intracellular contents in paraffin-embedded tissue. Journal of Histotechnology. 2016;39(1):2-7. |
| 2016 | Hu J, Xia B, Elioff MS. A new terthiophene derivative as a fluorescent sensor for protein detection. Journal of Luminescence. 2016;173:57-65. |
| 2016 | Bate ST, Chatfield MJ. Using the structure of the experimental design and the randomization to construct a mixed model. J Qual Technol. 2016;48(4):365-387. |
| 2016 | Bate ST, Chatfield MJ. Identifying the structure of the experimental design. J Qual Technol. 2016;48(4):343-364. |
| 2016 | Berridge BR, Mowat V, Nagai H, et al. Non-proliferative and proliferative lesions of the cardiovascular system of the rat and mouse. J Toxicol Pathol. 2016;29(3):1S-47S. |
| 2016 | Bronstad A, Newcomer CE, Decelle T, Everitt JI, Guillen J, Laber K. Current concepts of Harm-Benefit Analysis of Animal Experiments - Report from the AALAS-FELASA Working Group on Harm-Benefit Analysis - Part 1. Lab Anim. 2016;50(1 Suppl):1-20. |
| 2016 | Sengers BG, McGinty S, Nouri FZ, et al. Modeling bispecific monoclonal antibody interaction with two cell membrane targets indicates the importance of surface diffusion. MAbs. 2016;8(5):905-915. |
| 2016 | Bahamontes-Rosa N, Alejandre AR, Gomez V, et al. New molecular settings to support in vivo anti-malarial assays. Malar J. 2016;15:147. |
| 2016 | Bahamontes-Rosa N, Gomez-Lorenzo MG, Lelievre J, et al. A novel validated assay to support the discovery of new anti-malarial gametocytocidal agents. Malar J. 2016;15(1):385. |
| 2016 | Arico-Muendel CC. From haystack to needle: finding value with DNA encoded library technology at GSK. MedChemComm. 2016;7(10):1898-1909. |
| 2016 | Tinworth CP, Lithgow H, Churcher I. Small molecule-mediated protein knockdown as a new approach to drug discovery. MedChemComm. 2016;7(12):2206-2216. |
| 2016 | Dai H, Ellis JL, Sinclair DA, Hubbard BP. Synthesis and Assay of SIRT1-Activating Compounds. Methods Enzymol. 2016;574:213-244. |
| 2016 | Toogood HS, Tait S, Jervis A, et al. Natural Product Biosynthesis in Escherichia coli: Mentha Monoterpenoids. Methods Enzymol. 2016;575:247-270. |
| 2016 | Aon JC, Sun J, Leighton JM, Appelbaum ER. Hypoxia-elicited impairment of cell wall integrity, glycosylation precursor synthesis, and growth in scaled-up high-cell density fed-batch cultures of Saccharomyces cerevisiae. Microb Cell Fact. 2016;15(1):142. |
| 2016 | Deleye S, Waldron AM, Richardson JC, et al. The Effects of Physiological and Methodological Determinants on 18F-FDG Mouse Brain Imaging Exemplified in a Double Transgenic Alzheimer Model. Mol Imaging. 2016;15. |
| 2016 | Schilderink R, Bell M, Reginato E, et al. BET bromodomain inhibition reduces maturation and enhances tolerogenic properties of human and mouse dendritic cells. Mol Immunol. 2016;79:66-76. |
| 2016 | Carlile GW, Robert R, Matthes E, et al. Latonduine Analogs Restore F508del-Cystic Fibrosis Transmembrane Conductance Regulator Trafficking through the Modulation of Poly-ADP Ribose Polymerase 3 and Poly-ADP Ribose Polymerase 16 Activity. Mol Pharmacol. 2016;90(2):65-79. |
| 2016 | Kotali A, Nasiopoulou DA, Tsoleridis CA, Harris PA, Kontogiorgis CA, Hadjipavlou-Litina DJ. Antioxidant Activity of 3-[N-(Acylhydrazono)ethyl]-4-hydroxy-coumarins. Molecules. 2016;21(2):138. |
| 2016 | Opletalova V, Dolezel J, Kunes J, Buchta V, Vejsova M, Kucerova-Chlupacova M. Synthesis and Antifungal Screening of 2-{[1-(5-Alkyl/arylalkylpyrazin-2-yl)ethylidene]hydrazono}-1,3-thiazolidin-4-ones. Molecules. 2016;21(11). |
| 2016 | Thybaud V, Kasper P, Sobol Z, et al. Genotoxicity assessment of peptide/protein-related biotherapeutics: points to consider before testing. Mutagenesis. 2016;31(4):375-384. |
| 2016 | Elkins JM, Fedele V, Szklarz M, et al. Comprehensive characterization of the Published Kinase Inhibitor Set. Nat Biotechnol. 2016;34(1):95-103. |
| 2016 | Stanzione M, Baumann M, Papanikos F, et al. Meiotic DNA break formation requires the unsynapsed chromosome axis-binding protein IHO1 (CCDC36) in mice. Nat Cell Biol. 2016;18(11):1208-1220. |
| 2016 | Johansson C, Velupillai S, Tumber A, et al. Structural analysis of human KDM5B guides histone demethylase inhibitor development. Nat Chem Biol. 2016;12(7):539-545. |
| 2016 | Abrahams KA, Chung CW, Ghidelli-Disse S, et al. Identification of KasA as the cellular target of an anti-tubercular scaffold. Nat Commun. 2016;7:12581. |
| 2016 | Kenthirapalan S, Waters AP, Matuschewski K, Kooij TW. Functional profiles of orphan membrane transporters in the life cycle of the malaria parasite. Nat Commun. 2016;7:10519. |
| 2016 | Martin K, Pritchett J, Llewellyn J, et al. PAK proteins and YAP-1 signalling downstream of integrin beta-1 in myofibroblasts promote liver fibrosis. Nat Commun. 2016;7:12502. |
| 2016 | Mole DJ, Webster SP, Uings I, et al. Kynurenine-3-monooxygenase inhibition prevents multiple organ failure in rodent models of acute pancreatitis. Nat Med. 2016;22(2):202-209. |
| 2016 | Cox JA, Abrahams KA, Alemparte C, et al. THPP target assignment reveals EchA6 as an essential fatty acid shuttle in mycobacteria. Nat Microbiol. 2016;1:15006. |
| 2016 | Hamilton JA, Cook AD, Tak PP. Anti-colony-stimulating factor therapies for inflammatory and autoimmune diseases. Nat Rev Drug Discov. 2016;16(1):53-70. |
| 2016 | Renaud JP, Chung CW, Danielson UH, et al. Biophysics in drug discovery: impact, challenges and opportunities. Nat Rev Drug Discov. 2016;15(10):679-698. |
| 2016 | Santos R, Ursu O, Gaulton A, et al. A comprehensive map of molecular drug targets. Nat Rev Drug Discov. 2017;16(1):19-34. |
| 2016 | Tough DF, Tak PP, Tarakhovsky A, Prinjha RK. Epigenetic drug discovery: breaking through the immune barrier. Nat Rev Drug Discov. 2016;15(12):835-853. |
| 2016 | Erwig LP, Gow NA. Interactions of fungal pathogens with phagocytes. Nat Rev Microbiol. 2016;14(3):163-176. |
| 2016 | Jiang L, Shestov AA, Swain P, et al. Reductive carboxylation supports redox homeostasis during anchorage-independent growth. Nature. 2016;532(7598):255-258. |
| 2016 | Patel AX, Bullmore ET. A wavelet-based estimator of the degrees of freedom in denoised fMRI time series for probabilistic testing of functional connectivity and brain graphs. Neuroimage. 2016;142:14-26. |
| 2016 | Blackwell C, Sherk C, Fricko M, et al. Inhibition of FGF/FGFR autocrine signaling in mesothelioma with the FGF ligand trap, FP-1039/GSK3052230. Oncotarget. 2016;7(26):39861-39871. |
| 2016 | Anderson JC, Campbell IB, Campos S, et al. Reductive conjugate addition nitro-Mannich route for the stereoselective synthesis of 1,2,3,4-tetrahydroquinoxalines. Org Biomol Chem. 2016;14(35):8270-8277. |
| 2016 | Anderson NA, Campbell IB, Fallon BJ, et al. Synthesis and determination of absolute configuration of a non-peptidic alphavbeta6 integrin antagonist for the treatment of idiopathic pulmonary fibrosis. Org Biomol Chem. 2016;14(25):5992-6009. |
| 2016 | Murray AT, Challinor JD, Gulacsy CE, et al. Modelling flavoenzymatic charge transfer events: development of catalytic indole deuteration strategies. Org Biomol Chem. 2016;14(15):3787-3792. |
| 2016 | Pilgrim BS, Gatland AE, Esteves CH, et al. Palladium-catalyzed enolate arylation as a key C-C bond-forming reaction for the synthesis of isoquinolines. Org Biomol Chem. 2016;14(3):1065-1090. |
| 2016 | Scotson JL, Andrews BI, Laws AP, Page MI. Phosphorothioate anti-sense oligonucleotides: the kinetics and mechanism of the generation of the sulfurising agent from phenylacetyl disulfide (PADS). Org Biomol Chem. 2016;14(35):8301-8308. |
| 2016 | Scotson JL, Andrews BI, Laws AP, Page MI. Phosphorothioate anti-sense oligonucleotides: the kinetics and mechanism of the sulfurisation of phosphites by phenylacetyl disulfide (PADS). Org Biomol Chem. 2016;14(46):10840-10847. |
| 2016 | Alamillo-Ferrer C, Karabourniotis-Sotti M, Kennedy AR, Campbell M, Tomkinson NC. Alkene Dioxygenation with Malonoyl Peroxides: Synthesis of gamma-Lactones, Isobenzofuranones, and Tetrahydrofurans. Org Lett. 2016;18(13):3102-3105. |
| 2016 | Green RA, Pletcher D, Leach SG, Brown RC. N-Heterocyclic Carbene-Mediated Microfluidic Oxidative Electrosynthesis of Amides from Aldehydes. Org Lett. 2016;18(5):1198-1201. |
| 2016 | Hatit MZ, Sadler JC, McLean LA, et al. Chemoselective Sequential Click Ligations Directed by Enhanced Reactivity of an Aromatic Ynamine. Org Lett. 2016;18(7):1694-1697. |
| 2016 | Maiden TM, Swanson S, Procopiou PA, Harrity JP. Synthesis of Functionalized Pyridines via a Regioselective Oxazoline Promoted C-H Amidation Reaction. Org Lett. 2016;18(14):3434-3437. |
| 2016 | Bandichhor R, Bhattacharya A, Bryan MC, et al. Green Chemistry Articles of Interest to the Pharmaceutical Industry. Organic Process Research & Development. 2016;20(7):1118-1132. |
| 2016 | Colleville AP, Horan RAJ, Olazabal S, Tomkinson NCO. C–H Arylation of Heterocyclic N-Oxides Through in Situ Diazotisation Of Anilines without Added Promoters: A Green And Selective Coupling Process. Organic Process Research & Development. 2016;20(7):1283-1296. |
| 2016 | Elliott LD, Berry M, Harji B, Klauber D, Leonard J, Booker-Milburn KI. A Small-Footprint, High-Capacity Flow Reactor for UV Photochemical Synthesis on the Kilogram Scale. Organic Process Research & Development. 2016;20(10):1806-1811. |
| 2016 | Kim JF, Gaffney PRJ, Valtcheva IB, et al. Organic Solvent Nanofiltration (OSN): A New Technology Platform for Liquid-Phase Oligonucleotide Synthesis (LPOS). Organic Process Research & Development. 2016;20(8):1439-1452. |
| 2016 | Matsuoka RT, Boros EE, Brown AD, et al. Development of Large-Scale Routes to Potent GPR119 Receptor Agonists. Organic Process Research & Development. 2016;20(8):1469-1475. |
| 2016 | Teci M, Tilley M, McGuire MA, Organ MG. Handling Hazards Using Continuous Flow Chemistry: Synthesis of N1-Aryl-[1,2,3]-triazoles from Anilines via Telescoped Three-Step Diazotization, Azidodediazotization, and [3 + 2] Dipolar Cycloaddition Processes. Organic Process Research & Development. 2016;20(11):1967-1973. |
| 2016 | Wang J, Zhang X, Wan Z, Ren F. TCDA: Practical Synthesis and Application in the Trifluoromethylation of Arenes and Heteroarenes. Organic Process Research & Development. 2016;20(4):836-839. |
| 2016 | Allen DW. Phosphines and related C-P bonded compounds. In: Allen DW, Tebby JC, Loakes D, eds. Organophosphorus Chemistry. Vol 45: Royal Society of Chemistry; 2016:1-50. |
| 2016 | Semmler E, Novak W, Allinson W, et al. Plasma Decontamination: A Case Study on Kill Efficacy of Geobacillus stearothermophilus Spores on Different Carrier Materials. PDA J Pharm Sci Technol. 2016;70(3):256-271. |
| 2016 | Mullen J, Cockell SJ, Tipney H, Woollard PM, Wipat A. Mining integrated semantic networks for drug repositioning opportunities. PeerJ. 2016;4:e1558. |
| 2016 | Vaas LAI, Witt G, Windshügel B, et al. Electronic laboratory notebooks in a public–private partnership. PeerJ Computer Science. 2016;2. |
| 2016 | Mareczky Z, Fehér A, Fehér C, Barta Z, Réczey K. Effects of pH and Aeration Conditions on Xylitol Production by Candida and Hansenula Yeasts. Periodica Polytechnica Chemical Engineering. 2016;60(1):54-59. |
| 2016 | Edwards CD, Luscombe C, Eddershaw P, Hessel EM. Development of a Novel Quantitative Structure-Activity Relationship Model to Accurately Predict Pulmonary Absorption and Replace Routine Use of the Isolated Perfused Respiring Rat Lung Model. Pharm Res. 2016;33(11):2604-2616. |
| 2016 | Lendrem DW, Lendrem BC, Rowland-Jones R, et al. Teaching examples for the design of experiments: geographical sensitivity and the self-fulfilling prophecy. Pharm Stat. 2016;15(1):90-92. |
| 2016 | Semmler E, Allinson W, Novak W, et al. Gaseous Plasma as a New Barrier System Inactivation of Geobacillus stearothermophilus Endospores, Validation Routine and Self-Decontamination Capabilities - Part 1. Pharm Ind. 2016;78(8):1186-1194. |
| 2016 | Semmler E, Novak W, Allinson W, et al. Gaseous plasma as a new barrier system. Pharm Ind. 2016;78(9):1350-1356. |
| 2016 | Szalkowski M, Ashraf KU, Lokstein H, Mackowski S, Cogdell RJ, Kowalska D. Silver island film substrates for ultrasensitive fluorescence detection of (bio)molecules. Photosynth Res. 2016;127(1):103-108. |
| 2016 | Blundell RK, Delorme AE, Smith EF, Licence P. An ARXPS and ERXPS study of quaternary ammonium and phosphonium ionic liquids: utilising a high energy Ag Lalpha' X-ray source. Phys Chem Chem Phys. 2016;18(8):6122-6131. |
| 2016 | Gupta K, Turkki V, Sherrill-Mix S, et al. Structural Basis for Inhibitor-Induced Aggregation of HIV Integrase. PLoS Biol. 2016;14(12):e1002584. |
| 2016 | Bentley B, Branicky R, Barnes CL, et al. The Multilayer Connectome of Caenorhabditis elegans. PLoS Comput Biol. 2016;12(12):e1005283. |
| 2016 | Ypma RJ, Bullmore ET. Statistical Analysis of Tract-Tracing Experiments Demonstrates a Dense, Complex Cortical Network in the Mouse. PLoS Comput Biol. 2016;12(9):e1005104. |
| 2016 | Le Bihan A, de Kanter R, Angulo-Barturen I, et al. Characterization of Novel Antimalarial Compound ACT-451840: Preclinical Assessment of Activity and Dose-Efficacy Modeling. PLoS Med. 2016;13(10):e1002138. |
| 2016 | Vallance P, Freeman A, Stewart M. Data Sharing as Part of the Normal Scientific Process: A View from the Pharmaceutical Industry. PLoS Med. 2016;13(1):e1001936. |
| 2016 | De Rycker M, Thomas J, Riley J, Brough SJ, Miles TJ, Gray DW. Identification of Trypanocidal Activity for Known Clinical Compounds Using a New Trypanosoma cruzi Hit-Discovery Screening Cascade. PLoS Negl Trop Dis. 2016;10(4):e0004584. |
| 2016 | Long T, Neitz RJ, Beasley R, et al. Structure-Bioactivity Relationship for Benzimidazole Thiophene Inhibitors of Polo-Like Kinase 1 (PLK1), a Potential Drug Target in Schistosoma mansoni. PLoS Negl Trop Dis. 2016;10(1):e0004356. |
| 2016 | Crowther GJ, Hillesland HK, Keyloun KR, et al. Biochemical Screening of Five Protein Kinases from Plasmodium falciparum against 14,000 Cell-Active Compounds. PLoS One. 2016;11(3):e0149996. |
| 2016 | Hart PJ, O'Shaughnessy CM, Siggins MK, et al. Differential Killing of Salmonella enterica Serovar Typhi by Antibodies Targeting Vi and Lipopolysaccharide O:9 Antigen. PLoS One. 2016;11(1):e0145945. |
| 2016 | Mullen J, Cockell SJ, Woollard P, Wipat A. An Integrated Data Driven Approach to Drug Repositioning Using Gene-Disease Associations. PLoS One. 2016;11(5):e0155811. |
| 2016 | Newton CL, Wood MD, Strange PG. Examining the Effects of Sodium Ions on the Binding of Antagonists to Dopamine D2 and D3 Receptors. PLoS One. 2016;11(7):e0158808. |
| 2016 | Van Voorhis WC, Adams JH, Adelfio R, et al. Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond. PLoS Pathog. 2016;12(7):e1005763. |
| 2016 | Lim HL, Hapgood KP, Haig B. Understanding and preventing agglomeration in a filter drying process. Powder Technology. 2016;300:146-156. |
| 2016 | MacDonald R, Rowe D, Martin E, Gorringe L. The spiral jet mill cut size equation. Powder Technology. 2016;299:26-40. |
| 2016 | Clancy D. Continuous secondary process selection and the modeling of batch and continuous wet granulation. Predictive Modeling of Pharmaceutical Unit Operations: Elsevier Inc.; 2016:342-381. |
| 2016 | Poulin MB, Schneck JL, Matico RE, et al. Transition state for the NSD2-catalyzed methylation of histone H3 lysine 36. Proc Natl Acad Sci U S A. 2016;113(5):1197-1201. |
| 2016 | Walker HJ, Steels C, Bendell L, et al. Understanding metabolism of arginine in biological systems via MALDI imaging. Proteomics. 2016;16(11-12):1690-1694. |
| 2016 | Gonçalves AD, Alexander C, Roberts CJ, Spain SG, Uddin S, Allen S. The effect of protein concentration on the viscosity of a recombinant albumin solution formulation. RSC Advances. 2016;6(18):15143-15154. |
| 2016 | Boulton L. Hiyama coupling. In: Blakemore D, Doyle P, Fobian Y, Thurston D, eds. RSC Drug Discovery Series. Vol 2016-January: Royal Society of Chemistry; 2016:104-121. |
| 2016 | Boulton L. Sonogashira coupling. In: Blakemore D, Doyle P, Fobian Y, Thurston D, eds. RSC Drug Discovery Series. Vol 2016-January: Royal Society of Chemistry; 2016:122-142. |
| 2016 | Scheer N, Chu X, Salphati L, Zamek-Gliszczynski MJ. Knockout and humanised animal models to study membrane transporters in drug development. In: Thurston D, Nicholls G, Youdim K, eds. RSC Drug Discovery Series. Vol 2016-January: Royal Society of Chemistry; 2016:298-332. |
| 2016 | Hayler J. From discovery to manufacturing: Some sustainability challenges presented by the requirements of medicine development. In: Jones LC, Sneddon HF, Clark J, Summerton L, Clark JH, eds. RSC Green Chemistry. Vol 2016-January: Royal Society of Chemistry; 2016:82-100. |
| 2016 | Sneddon HF. Tools for facilitating more sustainable medicinal chemistry. In: Jones LC, Sneddon HF, Clark J, Summerton L, Clark JH, eds. RSC Green Chemistry. Vol 2016-January: Royal Society of Chemistry; 2016:12-27. |
| 2016 | Coltherd JC, Rodgers DT, Lawrie RE, et al. The parasitic worm-derived immunomodulator, ES-62 and its drug-like small molecule analogues exhibit therapeutic potential in a model of chronic asthma. Sci Rep. 2016;6:19224. |
| 2016 | Dossang AC, Motshwene PG, Yang Y, et al. The N-terminal loop of IRAK-4 death domain regulates ordered assembly of the Myddosome signalling scaffold. Sci Rep. 2016;6:37267. |
| 2016 | Fieulaine S, Alves de Sousa R, Maigre L, et al. A unique peptide deformylase platform to rationally design and challenge novel active compounds. Sci Rep. 2016;6:35429. |
| 2016 | Khamis RY, Woollard KJ, Hyde GD, et al. Near Infrared Fluorescence (NIRF) Molecular Imaging of Oxidized LDL with an Autoantibody in Experimental Atherosclerosis. Sci Rep. 2016;6:21785. |
| 2016 | Scott RA, Freitag DF, Li L, et al. A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease. Sci Transl Med. 2016;8(341):341ra376. |
| 2017 | Xue L, Clements-Egan A, Amaravadi L, et al. Recommendations for the Assessment and Management of Pre-existing Drug-Reactive Antibodies During Biotherapeutic Development. The AAPS journal. 2017;19(6):1576-1586. |
| 2016 | Cai G, Christie JA, Archer GE, Zhou T. Interim Futility Analysis for Longitudinal Data With Adaptive Timing and Error Rate Preservation. Statistics in Biopharmaceutical Research. 2016;8(3):276-281. |
| 2016 | Li J, Ma J, Meng G, et al. BET bromodomain inhibition promotes neurogenesis while inhibiting gliogenesis in neural progenitor cells. Stem Cell Res. 2016;17(2):212-221. |
| 2017 | Clancy D, Hodnett N, Orr R, Owen M, Peterson J. Kinetic Model Development for Accelerated Stability Studies. AAPS PharmSciTech. 2017;18(4):1158-1176. |
| 2016 | Walker T, Harris K, Maifoshie E, Chaudhary K. Human Stem Cell-Derived Cardiomyocyte In Vitro Models for Cardiotoxicity Screening. Stem Cells in Toxicology and Medicine: wiley; 2016:85-121. |
| 2016 | Adams PD, Aertgeerts K, Bauer C, et al. Outcome of the First wwPDB/CCDC/D3R Ligand Validation Workshop. Structure. 2016;24(4):502-508. |
| 2017 | Frese A, Sutton PW, Turkenburg JP, Grogan G. Snapshots of the Catalytic Cycle of the Industrial Enzyme α-Amino-ε-Caprolactam Racemase (ACLR) Observed Using X-ray Crystallography. ACS Catalysis. 2017;7(2):1045-1048. |
| 2016 | Van Aller GS, Graves AP, Elkins PA, et al. Structure-Based Design of a Novel SMYD3 Inhibitor that Bridges the SAM-and MEKK2-Binding Pockets. Structure. 2016;24(5):774-781. |
| 2017 | Kerr WJ, Lindsay DM, Owens PK, Reid M, Tuttle T, Campos S. Site-Selective Deuteration of N-Heterocycles via Iridium-Catalyzed Hydrogen Isotope Exchange. ACS Catalysis. 2017;7(10):7182-7186. |
| 2017 | Potter ME, O’Malley AJ, Chapman S, et al. Understanding the Role of Molecular Diffusion and Catalytic Selectivity in Liquid-Phase Beckmann Rearrangement. ACS Catalysis. 2017;7(4):2926-2934. |
| 2016 | Jiménez-González C. Embedding Sustainability in Product and Process Development-The Role of Process Systems Engineers. Sustainability in the Design, Synthesis and Analysis of Chemical Engineering Processes: Elsevier Inc.; 2016:353-378. |
| 2017 | Slabu I, Galman JL, Lloyd RC, Turner NJ. Discovery, Engineering, and Synthetic Application of Transaminase Biocatalysts. ACS Catalysis. 2017;7(12):8263-8284. |
| 2016 | Gouverneur V, Verhoog S, Pfeifer L, et al. Silver-Mediated 18F-Labeling of Aryl-CF3 and Aryl-CHF2 with 18F-Fluoride. Synlett. 2015;27(01):25-28. |
| 2017 | Dittus L, Werner T, Muelbaier M, Bantscheff M. Differential Kinobeads Profiling for Target Identification of Irreversible Kinase Inhibitors. ACS Chem Biol. 2017;12(10):2515-2521. |
| 2016 | Kotali A, Maniadaki A, Kotali E, et al. Synthesis of Bicyclic Boron Heterocycles Containing [1,3,4,2]Oxadiazaborole and [1,3,2]Oxazaborine. Synthesis. 2016;48(23):4117-4125. |
| 2017 | Sadler JC, Chung CH, Mosley JE, Burley GA, Humphreys LD. Structural and Functional Basis of C-Methylation of Coumarin Scaffolds by NovO. ACS Chem Biol. 2017;12(2):374-379. |
| 2016 | Fink MJ, Snajdrova R, Winninger A, Mihovilovic MD. Regio- and stereoselective synthesis of chiral nitrilolactones using Baeyer–Villiger monooxygenases. Tetrahedron. 2016;72(46):7241-7248. |
| 2016 | Posner GH, Hatcher MA, Maio WA. Copper and silicon mediated, HMPA-free, n+3 ring expansions for the construction of medium sized lactones and lactams: short synthesis of (+)- cis -lauthisan. Tetrahedron. 2016;72(40):6025-6030. |
| 2017 | Aldrich CC, Calderon F. ACS Infectious Diseases Special Issue Focused on Drug Discovery for Global Health. ACS Infect Dis. 2017;3(5):329. |
| 2016 | Kotali A, Nasiopoulou DA, Harris PA. A novel and facile synthesis of 3,4-diacyl-2 H -pyran-2-ones. New C C bond formation. Tetrahedron Letters. 2016;57(31):3488-3490. |
| 2017 | Esposito M, Szadocka S, Degiacomi G, et al. A Phenotypic Based Target Screening Approach Delivers New Antitubercular CTP Synthetase Inhibitors. ACS Infect Dis. 2017;3(6):428-437. |
| 2016 | Procopiou PA, Hatley RJD, Lynn SM, Copley RCB, He Y, Minick DJ. Determination of the absolute configuration of (+)- and (−)-N-CBZ-3-fluoropyrrolidine-3-methanol using vibrational circular dichroism and confirmation of stereochemistry by conversion to (R)-tert-butyl 3-fluoro-3-(((R)-1-phenylethyl)carbamoyl)pyrrolidine-1-carboxylate. Tetrahedron: Asymmetry. 2016;27(24):1222-1230. |
| 2016 | Chanut FJ, Williams AM. The Syrian Golden Hamster Estrous Cycle: Unique Characteristics, Visual Guide to Staging, and Comparison with the Rat. Toxicol Pathol. 2016;44(1):43-50. |
| 2017 | Park Y, Pacitto A, Bayliss T, et al. Essential but Not Vulnerable: Indazole Sulfonamides Targeting Inosine Monophosphate Dehydrogenase as Potential Leads against Mycobacterium tuberculosis. ACS Infect Dis. 2017;3(1):18-33. |
| 2016 | Cullen JM, Faiola B, Melich DH, et al. Acute Alpha-Naphthylisothiocyanate-induced Liver Toxicity in Germfree and Conventional Male Rats. Toxicol Pathol. 2016;44(7):987-997. |
| 2017 | Abla N, Bashyam S, Charman SA, et al. Long-Lasting and Fast-Acting in Vivo Efficacious Antiplasmodial Azepanylcarbazole Amino Alcohol. ACS Med Chem Lett. 2017;8(12):1304-1308. |
| 2016 | Ball AL, Kamalian L, Alfirevic A, Lyon JJ, Chadwick AE. Identification of the Additional Mitochondrial Liabilities of 2-Hydroxyflutamide When Compared With its Parent Compound, Flutamide in HepG2 Cells. Toxicol Sci. 2016;153(2):341-351. |
| 2017 | Henley ZA, Bax BD, Inglesby LM, et al. From PIM1 to PI3Kdelta via GSK3beta: Target Hopping through the Kinome. ACS Med Chem Lett. 2017;8(10):1093-1098. |
| 2016 | Phillips JA, Holder DJ, Ennulat D, et al. Rat Urinary Osteopontin and Neutrophil Gelatinase-Associated Lipocalin Improve Certainty of Detecting Drug-Induced Kidney Injury. Toxicol Sci. 2016;151(2):214-223. |
| 2017 | Measom ND, Down KD, Hirst DJ, et al. Investigation of a Bicyclo[1.1.1]pentane as a Phenyl Replacement within an LpPLA2 Inhibitor. ACS Med Chem Lett. 2017;8(1):43-48. |
| 2016 | McDuffie JE, Chen Y, Ma JY, et al. Cisplatin nephrotoxicity in male beagle dogs: next-generation protein kidney safety biomarker tissue expression and related changes in urine. Toxicology Research. 2016;5(4):1202-1215 |
| 2017 | Parcella K, Eastman K, Yeung KS, et al. Improving Metabolic Stability with Deuterium: The Discovery of BMT-052, a Pan-genotypic HCV NS5B Polymerase Inhibitor. ACS Med Chem Lett. 2017;8(7):771-774. |
| 2016 | Harrison PL, Abdel-Rahman MA, Strong PN, Tawfik MM, Miller K. Characterisation of three alpha-helical antimicrobial peptides from the venom of Scorpio maurus palmatus. Toxicon. 2016;117:30-36. |
| 2017 | Procopiou PA, Ford AJ, Gore PM, et al. Design of Phthalazinone Amide Histamine H1 Receptor Antagonists for Use in Rhinitis. ACS Med Chem Lett. 2017;8(5):577-581. |
| 2016 | Cowan KJ, Amaravadi L, Cameron MJ, et al. Recommendations for Selection and Characterization of Protein Biomarker Assay Calibrator Material. The AAPS journal. 2017;19(6):1550-1563. |
| 2017 | Wang T, Bemis G, Hanzelka B, et al. Mtb PKNA/PKNB Dual Inhibition Provides Selectivity Advantages for Inhibitor Design To Minimize Host Kinase Interactions. ACS Med Chem Lett. 2017;8(12):1224-1229. |
| 2017 | Wang T, Bemis G, Hanzelka B, et al. Mtb PKNA/PKNB Dual Inhibition Provides Selectivity Advantages for Inhibitor Design To Minimize Host Kinase Interactions. ACS Med Chem Lett. 2017;8(12):1224-1229. |
| 2017 | Ross JF, Bridges A, Fletcher JM, et al. Decorating Self-Assembled Peptide Cages with Proteins. ACS Nano. 2017;11(8):7901-7914. |
| 2017 | Bax B, Chung CW, Edge C. Getting the chemistry right: protonation, tautomers and the importance of H atoms in biological chemistry. Acta crystallographica Section D, Structural biology. 2017;73(Pt 2):131-140. |
| 2017 | Deane CM, Wall ID, Green DV, Marsden BD, Bradley AR. WONKA and OOMMPPAA: analysis of protein-ligand interaction data to direct structure-based drug design. Acta crystallographica Section D, Structural biology. 2017;73(Pt 3):279-285. |
| 2017 | Maritan M, Cozzi R, Lo Surdo P, Veggi D, Bottomley MJ, Malito E. Crystal structures of human Fabs targeting the Bexsero meningococcal vaccine antigen NHBA. Acta Crystallogr F Struct Biol Commun. 2017;73(Pt 6):305-314. |
| 2017 | Taylor A, Budd DC, Shih B, et al. Transforming Growth Factor Beta Gene Signatures are Spatially Enriched in Keloid Tissue Biopsies and Ex vivo-Cultured Keloid Fibroblasts. Acta Derm Venereol. 2017;97(1):10-16. |
| 2017 | Wang P, Joberty G, Buist A, et al. Tau interactome mapping based identification of Otub1 as Tau deubiquitinase involved in accumulation of pathological Tau forms in vitro and in vivo. Acta Neuropathol. 2017;133(5):731-749. |
| 2017 | Valko KL, Teague SP, Pidgeon C. In vitro membrane binding and protein binding (IAM MB/PB technology) to estimate in vivo distribution: applications in early drug discovery. ADMET and DMPK. 2017;5(1):14. |
| 2017 | Roiban G-D, Kern M, Liu Z, et al. Efficient Biocatalytic Reductive Aminations by Extending the Imine Reductase Toolbox. ChemCatChem. 2017;9(24):4475-4479. |
| 2017 | Sanderson JN, Dominey AP, Percy JM. Iron-Catalyzed Isopropylation of Electron-Deficient Aryl and Heteroaryl Chlorides. Advanced Synthesis & Catalysis. 2017;359(6):1007-1017. |
| 2017 | Chen B, Lee K, Plucinak T, et al. A novel activation domain is essential for CIA5-mediated gene regulation in response to CO 2 changes in Chlamydomonas reinhardtii. Algal Research. 2017;24:207-217. |
| 2017 | Foley DJ, Craven PGE, Collins PM, et al. Synthesis and Demonstration of the Biological Relevance of sp(3) -rich Scaffolds Distantly Related to Natural Product Frameworks. Chemistry (Weinheim an der Bergstrasse, Germany). 2017;23(60):15227-15232. |
| 2017 | Griggs SD, Thompson N, Tape DT, Fabre M, Clarke PA. A Two-Step Synthesis of 2-Spiropiperidines. Chemistry (Weinheim an der Bergstrasse, Germany). 2017;23(39):9262-9265. |
| 2017 | Grego S, Dougherty ER, Alexander FJ, et al. Systems biology for organotypic cell cultures. ALTEX. 2017;34(2):301-310. |
| 2017 | Procter RJ, Dunsford JJ, Rushworth PJ, Hulcoop DG, Layfield RA, Ingleson MJ. A Zinc Catalyzed C(sp(3) )-C(sp(2) ) Suzuki-Miyaura Cross-Coupling Reaction Mediated by Aryl-Zincates. Chemistry (Weinheim an der Bergstrasse, Germany). 2017;23(63):15889-15893. |
| 2017 | Hokanson JA, Langdale CL, Sridhar A, Grill WM. OAB without an overactive bladder in the acute prostaglandin E2 rat model. American journal of physiology Renal physiology. 2017;313(5):F1169-F1177. |
| 2017 | Thiede S, Wosniok PR, Herkommer D, et al. Total Synthesis of Leupyrrins A1 and B1 , Highly Potent Antifungal Agents from the Myxobacterium Sorangium cellulosum. Chemistry (Weinheim an der Bergstrasse, Germany). 2017;23(14):3300-3320. |
| 2017 | Langdale CL, Hokanson JA, Sridhar A, Grill WM. Stimulation of the pelvic nerve increases bladder capacity in the prostaglandin E2 rat model of overactive bladder. American journal of physiology Renal physiology. 2017;313(3):F657-F665. |
| 2017 | Thiede S, Wosniok PR, Herkommer D, et al. Total Synthesis of Leupyrrins A1 and B1,Highly Potent Antifungal Agents from the Myxobacterium Sorangium cellulosum. Chemistry - A European Journal. 2017;23(14):3224-3224. |
| 2017 | Obeidat M, Nie Y, Fishbane N, et al. Integrative Genomics of Emphysema-Associated Genes Reveals Potential Disease Biomarkers. Am J Respir Cell Mol Biol. 2017;57(4):411-418. |
| 2017 | Dequirez G, Bourotte M, Porras de Francisco E, Remuiñan Blanco MJ, Déprez B, Willand N. Microwave-Assisted Suzuki-Miyaura Cross Coupling using Nickel as Catalyst to Rapidly Access to 3-Arylazetidine. ChemistrySelect. 2017;2(28):8841-8846. |
| 2017 | Ilie A, Roiban G-D, Reetz MT. Di-tert-butylN,N-diethylphosphoramidite as an Air Stable Ligand for Suzuki-Miyaura and Buchwald-Hartwig Reactions. ChemistrySelect. 2017;2(4):1392-1397. |
| 2017 | Esmaeilishirazifard E, De Vizio D, Moschos SA, Keshavarz T. Genomic and molecular characterization of a novel quorum sensing molecule in Bacillus licheniformis. AMB Express. 2017;7(1):78. |
| 2017 | Fillman-Holliday D, Everitt J. Animal Care and Use in Toxicity Testing. Comprehensive Toxicology. 3rd edition ed2018:75-94. |
| 2017 | Elder DP, Crowley PJ. Antimicrobial preservatives part two: Choosing a preservative. American Pharmaceutical Review. 2017;20(6). |
| 2017 | Chen C, Wicha SG, de Knegt GJ, et al. Assessing Pharmacodynamic Interactions in Mice Using the Multistate Tuberculosis Pharmacometric and General Pharmacodynamic Interaction Models. CPT: pharmacometrics & systems pharmacology. 2017;6(11):787-797. |
| 2017 | Newman CF, Havelund R, Passarelli MK, et al. Intracellular Drug Uptake-A Comparison of Single Cell Measurements Using ToF-SIMS Imaging and Quantification from Cell Populations with LC/MS/MS. Anal Chem. 2017;89(22):11944-11953. |
| 2017 | Watson SA, Edwards AJ, Parkinson JA. Standardless, Automated Determination of Chlorine-35 by 35Cl Nuclear Magnetic Resonance. Analytical Letters. 2016;50(1):161-172. |
| 2017 | Graves AP, Wall ID, Edge CM, et al. A Perspective on Water Site Prediction Methods for Structure Based Drug Design. Curr Top Med Chem. 2017;17(23):2599-2616. |
| 2017 | Licea-Perez H, Evans CA. New insights into supercritical fluid chromatography for chiral separations. Analytical Methods. 2017;9(17):2603-2610. |
| 2017 | Pansegrau W, Bagnoli F. Pilus Assembly in Gram-Positive Bacteria. Current topics in microbiology and immunology. 2017;404:203-233. |
| 2017 | Bew SP, Liddle J, Hughes DL, Pesce P, Thurston SM. Chiral Bronsted Acid-Catalyzed Asymmetric Synthesis of N-Aryl-cis-aziridine Carboxylate Esters. Angewandte Chemie (International ed in English). 2017;56(19):5322-5326. |
| 2017 | Fyfe JW, Fazakerley NJ, Watson AJ. Chemoselective Suzuki-Miyaura Cross-Coupling via Kinetic Transmetallation. Angewandte Chemie (International ed in English). 2017;56(5):1249-1253. |
| 2017 | Giuntini S, Balducci E, Cerofolini L, et al. Characterization of the Conjugation Pattern in Large Polysaccharide-Protein Conjugates by NMR Spectroscopy. Angewandte Chemie (International ed in English). 2017;56(47):14997-15001. |
| 2017 | Martinez-Saez N, Sun S, Oldrini D, et al. Oxetane Grafts Installed Site-Selectively on Native Disulfides to Enhance Protein Stability and Activity In Vivo. Angewandte Chemie (International ed in English). 2017;56(47):14963-14967. |
| 2017 | Michailidou F, Chung CW, Brown MJB, et al. Pac13 is a Small, Monomeric Dehydratase that Mediates the Formation of the 3'-Deoxy Nucleoside of Pacidamycins. Angewandte Chemie (International ed in English). 2017;56(41):12492-12497. |
| 2017 | Roushanbakhti A, Liu Y, Winship PCM, et al. Cobalt versus Osmium: Control of Both trans and cis Selectivity in Construction of the EFG Rings of Pectenotoxin 4. Angewandte Chemie (International ed in English). 2017;56(47):14883-14887. |
| 2017 | Smith AJ, Young A, Rohrbach S, et al. Electron-Transfer and Hydride-Transfer Pathways in the Stoltz-Grubbs Reducing System (KOtBu/Et3 SiH). Angewandte Chemie (International ed in English). 2017;56(44):13747-13751. |
| 2017 | Angiolilli C, Kabala PA, Grabiec AM, et al. Histone deacetylase 3 regulates the inflammatory gene expression programme of rheumatoid arthritis fibroblast-like synoviocytes. Ann Rheum Dis. 2017;76(1):277-285. |
| 2017 | Goodnow RA, Davie CP. DNA-Encoded Library Technology: A Brief Guide to Its Evolution and Impact on Drug Discovery. Annual Reports in Medicinal Chemistry. 2017;50:1-15. |
| 2017 | Bulik CC, Okusanya OO, Lakota EA, et al. Pharmacokinetic-Pharmacodynamic Evaluation of Gepotidacin against Gram-Positive Organisms Using Data from Murine Infection Models. Antimicrob Agents Chemother. 2017;61(2). |
| 2017 | Farrell DJ, Sader HS, Rhomberg PR, Scangarella-Oman NE, Flamm RK. In Vitro Activity of Gepotidacin (GSK2140944) against Neisseria gonorrhoeae. Antimicrob Agents Chemother. 2017;61(3). |
| 2017 | Brazier JB, Newton MA, Barreiro EM, Adrio LA, Naya L, Hii KKM. Solvent-dependent nuclearity, geometry and catalytic activity of [(SPhos)Pd(Ph)Cl]2. Dalton Trans. 2017;46(22):7223-7231. |
| 2017 | Flamm RK, Farrell DJ, Rhomberg PR, Scangarella-Oman NE, Sader HS. Gepotidacin (GSK2140944) In Vitro Activity against Gram-Positive and Gram-Negative Bacteria. Antimicrob Agents Chemother. 2017;61(7). |
| 2017 | Khaladkar M, Koscielny G, Hasan S, et al. Uncovering novel repositioning opportunities using the Open Targets platform. Drug Discov Today. 2017;22(12):1800-1807. |
| 2017 | Hoover JL, Singley CM, Elefante P, DeMarsh P, Zalacain M, Rittenhouse S. Reducing Antibacterial Development Risk for GSK1322322 by Exploring Potential Human Dose Regimens in Nonclinical Efficacy Studies Using Immunocompetent Rats. Antimicrob Agents Chemother. 2017;61(11). |
| 2017 | Matsumoto S, Singley CM, Hoover J, et al. Efficacy of Cefiderocol against Carbapenem-Resistant Gram-Negative Bacilli in Immunocompetent-Rat Respiratory Tract Infection Models Recreating Human Plasma Pharmacokinetics. Antimicrob Agents Chemother. 2017;61(9). |
| 2017 | Muliaditan M, Davies GR, Simonsson USH, Gillespie SH, Della Pasqua O. The implications of model-informed drug discovery and development for tuberculosis. Drug Discov Today. 2017;22(3):481-486. |
| 2017 | VanScoy BD, Tenero D, Turner S, et al. Pharmacokinetics-Pharmacodynamics of Tazobactam in Combination with Cefepime in an In Vitro Infection Model. Antimicrob Agents Chemother. 2017;61(12). |
| 2017 | Rozman K, Sosic I, Fernandez R, et al. A new 'golden age' for the antitubercular target InhA. Drug Discov Today. 2017;22(3):492-502. |
| 2017 | Wensel D, Sun Y, Li Z, et al. Discovery and Characterization of a Novel CD4-Binding Adnectin with Potent Anti-HIV Activity. Antimicrob Agents Chemother. 2017;61(8). |
| 2017 | Wang C, Zhou M, Zhang X, Yao J, Zhang Y, Mou Z. A lectin receptor kinase as a potential sensor for extracellular nicotinamide adenine dinucleotide in Arabidopsis thaliana. Elife. 2017;6. |
| 2017 | David B, Radziejwoski A, Toussaint F, et al. Natural DNA transformation is functional in Lactococcus lactis ssp. cremoris KW2. Appl Environ Microbiol. 2017. |
| 2017 | Hatch SB, Yapp C, Montenegro RC, et al. Assessing histone demethylase inhibitors in cells: lessons learned. Epigenetics & chromatin. 2017;10:9. |
| 2017 | Sannino F, Giuliani M, Salvatore U, et al. A novel synthetic medium and expression system for subzero growth and recombinant protein production in Pseudoalteromonas haloplanktis TAC125. Appl Microbiol Biotechnol. 2017;101(2):725-734. |
| 2017 | Tough DF, Prinjha RK. Immune disease-associated variants in gene enhancers point to BET epigenetic mechanisms for therapeutic intervention. Epigenomics. 2017;9(4):573-584. |
| 2017 | Scutellà B, Plana-Fattori A, Passot S, et al. 3D mathematical modelling to understand atypical heat transfer observed in vial freeze-drying. Applied Thermal Engineering. 2017;126:226-236. |
| 2017 | Kostrun S, Munic Kos V, Matanovic Skugor M, et al. Around the macrolide - Impact of 3D structure of macrocycles on lipophilicity and cellular accumulation. Eur J Med Chem. 2017;133:351-364. |
| 2017 | Talluri E, Pancotto L, Ruggiero P, Scarselli M, Balducci E. CagL from Helicobacter pylori has ADP-ribosylation activity and exerts partial protective efficacy in mice. Arch Biochem Biophys. 2017;635:102-109. |
| 2017 | Pitta E, Balabon O, Rogacki MK, et al. Differential characterization using readily accessible NMR experiments of novel N- and O-alkylated quinolin-4-ol, 1,5-naphthyridin-4-ol and quinazolin-4-ol derivatives with antimycobacterial activity. Eur J Med Chem. 2017;125:890-901. |
| 2017 | Sison-Young RL, Lauschke VM, Johann E, et al. A multicenter assessment of single-cell models aligned to standard measures of cell health for prediction of acute hepatotoxicity. Arch Toxicol. 2017;91(3):1385-1400. |
| 2017 | Zhen W, Liu A, Lu J, Zhang W, Tattersall D, Wang J. An Alternative Cuprizone-Induced Demyelination and Remyelination Mouse Model. ASN Neuro. 2017;9(4):1759091417725174. |
| 2017 | Hoffman AF, Simpson KJ, Horvath P, et al. SBI(2) HCS/HCA 3D Imaging: Best Practices and Unmet Needs Colloquium. Assay Drug Dev Technol. 2017;15(1):1-7. |
| 2017 | Otsuka F, Zhao X, Trout HH, et al. Community-based statins and advanced carotid plaque: Role of CD163 positive macrophages in lipoprotein-associated phospholipase A2 activity in atherosclerotic plaque. Atherosclerosis. 2017;267:78-89. |
| 2017 | Abberley L. Outsourcing of bioanalysis at GSK: a hybrid approach with a robust support model. Bioanalysis. 2017;9(15):1139-1144. |
| 2017 | Dong K, Tang D. Bioanalytical outsourcing strategy in China. Bioanalysis. 2017;9(15):1157-1159. |
| 2017 | Gunn GR, Evans C, Yang E. Immunogenicity and biomarkers: bioanalytical challenges and considerations. Bioanalysis. 2017;9(22):1729-1732. |
| 2017 | Gupta S, Richards S, Amaravadi L, et al. 2017 White Paper on recent issues in bioanalysis: a global perspective on immunogenicity guidelines & biomarker assay performance (Part 3 - LBA: immunogenicity, biomarkers and PK assays). Bioanalysis. 2017;9(24):1967-1996. |
| 2017 | Hottenstein C, Szapacs M, Fuller K, Evans C. Platforms and techniques used for biomarker assays: where are we now? Bioanalysis. 2017;9(14):1029-1031. |
| 2017 | Perez HL, Knecht D, Busz M. Overcoming challenges associated with the bioanalysis of an ester prodrug and its active acid metabolite. Bioanalysis. 2017;9(20):1589-1601. |
| 2017 | Spooner N, Anderson M, Dillen L, et al. The changing world of bioanalysis: summary of panel discussions. Bioanalysis. 2017;9(15):1175-1179. |
| 2017 | Spooner N, Cape S, Summerfield S. Outsourcing strategies in bioanalysis. Bioanalysis. 2017;9(15):1125-1126. |
| 2017 | Tang D, Zhong D, Dong K. The fourth China Bioanalysis Forum Annual Meeting. Bioanalysis. 2017;9(2):159-162. |
| 2017 | Welink J, Yang E, Hughes N, et al. 2017 White Paper on recent issues in bioanalysis: aren't BMV guidance/guidelines 'Scientific'? (Part 1 - LCMS: small molecules, peptides and small molecule biomarkers). Bioanalysis. 2017;9(22):1807-1825. |
| 2017 | Weaver RE, Mobarec JC, Wigglesworth MJ, Reynolds CA, Donnelly D. High affinity binding of the peptide agonist TIP-39 to the parathyroid hormone 2 (PTH2) receptor requires the hydroxyl group of Tyr-318 on transmembrane helix 5. Biochem Pharmacol. 2017;127:71-81. |
| 2017 | Lu X, Fan L, Phelps CB, Davie CP, Donahue CP. Ruthenium Promoted On-DNA Ring-Closing Metathesis and Cross-Metathesis. Bioconjug Chem. 2017;28(6):1625-1629. |
| 2017 | Bradley G, Barrett SJ. CausalR: extracting mechanistic sense from genome scale data. Bioinformatics. 2017;33(22):3670-3672. |
| 2017 | Bullmore ET. Parsing Anatomical Dysconnectivity in Psychosis. Biol Psychiatry. 2017;82(10):700-701. |
| 2017 | Fornito A, Bullmore ET, Zalesky A. Opportunities and Challenges for Psychiatry in the Connectomic Era. Biol Psychiatry Cogn Neurosci Neuroimaging. 2017;2(1):9-19. |
| 2017 | Schutte K, Szczepanska A, Halder M, et al. Modern science for better quality control of medicinal products "Towards global harmonization of 3Rs in biologicals": The report of an EPAA workshop. Biologicals. 2017;48:55-65. |
| 2017 | Poirier D, Renaud F, Dewar V, et al. Hepatitis B surface antigen incorporated in dissolvable microneedle array patch is antigenic and thermostable. Biomaterials. 2017;145:256-265. |
| 2017 | Aden A, Anderson P, Burnett GR, Lynch RJ, Tomlins PH. Longitudinal correlation of 3D OCT to detect early stage erosion in bovine enamel. Biomed Opt Express. 2017;8(2):954-973. |
| 2017 | Miah AH, Champigny AC, Graves RH, Hodgson ST, Percy JM, Procopiou PA. Identification of pyrazolopyrimidine arylsulfonamides as CC-chemokine receptor 4 (CCR4) antagonists. Bioorganic & medicinal chemistry. 2017;25(20):5327-5340. |
| 2017 | Ding X, Dai X, Long K, et al. Discovery of 5-substituent-N-arylbenzamide derivatives as potent, selective and orally bioavailable LRRK2 inhibitors. Bioorganic & medicinal chemistry letters. 2017;27(17):4034-4038. |
| 2017 | Lawhorn BG, Tran T, Hong VS, et al. Discovery of renin inhibitors containing a simple aspartate binding moiety that imparts reduced P450 inhibition. Bioorganic & medicinal chemistry letters. 2017;27(21):4838-4843. |
| 2017 | Liddle J, Beaufils B, Binnie M, et al. The discovery of potent and selective kynurenine 3-monooxygenase inhibitors for the treatment of acute pancreatitis. Bioorganic & medicinal chemistry letters. 2017;27(9):2023-2028. |
| 2017 | Martinez Gonzalez S, Hernandez AI, Alvarez RM, et al. Identification of novel PI3K inhibitors through a scaffold hopping strategy. Bioorganic & medicinal chemistry letters. 2017;27(21):4794-4799. |
| 2017 | Martinez Gonzalez S, Rodriguez-Aristegui S, Hernandez AI, et al. Generation of tricyclic imidazo[1,2-a]pyrazines as novel PI3K inhibitors by application of a conformational restriction strategy. Bioorganic & medicinal chemistry letters. 2017;27(11):2536-2543. |
| 2017 | Parcella K, Nickel A, Beno BR, et al. Discovery and initial optimization of alkoxyanthranilic acid derivatives as inhibitors of HCV NS5B polymerase. Bioorganic & medicinal chemistry letters. 2017;27(2):295-298. |
| 2017 | Procopiou PA, Ford AJ, Gore PM, et al. Identification of selective 8-(piperidin-4-yloxy)quinoline sulfone and sulfonamide histamine H1 receptor antagonists for use in allergic rhinitis. Bioorganic & medicinal chemistry letters. 2017;27(21):4914-4919. |
| 2017 | Sparks SM, Spearing PK, Diaz CJ, et al. Identification of potent, nonabsorbable agonists of the calcium-sensing receptor for GI-specific administration. Bioorganic & medicinal chemistry letters. 2017;27(20):4673-4677. |
| 2017 | Tang J, Jones SA, Jeffrey JL, et al. Discovery of a novel and potent class of anti-HIV-1 maturation inhibitors with improved virology profile against gag polymorphisms. Bioorganic & medicinal chemistry letters. 2017;27(12):2689-2694. |
| 2017 | Zheng BZ, D'Andrea SV, Hanumegowda U, et al. Discovery of BMS-961955, an allosteric inhibitor of the hepatitis C virus NS5B polymerase. Bioorganic & medicinal chemistry letters. 2017;27(15):3294-3300. |
| 2017 | Crespi F. Central [CNS] and Peripheral [Gastric Tissue] Selective Monitoring of Somatostatin (SRIF) with Micro-Sensor and Voltammetry in Rats: Influence of Growth Factors (GH, EGF). Biosensors (Basel). 2017;7(4). |
| 2017 | Frazier KS. Species Differences in Renal Development and Associated Developmental Nephrotoxicity. Birth Defects Res. 2017;109(16):1243-1256. |
| 2017 | Delgado-SanMartin JA, Hare JI, Davies EJ, Yates JWT. Multiscalar cellular automaton simulates in-vivo tumour-stroma patterns calibrated from in-vitro assay data. BMC Med Inform Decis Mak. 2017;17(1):70. |
| 2017 | Subbaiah MAM, Meanwell NA, Kadow JF. Design strategies in the prodrugs of HIV-1 protease inhibitors to improve the pharmaceutical properties. Eur J Med Chem. 2017;139:865-883. |
| 2017 | Chiang K, Zielinska AE, Shaaban AM, et al. PRMT5 Is a Critical Regulator of Breast Cancer Stem Cell Function via Histone Methylation and FOXP1 Expression. Cell Rep. 2017;21(12):3498-3513. |
| 2017 | Poce G, Consalvi S, Cocozza M, et al. Pharmaceutical salt of BM635 with improved bioavailability. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2017;99:17-23. |
| 2017 | Ponomarova O, Gabrielli N, Sevin DC, et al. Yeast Creates a Niche for Symbiotic Lactic Acid Bacteria through Nitrogen Overflow. Cell Syst. 2017;5(4):345-357 e346. |
| 2017 | Teague S, Valko K. How to identify and eliminate compounds with a risk of high clinical dose during the early phase of lead optimisation in drug discovery. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2017;110:37-50. |
| 2017 | Peng J, Docherty JH, Dominey AP, Thomas SP. Cobalt-catalysed Markovnikov selective hydroboration of vinylarenes. Chemical communications (Cambridge, England). 2017;53(34):4726-4729. |
| 2017 | Molloy JJ, Clohessy TA, Irving C, Anderson NA, Lloyd-Jones GC, Watson AJB. Chemoselective oxidation of aryl organoboron systems enabled by boronic acid-selective phase transfer. Chem Sci. 2017;8(2):1551-1559. |
| 2017 | Ewart L, Fabre K, Chakilam A, et al. Navigating tissue chips from development to dissemination: A pharmaceutical industry perspective. Exp Biol Med (Maywood). 2017;242(16):1579-1585. |
| 2017 | Belyanskaya SL, Ding Y, Callahan JF, Lazaar AL, Israel DI. Discovering Drugs with DNA-Encoded Library Technology: From Concept to Clinic with an Inhibitor of Soluble Epoxide Hydrolase. Chembiochem. 2017;18(9):837-842. |
| 2017 | Fan L, Davie CP. Zirconium(IV)-Catalyzed Ring Opening of on-DNA Epoxides in Water. Chembiochem. 2017;18(9):843-847. |
| 2017 | Sadler JC, Humphreys LD, Snajdrova R, Burley GA. A Tandem Enzymatic sp(2) -C-Methylation Process: Coupling in Situ S-Adenosyl-l-Methionine Formation with Methyl Transfer. Chembiochem. 2017;18(11):992-995. |
| 2017 | Andrei SA, Sijbesma E, Hann M, et al. Stabilization of protein-protein interactions in drug discovery. Expert Opin Drug Discov. 2017;12(9):925-940. |
| 2017 | Thomas B, Lu X, Birmingham WR, et al. Application of Biocatalysis to on-DNA Carbohydrate Library Synthesis. Chembiochem. 2017;18(9):858-863. |
| 2017 | Lu Q, Livi GP, Modha S, Yusa K, Macarron R, Dow DJ. Applications of CRISPR genome editing technology in drug target identification and validation. Expert Opin Drug Discov. 2017;12(6):541-552. |
| 2017 | Finnigan W, Thomas A, Cromar H, et al. Characterization of Carboxylic Acid Reductases as Enzymes in the Toolbox for Synthetic Chemistry. ChemCatChem. 2017;9(6):1005-1017. |
| 2017 | Reisdorf WC, Chhugani N, Sanseau P, Agarwal P. Harnessing public domain data to discover and validate therapeutic targets. Expert Opin Drug Discov. 2017;12(7):687-693. |
| 2017 | Liu J, Pang BQW, Adams JP, Snajdrova R, Li Z. Coupled Immobilized Amine Dehydrogenase and Glucose Dehydrogenase for Asymmetric Synthesis of Amines by Reductive Amination with Cofactor Recycling. ChemCatChem. 2017;9(3):425-431. |
| 2017 | Rees BJ, Tate M, Lynch AM, et al. Development of an in vitro PIG-A gene mutation assay in human cells. Mutagenesis. 2017;32(2):283-297. |
| 2017 | Axten JM. Protein kinase R(PKR)-like endoplasmic reticulum kinase (PERK) inhibitors: a patent review (2010-2015). Expert Opin Ther Pat. 2017;27(1):37-48. |
| 2017 | Rumsey WL, Bolognese B, Davis AB, et al. Effects of airborne toxicants on pulmonary function and mitochondrial DNA damage in rodent lungs. Mutagenesis. 2017;32(3):343-353. |
| 2017 | Hao R, Qi Y, Hou DN, et al. BDNF val66met Polymorphism Impairs Hippocampal Long-Term Depression by Down-Regulation of 5-HT3 Receptors. Front Cell Neurosci. 2017;11:306. |
| 2017 | Docherty JH, Peng J, Dominey AP, Thomas SP. Activation and discovery of earth-abundant metal catalysts using sodium tert-butoxide. Nat Chem. 2017;9(6):595-600. |
| 2017 | Reshetova P, van Schaik BD, Klarenbeek PL, et al. Computational Model Reveals Limited Correlation between Germinal Center B-Cell Subclone Abundancy and Affinity: Implications for Repertoire Sequencing. Front Immunol. 2017;8:221. |
| 2017 | Kellner S, DeMott MS, Cheng CP, et al. Oxidation of phosphorothioate DNA modifications leads to lethal genomic instability. Nat Chem Biol. 2017;13(8):888-894. |
| 2017 | Henke NA, Heider SAE, Hannibal S, Wendisch VF, Peters-Wendisch P. Isoprenoid Pyrophosphate-Dependent Transcriptional Regulation of Carotenogenesis in Corynebacterium glutamicum. Front Microbiol. 2017;8:633. |
| 2017 | Baker DA, Stewart LB, Large JM, et al. A potent series targeting the malarial cGMP-dependent protein kinase clears infection and blocks transmission. Nat Commun. 2017;8(1):430. |
| 2017 | Hutchinson JP, Rowland P, Taylor MRD, et al. Structural and mechanistic basis of differentiated inhibitors of the acute pancreatitis target kynurenine-3-monooxygenase. Nat Commun. 2017;8:15827. |
| 2017 | Ur Rahman S, Stanton M, Casey PG, et al. Development of a Click Beetle Luciferase Reporter System for Enhanced Bioluminescence Imaging of Listeria monocytogenes: Analysis in Cell Culture and Murine Infection Models. Front Microbiol. 2017;8:1797. |
| 2017 | Le Guiner C, Servais L, Montus M, et al. Long-term microdystrophin gene therapy is effective in a canine model of Duchenne muscular dystrophy. Nat Commun. 2017;8:16105. |
| 2017 | Zhang P, Wright JA, Osman AA, Nair SP. An aroD Ochre Mutation Results in a Staphylococcus aureus Small Colony Variant That Can Undergo Phenotypic Switching via Two Alternative Mechanisms. Front Microbiol. 2017;8:1001. |
| 2017 | Machutta CA, Kollmann CS, Lind KE, et al. Prioritizing multiple therapeutic targets in parallel using automated DNA-encoded library screening. Nat Commun. 2017;8:16081. |
| 2017 | Grandi A, Tomasi M, Zanella I, et al. Synergistic Protective Activity of Tumor-Specific Epitopes Engineered in Bacterial Outer Membrane Vesicles. Front Oncol. 2017;7:253. |
| 2017 | Sharma SV, Tong X, Pubill-Ulldemolins C, et al. Living GenoChemetics by hyphenating synthetic biology and synthetic chemistry in vivo. Nat Commun. 2017;8(1):229. |
| 2017 | Steff AM, Monroe J, Friedrich K, et al. Pre-fusion RSV F strongly boosts pre-fusion specific neutralizing responses in cattle pre-exposed to bovine RSV. Nat Commun. 2017;8(1):1085. |
| 2017 | Clegg MA, Tomkinson NC, Prinjha RK, Humphreys PG. Small molecules and their role in effective preclinical target validation. Future Med Chem. 2017;9(14):1579-1582. |
| 2017 | Hobbs BD, de Jong K, Lamontagne M, et al. Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis. Nat Genet. 2017;49(3):426-432. |
| 2017 | Creasy CL. Untangling the role of mutant histone H3 in diffuse intrinsic pontine glioma. Nat Med. 2017;23(4):413-414. |
| 2017 | Sevin DC, Fuhrer T, Zamboni N, Sauer U. Nontargeted in vitro metabolomics for high-throughput identification of novel enzymes in Escherichia coli. Nat Methods. 2017;14(2):187-194. |
| 2017 | Keseru GM, Hann MM. What is the future for fragment-based drug discovery? Future Med Chem. 2017;9(13):1457-1460. |
| 2017 | Schroter M, Paulsen O, Bullmore ET. Micro-connectomics: probing the organization of neuronal networks at the cellular scale. Nature reviews Neuroscience. 2017;18(3):131-146. |
| 2017 | Gasperini G, Arato V, Pizza M, Arico B, Leuzzi R. Physiopathological roles of spontaneously released outer membrane vesicles of Bordetella pertussis. Future Microbiol. 2017;12:1247-1259. |
| 2017 | Orr C, Vieira-Sousa E, Boyle DL, et al. Synovial tissue research: a state-of-the-art review. Nat Rev Rheumatol. 2017;13(8):463-475. |
| 2017 | Bloemendaal FM, Levin AD, Wildenberg ME, et al. Anti-Tumor Necrosis Factor With a Glyco-Engineered Fc-Region Has Increased Efficacy in Mice With Colitis. Gastroenterology. 2017;153(5):1351-1362 e1354. |
| 2017 | Kwokal A. Crystallisation Control by Process Analytical Technology. NATO Science for Peace and Security Series A: Chemistry and Biology. 2017:261-273. |
| 2017 | Kwokal A. Preparation, Stabilisation and Advantages of Metastable Polymorphs. NATO Science for Peace and Security Series A: Chemistry and Biology. 2017:247-260. |
| 2017 | Koenig SG, Sneddon HF. Recent advances in flow chemistry in the pharmaceutical industry. Green Chem. 2017;19(6):1418-1419. |
| 2017 | Gaulton A, Hersey A, Nowotka M, et al. The ChEMBL database in 2017. Nucleic Acids Res. 2017;45(D1):D945-D954. |
| 2017 | Khorsand F, Murphy CD, Whitehead AJ, Engel PC. Biocatalytic stereoinversion of d-para-bromophenylalanine in a one-pot three-enzyme reaction. Green Chem. 2017;19(2):503-510. |
| 2017 | Koscielny G, An P, Carvalho-Silva D, et al. Open Targets: a platform for therapeutic target identification and validation. Nucleic Acids Res. 2017;45(D1):D985-D994. |
| 2017 | Vulpis E, Cecere F, Molfetta R, et al. Genotoxic stress modulates the release of exosomes from multiple myeloma cells capable of activating NK cell cytokine production: Role of HSP70/TLR2/NF-kB axis. Oncoimmunology. 2017;6(3):e1279372. |
| 2017 | Martin B, Sedelmeier J, Bouisseau A, et al. Toolbox study for application of hydrogen peroxide as a versatile, safe and industrially-relevant green oxidant in continuous flow mode. Green Chem. 2017;19(6):1439-1448. |
| 2017 | Hayes TOP, Slater B, Horan RAJ, Radigois M, Wilden JD. A novel sulfonamide non-classical carbenoid: a mechanistic study for the synthesis of enediynes. Organic & biomolecular chemistry. 2017;15(46):9895-9902. |
| 2017 | Athanasopoulos T, Munye MM, Yanez-Munoz RJ. Nonintegrating Gene Therapy Vectors. Hematol Oncol Clin North Am. 2017;31(5):753-770. |
| 2017 | Anderson JC, Campbell IB, Campos S, Rundell CD, Shannon J, Tizzard GJ. Base-Controlled Diastereoselective Synthesis of Either anti- or syn-beta-Aminonitriles. Org Lett. 2017;19(7):1918-1921. |
| 2017 | Kassiri H, Salam MT, Pazhouhandeh MR, et al. Rail-to-Rail-Input Dual-Radio 64-Channel Closed-Loop Neurostimulator. IEEE Journal of Solid-State Circuits. 2017:1-18. |
| 2017 | Buchanan HS, Pauff SM, Kosmidis TD, et al. Modular, Step-Efficient Palladium-Catalyzed Cross-Coupling Strategy To Access C6-Heteroaryl 2-Aminopurine Ribonucleosides. Org Lett. 2017;19(14):3759-3762. |
| 2017 | Xu J, Mitra S, Van Hoof C, Yazicioglu RF, Makinwa KAA. Active Electrodes for Wearable EEG Acquisition: Review and Electronics Design Methodology. IEEE Rev Biomed Eng. 2017;10:187-198. |
| 2017 | Griffiths RJ, Burley GA, Talbot EP. Transition-Metal-Free Amine Oxidation: A Chemoselective Strategy for the Late-Stage Formation of Lactams. Org Lett. 2017;19(4):870-873. |
| 2017 | Spencer JA, Jamieson C, Talbot EPA. One-Pot, Three-Step Synthesis of Cyclopropylboronic Acid Pinacol Esters from Synthetically Tractable Propargylic Silyl Ethers. Org Lett. 2017;19(14):3891-3894. |
| 2017 | Mora Lopez C, Putzeys J, Raducanu BC, et al. A Neural Probe With Up to 966 Electrodes and Up to 384 Configurable Channels in 0.13 $\mu$m SOI CMOS. IEEE Trans Biomed Circuits Syst. 2017;11(3):510-522. |
| 2017 | Keles H, Susanne F, Livingstone H, et al. Development of a Robust and Reusable Microreactor Employing Laser Based Mid-IR Chemical Imaging for the Automated Quantification of Reaction Kinetics. Organic Process Research & Development. 2017;21(11):1761-1768. |
| 2017 | Roiban G-D, Sutton PW, Splain R, et al. Development of an Enzymatic Process for the Production of (R)-2-Butyl-2-ethyloxirane. Organic Process Research & Development. 2017;21(9):1302-1310. |
| 2017 | Everitt JI, Berridge BR. The Role of the IACUC in the Design and Conduct of Animal Experiments that Contribute to Translational Success. ILAR J. 2017;58(1):129-134. |
| 2017 | Murphy PS, Patel N, McCarthy TJ. Has molecular imaging delivered to drug development? Philosophical transactions Series A, Mathematical, physical, and engineering sciences. 2017;375(2107). |
| 2017 | Artois J, Blasdell K, Duong V, et al. Effects of mammarenavirus infection (Wenzhou virus) on the morphology of Rattus exulans. Infect Genet Evol. 2017. |
| 2017 | Percie du Sert N, Bamsey I, Bate ST, et al. The Experimental Design Assistant. PLoS Biol. 2017;15(9):e2003779. |
| 2017 | Bacconi M, Haag AF, Chiarot E, et al. In Vivo Analysis of Staphylococcus aureus-Infected Mice Reveals Differential Temporal and Spatial Expression Patterns of fhuD2. Infect Immun. 2017;85(10). |
| 2017 | Barsheshet Y, Wildbaum G, Levy E, et al. CCR8(+)FOXp3(+) Treg cells as master drivers of immune regulation. Proc Natl Acad Sci U S A. 2017;114(23):6086-6091. |
| 2017 | "Mateus A, Gordon LJ, Wayne GJ, et al. Prediction of intracellular exposure bridges the gap between target- and cell-based drug discovery. Proc Natl Acad Sci U S A. 2017;114(30):E6231-E6239." |
| 2017 | Lomax A, Patel S, Wang N, Kakar K, Kakar A, Bosma ML. A randomized controlled trial evaluating the efficacy of a 67% sodium bicarbonate toothpaste on gingivitis. Int J Dent Hyg. 2017;15(4):e35-e41. |
| 2017 | Palermo G, Miao Y, Walker RC, Jinek M, McCammon JA. CRISPR-Cas9 conformational activation as elucidated from enhanced molecular simulations. Proc Natl Acad Sci U S A. 2017;114(28):7260-7265. |
| 2017 | Sargison ND, Redman E, Morrison AA, et al. A method for single pair mating in an obligate parasitic nematode. Int J Parasitol. 2018;48(2):159-165. |
| 2017 | Turriani E, Lazaro DF, Ryazanov S, et al. Treatment with diphenyl-pyrazole compound anle138b/c reveals that alpha-synuclein protects melanoma cells from autophagic cell death. Proc Natl Acad Sci U S A. 2017;114(25):E4971-E4977. |
| 2017 | Wei Y, Wahome N, VanSlyke G, et al. Evaluation of lumazine synthase from Bacillus anthracis as a presentation platform for polyvalent antigen display. Protein science : a publication of the Protein Society. 2017;26(10):2059-2072. |
| 2017 | Akhtar WM, Cheong CB, Frost JR, Christensen KE, Stevenson NG, Donohoe TJ. Hydrogen Borrowing Catalysis with Secondary Alcohols: A New Route for the Generation of beta-Branched Carbonyl Compounds. J Am Chem Soc. 2017;139(7):2577-2580. |
| 2017 | Sabatini MT, Boulton LT, Sheppard TD. Borate esters: Simple catalysts for the sustainable synthesis of complex amides. Science advances. 2017;3(9):e1701028. |
| 2017 | Vantourout JC, Miras HN, Isidro-Llobet A, Sproules S, Watson AJ. Spectroscopic Studies of the Chan-Lam Amination: A Mechanism-Inspired Solution to Boronic Ester Reactivity. J Am Chem Soc. 2017;139(13):4769-4779. |
| 2017 | Abrahams KA, Cox JAG, Futterer K, et al. Inhibiting mycobacterial tryptophan synthase by targeting the inter-subunit interface. Sci Rep. 2017;7(1):9430. |
| 2017 | Foulkes MJ, Henry KM, Rougeot J, et al. Expression and regulation of drug transporters in vertebrate neutrophils. Sci Rep. 2017;7(1):4967. |
| 2017 | Gessner C, Steinchen W, Bedard S, et al. Computational method allowing Hydrogen-Deuterium Exchange Mass Spectrometry at single amide Resolution. Sci Rep. 2017;7(1):3789. |
| 2017 | Li X, Tao Y, Murphy JW, et al. The repeat region of cortactin is intrinsically disordered in solution. Sci Rep. 2017;7(1):16696. |
| 2017 | You S, Liu Y, Arp Z, et al. Intracellular imaging of docosanol in living cells by coherent anti-Stokes Raman scattering microscopy. J Biomed Opt. 2017;22(7):70502. |
| 2017 | Harrow I, Jimenez-Ruiz E, Splendiani A, et al. Matching disease and phenotype ontologies in the ontology alignment evaluation initiative. J Biomed Semantics. 2017;8(1):55. |
| 2017 | Tyler DS, Vappiani J, Caneque T, et al. Click chemistry enables preclinical evaluation of targeted epigenetic therapies. Science. 2017;356(6345):1397-1401. |
| 2017 | Lenselink EB, Ten Dijke N, Bongers B, et al. Beyond the hype: deep neural networks outperform established methods using a ChEMBL bioactivity benchmark set. J Cheminform. 2017;9(1):45. |
| 2017 | Chandler J, Haslam C, Hardy N, Leveridge M, Marshall P. A Systematic Investigation of the Best Buffers for Use in Screening by MALDI-Mass Spectrometry. SLAS discovery. 2017;22(10):1262-1269. |
| 2017 | Senger S. Assessment of the significance of patent-derived information for the early identification of compound-target interaction hypotheses. J Cheminform. 2017;9(1):26. |
| 2017 | Eglen RM, Klein JL. Three-Dimensional Cell Culture: A Rapidly Emerging Approach to Cellular Science and Drug Discovery. SLAS discovery. 2017;22(5):453-455. |
| 2017 | Blue LE, Franklin EG, Godinho JM, et al. Recent advances in capillary ultrahigh pressure liquid chromatography. Journal of chromatography A. 2017;1523:17-39. |
| 2017 | Pertusi DA, O'Donnell G, Homsher MF, et al. Prospective Assessment of Virtual Screening Heuristics Derived Using a Novel Fusion Score. SLAS discovery. 2017;22(8):995-1006. |
| 2017 | Thornton D, Yang X, Hsu L. Automated countercurrent chromatography method development and process scale-up at GlaxoSmithKline. Journal of chromatography A. 2017;1487:129-138. |
| 2017 | Rowedder JE, Ludbrook SB, Slack RJ. Determining the True Selectivity Profile of alphav Integrin Ligands Using Radioligand Binding: Applying an Old Solution to a New Problem. SLAS discovery. 2017;22(8):962-973. |
| 2017 | Ward DP, Hewitson P, Cardenas-Fernandez M, et al. Centrifugal partition chromatography in a biorefinery context: Optimisation and scale-up of monosaccharide fractionation from hydrolysed sugar beet pulp. Journal of chromatography A. 2017;1497:56-63. |
| 2017 | Vantourout JC, Isidro-Llobet A, Watson AJB. Conventional and Bioinspired Syntheses of Monoterpene Indole Alkaloids. Studies in Nature Products Chemistry. 2018;55:1-29. |
| 2017 | Manas ES, Green DV. CADD medicine: design is the potion that can cure my disease. J Comput Aided Mol Des. 2017;31(3):249-253. |
| 2017 | Tomkinson N, Jones D, Tellam J, Bresciani S, Wojno-Picon J, Cooper A. Preparation of Symmetrical and Nonsymmetrical Fluorene Sulfonamide Scaffolds. Synlett. 2016;28(05):577-582. |
| 2017 | Talbot E, Law R, Ukuser S, Tape D. Regioselective Synthesis of 3-Aminoimidazo[1,2-a]pyrimidines with Triflic Anhydride. Synthesis. 2017;49(16):3775-3793. |
| 2017 | Pirojsirikul T, Gotz AW, Weare J, Walker RC, Kowalski K, Valiev M. Combined quantum-mechanical molecular mechanics calculations with NWChem and AMBER: Excited state properties of green fluorescent protein chromophore analogue in aqueous solution. J Comput Chem. 2017;38(18):1631-1639. |
| 2017 | Jucker BM, Alsaid H, Rambo M, et al. Multimodal imaging approach to examine biodistribution kinetics of Cabotegravir (GSK1265744) long acting parenteral formulation in rat. Journal of controlled release : official journal of the Controlled Release Society. 2017;268:102-112. |
| 2017 | Ding X, Bai J, Wang H, Zhao B, Li J, Ren F. A mild and regioselective Ullmann reaction of indazoles with aryliodides in water. Tetrahedron. 2017;73(2):172-178. |
| 2017 | Li G, Nunoya JI, Cheng L, et al. Regulatory T Cells Contribute to HIV-1 Reservoir Persistence in CD4+ T Cells Through Cyclic Adenosine Monophosphate-Dependent Mechanisms in Humanized Mice In Vivo. The Journal of infectious diseases. 2017;216(12):1579-1591. |
| 2017 | Pattison G, Sandford G, Wilson I, et al. Polysubstituted and ring-fused pyridazine systems from tetrafluoropyridazine. Tetrahedron. 2017;73(5):437-454. |
| 2017 | Hemming DS, Talbot EP, Steel PG. A mild copper catalyzed method for the selective deprotection of aryl allyl ethers. Tetrahedron Letters. 2017;58(1):17-20. |
| 2017 | Kotali A, Maniadaki A, Kotali E, et al. New tetrahedral boron heterobicycles: Cyclocondensation of phenylboronic acid with β-keto butanoic acid N-acyl hydrazones. Tetrahedron Letters. 2017;58(6):512-515. |
| 2017 | Procopiou PA, Coe DM, Procopiou G. A re-investigation of the Fries rearrangement of 3-chlorophenyl acetate and synthesis of 2-azido-1-(4-(benzyloxy)-2-chlorophenyl)ethanone from 4-bromo-3-chlorophenol. Tetrahedron Letters. 2017;58(51):4766-4768. |
| 2017 | Procopiou PA, Barrett TN, Copley RCB, Tame CJ. Determination of the absolute configuration of two α v β 6 integrin inhibitors for the treatment of idiopathic pulmonary fibrosis and investigations on the asymmetric 1,4-addition of arylboronic acids to crotonate esters bearing a C4-oxygen substituent. Tetrahedron: Asymmetry. 2017;28(10):1384-1393. |
| 2017 | Brand S, Ko EJ, Viayna E, et al. Discovery and Optimization of 5-Amino-1,2,3-triazole-4-carboxamide Series against Trypanosoma cruzi. J Med Chem. 2017;60(17):7284-7299. |
| 2018 | Kern M, Roiban G-D, Fosberry A, Snajdrova R. CHAPTER 9. GSK: Biocatalyst Discovery and Optimisation. RSC Catalysis Series. 2017:257-275. |
| 2017 | Humphreys PG, Bamborough P, Chung CW, et al. Discovery of a Potent, Cell Penetrant, and Selective p300/CBP-Associated Factor (PCAF)/General Control Nonderepressible 5 (GCN5) Bromodomain Chemical Probe. J Med Chem. 2017;60(2):695-709. |
| 2018 | Martin J, Cantizani J, Peña I. Chapter 5. The Pursuit of Novel Anti-leishmanial Agents by High-throughput Screening (HTS) of Chemical Libraries. RSC Drug Discovery Series. 2017:77-100. |
| 2017 | Keune WJ, Potjewyd F, Heidebrecht T, et al. Rational Design of Autotaxin Inhibitors by Structural Evolution of Endogenous Modulators. J Med Chem. 2017;60(5):2006-2017. |
| 2018 | Oldrini D, Fiebig T, Romano MR, et al. Combined Chemical Synthesis and Tailored Enzymatic Elongation Provide Fully Synthetic and Conjugation-Ready Neisseria meningitidis Serogroup X Vaccine Antigens. ACS Chem Biol. 2018;13(4):984-994 |
| 2017 | Li X, Hernandez V, Rock FL, et al. Discovery of a Potent and Specific M. tuberculosis Leucyl-tRNA Synthetase Inhibitor: (S)-3-(Aminomethyl)-4-chloro-7-(2-hydroxyethoxy)benzo[c][1,2]oxaborol-1(3H)-ol (GSK656). J Med Chem. 2017;60(19):8011-8026. |
| 2018 | Zhu Z, Shaginian A, Grady LC, et al. Design and Application of a DNA-Encoded Macrocyclic Peptide Library. ACS Chem Biol. 2018;13(1):53-59 |
| 2018 | Cheung M, Tangirala RS, Bethi SR, et al. Discovery of Tetralones as Potent and Selective Inhibitors of Acyl-CoA:Diacylglycerol Acyltransferase 1. ACS Med Chem Lett. 2018;9(2):103-108. |
| 2017 | McInally T, Macdonald SJF. Unusual Undergraduate Training in Medicinal Chemistry in Collaboration between Academia and Industry. J Med Chem. 2017;60(19):7958-7964. |
| 2018 | Castellanos MM, Howell SC, Gallagher DT, Curtis JE. Characterization of the NISTmAb Reference Material using small-angle scattering and molecular simulation : Part I: Dilute protein solutions. Anal Bioanal Chem. 2018;410(8):2141-2159. |
| 2017 | Miller LM, Keune WJ, Castagna D, et al. Structure-Activity Relationships of Small Molecule Autotaxin Inhibitors with a Discrete Binding Mode. J Med Chem. 2017;60(2):722-748. |
| 2018 | Castellanos MM, Mattison K, Krueger S, Curtis JE. Characterization of the NISTmAb Reference Material using small-angle scattering and molecular simulation : Part II: Concentrated protein solutions. Anal Bioanal Chem. 2018;410(8):2161-2171. |
| 2017 | Miller LM, Pritchard JM, Macdonald SJF, Jamieson C, Watson AJB. Emergence of Small-Molecule Non-RGD-Mimetic Inhibitors for RGD Integrins. J Med Chem. 2017;60(8):3241-3251. |
| 2018 | Musetti C, Bean MF, Quinque GT, et al. High-Throughput Assessment of Structural Continuity in Biologics. Anal Chem. 2018;90(4):2970-2975 |
| 2017 | "Sandoval E, Lafuente-Monasterio MJ, Almela MJ, et al. The Discovery of Novel Antimalarial Aminoxadiazoles as a Promising Nonendoperoxide Scaffold. J Med Chem. 2017;60(16):6880-6896." |
| 2018 | Martin M, Legat B, Leenders J, et al. PepsNMR for (1)H NMR metabolomic data pre-processing. Anal Chim Acta. 2018;1019:1-13. |
| 2017 | Schwehm C, Kellam B, Garces AE, et al. Design and Elaboration of a Tractable Tricyclic Scaffold To Synthesize Druglike Inhibitors of Dipeptidyl Peptidase-4 (DPP-4), Antagonists of the C-C Chemokine Receptor Type 5 (CCR5), and Highly Potent and Selective Phosphoinositol-3 Kinase delta (PI3Kdelta) Inhibitors. J Med Chem. 2017;60(4):1534-1554. |
| 2018 | Hatley RJD, Macdonald SJF, Slack RJ, Le J, Ludbrook SB, Lukey PT. An alphav-RGD Integrin Inhibitor Toolbox: Drug Discovery Insight, Challenges and Opportunities. Angewandte Chemie (International ed in English). 2018;57(13):3298-3321. |
| 2017 | Thomson DW, Wagner AJ, Bantscheff M, et al. Discovery of a Highly Selective Tankyrase Inhibitor Displaying Growth Inhibition Effects against a Diverse Range of Tumor Derived Cell Lines. J Med Chem. 2017;60(13):5455-5471. |
| 2018 | Hoffman AF, Nolan J, Gebhard DF, et al. Society of Biomolecular Imaging and Informatics High-Content Screening/High-Content Analysis Emerging Technologies in Biological Models, When and Why? Assay Drug Dev Technol. 2018;16(1):1-6. |
| 2017 | Wilson CR, Gessner RK, Moosa A, et al. Novel Antitubercular 6-Dialkylaminopyrimidine Carboxamides from Phenotypic Whole-Cell High Throughput Screening of a SoftFocus Library: Structure-Activity Relationship and Target Identification Studies. J Med Chem. 2017;60(24):10118-10134. |
| 2018 | Gooris GS, Kamran M, Kros A, Moore DJ, Bouwstra JA. Interactions of dipalmitoylphosphatidylcholine with ceramide-based mixtures. Biochimica et biophysica acta. 2018;1860(6):1272-1281. |
| 2017 | Zhang W, Sartori MA, Makhnevych T, et al. Generation and Validation of Intracellular Ubiquitin Variant Inhibitors for USP7 and USP10. J Mol Biol. 2017;429(22):3546-3560. |
| 2018 | Deaton DN, Haffner CD, Henke BR, et al. 2,4-Diamino-8-quinazoline carboxamides as novel, potent inhibitors of the NAD hydrolyzing enzyme CD38: Exploration of the 2-position structure-activity relationships. Bioorganic & medicinal chemistry. 2018;26(8):2107-2150 |
| 2017 | Lissandrello CA, Gillis WF, Shen J, et al. A micro-scale printable nanoclip for electrical stimulation and recording in small nerves. J Neural Eng. 2017;14(3):036006. |
| 2018 | Hoggatt J, Singh P, Tate TA, et al. Rapid Mobilization Reveals a Highly Engraftable Hematopoietic Stem Cell. Cell. 2018;172(1-2):191-204 e110 |
| 2018 | Savitski MM, Zinn N, Faelth-Savitski M, et al. Multiplexed Proteome Dynamics Profiling Reveals Mechanisms Controlling Protein Homeostasis. Cell. 2018;173(1):260-274 e225. |
| 2018 | Chen H, Kankel MW, Su SC, Han SWS, Ofengeim D. Exploring the genetics and non-cell autonomous mechanisms underlying ALS/FTLD. Cell Death Differ. 2018;25(4):646-660. |
| 2017 | Reynolds DW, Campbell JM, Johnson BS, et al. The Degradation Chemistry of Farglitazar and Elucidation of the Oxidative Degradation Mechanisms. J Pharm Sci. 2017;106(4):982-993. |
| 2018 | Griffiths RJ, Kong WC, Richards SA, Burley GA, Willis MC, Talbot EPA. Oxidative beta-C-H sulfonylation of cyclic amines. Chem Sci. 2018;9(8):2295-2300. |
| 2017 | Edwards LM. Metabolic systems biology: a brief primer. The Journal of physiology. 2017;595(9):2849-2855. |
| 2018 | Cortada-Garcia M, Weheliye WH, Dore V, Mazzei L, Angeli P. Computational fluid dynamic studies of mixers for highly viscous shear thinning fluids and PIV validation. Chemical Engineering Science. 2018;179:133-149. |
| 2017 | Bate ST, Clark RA, Stanford SC. Using InVivoStat to perform the statistical analysis of experiments. Journal of psychopharmacology (Oxford, England). 2017;31(6):644-652. |
| 2018 | Nijsen M, Wu F, Bansal L, et al. Preclinical QSP Modeling in the Pharmaceutical Industry: An IQ Consortium Survey Examining the Current Landscape. CPT: pharmacometrics & systems pharmacology. 2018;7(3):135-146. |
| 2017 | Ferrero E, Dunham I, Sanseau P. In silico prediction of novel therapeutic targets using gene-disease association data. J Transl Med. 2017;15(1):182. |
| 2018 | Campbell IB, Macdonald SJF, Procopiou PA. Medicinal chemistry in drug discovery in big pharma: past, present and future. Drug Discov Today. 2018;23(2):219-234. |
| 2017 | Pinon AC, Schlagnitweit J, Berruyer P, et al. Measuring Nano- to Microstructures from Relayed Dynamic Nuclear Polarization NMR. The Journal of Physical Chemistry C. 2017;121(29):15993-16005. |
| 2017 | Binks BP, Fletcher PDI, Johnson AJ, Marinopoulos I, Crowther JM, Thompson MA. Spectrophotometry of Thin Films of Light-Absorbing Particles. Langmuir. 2017;33(15):3720-3730. |
| 2018 | Jeffery ND, Bate ST, Safayi S, Howard MA, 3rd, Moon L, Jeffery U. When neuroscience met clinical pathology: partitioning experimental variation to aid data interpretation in neuroscience. The European journal of neuroscience. 2018;47(5):371-379. |
| 2018 | Donovan BT, Bandyopadhyay D, Duraiswami C, Nixon CJ, Townsend CY, Martens SF. Discovery and electrophysiological characterization of SKF-32802: A novel hERG agonist found through a large-scale structural similarity search. Eur J Pharmacol. 2018;818:306-327 |
| 2017 | Ronchini C, Brozzi A, Riva L, et al. PML-RARA-associated cooperating mutations belong to a transcriptional network that is deregulated in myeloid leukemias. Leukemia. 2017;31(9):1975-1986. |
| 2018 | Saudemont A, Jespers L, Clay T. Current Status of Gene Engineering Cell Therapeutics. Front Immunol. 2018;9:153. |
| 2018 | Rojas-Lopez M, Zorgani MA, Kelley LA, et al. Identification of the Autochaperone Domain in the Type Va Secretion System (T5aSS): Prevalent Feature of Autotransporters with a beta-Helical Passenger. Front Microbiol. 2017;8:2607. |
| 2017 | Scott MJ, Lee JA, Wake MS, et al. 'In-Format' screening of a novel bispecific antibody format reveals significant potency improvements relative to unformatted molecules. MAbs. 2017;9(1):85-93. |
| 2018 | Staples NA, Goding JA, Gilmour AD, et al. Conductive Hydrogel Electrodes for Delivery of Long-Term High Frequency Pulses. Front Neurosci. 2017;11:748. |
| 2017 | Sewell F, Chapman K, Couch J, et al. Challenges and opportunities for the future of monoclonal antibody development: Improving safety assessment and reducing animal use. MAbs. 2017;9(5):742-755. |
| 2018 | Dalton SE, Dittus L, Thomas DA, et al. Selectively Targeting the Kinome-Conserved Lysine of PI3Kdelta as a General Approach to Covalent Kinase Inhibition. J Am Chem Soc. 2018;140(3):932-939. |
| 2017 | Lu X, Roberts SE, Franklin GJ, Davie CP. On-DNA Pd and Cu promoted C–N cross-coupling reactions. MedChemComm. 2017;8(8):1614-1617. |
| 2018 | Molloy JJ, Seath CP, West MJ, et al. Interrogating Pd(II) Anion Metathesis Using a Bifunctional Chemical Probe: A Transmetalation Switch. J Am Chem Soc. 2018;140(1):126-130. |
| 2017 | Taniguchi H, Henke NA, Heider SAE, Wendisch VF. Overexpression of the primary sigma factor gene sigA improved carotenoid production by Corynebacterium glutamicum: Application to production of beta-carotene and the non-native linear C50 carotenoid bisanhydrobacterioruberin. Metab Eng Commun. 2017;4:1-11. |
| 2018 | Carroll RG, Zaslona Z, Galvan-Pena S, et al. An unexpected link between fatty acid synthase and cholesterol synthesis in proinflammatory macrophage activation. The Journal of biological chemistry. 2018;293(15):5509-5521. |
| 2017 | Davies MN, Pere H, Bosschem I, et al. In Silico Adjuvant Design and Validation. Methods Mol Biol. 2017;1494:107-125. |
| 2018 | Cribbs A, Hookway ES, Wells G, et al. Inhibition of histone H3K27 demethylases selectively modulates inflammatory phenotypes of natural killer cells. The Journal of biological chemistry. 2018;293(7):2422-2437. |
| 2018 | Caltabiano AM, Foley JP, Striegel AM. Aqueous size-exclusion chromatography of polyelectrolytes on reversed-phase and hydrophilic interaction chromatography columns. Journal of chromatography A. 2018;1532:161-174. |
| 2018 | Caltabiano AM, Foley JP, Striegel AM. Organic solvent modifier and temperature effects in non-aqueous size-exclusion chromatography on reversed-phase columns. Journal of chromatography A. 2018;1531:83-103. |
| 2017 | Eckes B, Wang F, Rittie L, Scherr G, Zigrino P. Cell-Populated Collagen Lattice Models. Methods Mol Biol. 2017;1627:223-233. |
| 2018 | Bueno JM, Calderon F, Chicharro J, et al. Synthesis and Structure-Activity Relationships of the Novel Antimalarials 5-Pyridinyl-4(1 H)-Pyridones. J Med Chem. 2018;61(8):3422-3435. |
| 2017 | Kalxdorf M, Eberl HC, Bantscheff M. Monitoring Dynamic Changes of the Cell Surface Glycoproteome by Quantitative Proteomics. Methods Mol Biol. 2017;1647:47-59. |
| 2018 | Jeannot F, Taillier T, Despeyroux P, et al. Imidazopyrazinones (IPYs): Non-Quinolone Bacterial Topoisomerase Inhibitors Showing Partial Cross-Resistance with Quinolones. J Med Chem. 2018;61(8):3565-3581 |
| 2017 | Rittie L. Method for Picrosirius Red-Polarization Detection of Collagen Fibers in Tissue Sections. Methods Mol Biol. 2017;1627:395-407. |
| 2018 | Johansson P, Kaspersson K, Gurrell IK, et al. Toward beta-Secretase-1 Inhibitors with Improved Isoform Selectivity. J Med Chem. 2018;61(8):3491-3502. |
| 2017 | Rittie L. Type I Collagen Purification from Rat Tail Tendons. Methods Mol Biol. 2017;1627:287-308. |
| 2018 | Lu H, Yang T, Xu Z, et al. Discovery of Novel 1-Cyclopentenyl-3-phenylureas as Selective, Brain Penetrant, and Orally Bioavailable CXCR2 Antagonists. J Med Chem. 2018;61(6):2518-2532. |
| 2017 | Rittie L, Hutcheon AEK, Zieske JD. Mouse Models of Corneal Scarring. Methods Mol Biol. 2017;1627:117-122. |
| 2018 | Meanwell NA, Krystal MR, Nowicka-Sans B, et al. Inhibitors of HIV-1 Attachment: The Discovery and Development of Temsavir and its Prodrug Fostemsavir. J Med Chem. 2018;61(1):62-80. |
| 2017 | Worthen CA, Rittie L, Fisher GJ. Mechanical Deformation of Cultured Cells with Hydrogels. Methods Mol Biol. 2017;1627:245-251. |
| 2018 | Philp J, Lawhorn BG, Graves AP, et al. 4,6-Diaminopyrimidines as Highly Preferred Troponin I-Interacting Kinase (TNNI3K) Inhibitors. J Med Chem. 2018;61(7):3076-3088. |
| 2017 | Fakhar Z, Govender T, Maguire GEM, et al. Differential flap dynamics in l,d-transpeptidase2 from mycobacterium tuberculosis revealed by molecular dynamics. Mol Biosyst. 2017;13(6):1223-1234. |
| 2018 | Gillis WF, Lissandrello CA, Shen J, et al. Carbon fiber on polyimide ultra-microelectrodes. J Neural Eng. 2018;15(1):016010. |
| 2017 | Kalxdorf M, Gade S, Eberl HC, Bantscheff M. Monitoring Cell-surface N-Glycoproteome Dynamics by Quantitative Proteomics Reveals Mechanistic Insights into Macrophage Differentiation. Molecular & cellular proteomics : MCP. 2017;16(5):770-785. |
| 2018 | Hartkamp R, Moore TC, Iacovella CR, et al. Composition Dependence of Water Permeation Across Multicomponent Gel-Phase Bilayers. J Phys Chem B. 2018;122(12):3113-3123. |
| 2017 | Leufken J, Niehues A, Sarin LP, et al. pyQms enables universal and accurate quantification of mass spectrometry data. Molecular & cellular proteomics : MCP. 2017;16(10):1736-1745. |
| 2018 | Ching T, Himmelstein DS, Beaulieu-Jones BK, et al. Opportunities and obstacles for deep learning in biology and medicine. J R Soc Interface. 2018;15(141). |
| 2017 | Sassine J, Xu M, Sidiq KR, Emmins R, Errington J, Daniel RA. Functional redundancy of division specific penicillin-binding proteins in Bacillus subtilis. Mol Microbiol. 2017;106(2):304-318. |
| 2018 | Lozano FJ, Lozano R, Freire P, et al. New perspectives for green and sustainable chemistry and engineering: Approaches from sustainable resource and energy use, management, and transformation. Journal of Cleaner Production. 2018;172:227-232. |
| 2017 | Fuhrer T, Zampieri M, Sevin DC, Sauer U, Zamboni N. Genomewide landscape of gene-metabolome associations in Escherichia coli. Mol Syst Biol. 2017;13(1):907. |
| 2018 | Brown KK, Hann MM, Lakdawala AS, Santos R, Thomas PJ, Todd K. Approaches to target tractability assessment – a practical perspective. MedChemComm. 2018;9(4):606-613. |
| 2018 | Annibaldi A, Wicky John S, Vanden Berghe T, et al. Ubiquitin-Mediated Regulation of RIPK1 Kinase Activity Independent of IKK and MK2. Mol Cell. 2018;69(4):566-580 e565. |
| 2018 | Blakemore DC, Castro L, Churcher I, et al. Organic synthesis provides opportunities to transform drug discovery. Nat Chem. 2018;10(4):383-394. |
| 2018 | Ferdous MM, Bao Y, Vinciotti V, Liu X, Wilson P. Predicting gene expression from genome wide protein binding profiles. Neurocomputing. 2018;275:1490-1499. |
| 2018 | Ding H, Douglass EF, Jr., Sonabend AM, et al. Quantitative assessment of protein activity in orphan tissues and single cells using the metaVIPER algorithm. Nat Commun. 2018;9(1):1471. |
| 2018 | Edney D, Hulcoop DG, Leahy JH, et al. Development of Flexible and Scalable Routes to Two Phosphatidinylinositol-3-kinase Delta Inhibitors via a Common Intermediate Approach. Organic Process Research & Development. 2018;22(3):368-376. |
| 2018 | Mathieson T, Franken H, Kosinski J, et al. Systematic analysis of protein turnover in primary cells. Nat Commun. 2018;9(1):689. |
| 2018 | Oprea TI, Bologa CG, Brunak S, et al. Unexplored therapeutic opportunities in the human genome. Nature reviews Drug discovery. 2018;17(5):317-332. |
| 2018 | Nunn C, DiPietro A, Hodnett N, Sun P, Wells KM. High-Throughput Automated Design of Experiment (DoE) and Kinetic Modeling to Aid in Process Development of an API. Organic Process Research & Development. 2017;22(1):54-61. |
| 2018 | O’Brien AG, Ricci EM, Journet M. Dehydration of an Insoluble Urea Byproduct Enables the Condensation of DCC and Malonic Acid in Flow. Organic Process Research & Development. 2018;22(3):399-402. |
| 2018 | Norcliffe JL, Mina JG, Alvarez E, et al. Identifying inhibitors of the Leishmania inositol phosphorylceramide synthase with antiprotozoal activity using a yeast-based assay and ultra-high throughput screening platform. Sci Rep. 2018;8(1):3938. |
| 2018 | Trofimov V, Kicka S, Mucaria S, et al. Antimycobacterial drug discovery using Mycobacteria-infected amoebae identifies anti-infectives and new molecular targets. Sci Rep. 2018;8(1):3939. |
Our Preclinical Publications
The pre-clinical publications on this site have a GSK author. Please note that there may be other publications that are not listed here.