Vaccination with GSK 1024850A in children primed with GSK 1024850A & boosted with Pneumovax 23™

Male or female between, and including, 46-50 months of age at the time of vaccination.

• Subjects for whom the investigator believes that their parents/guardians can and will comply with the requirements of the protocol.
• Subjects who previously participated in study NCT00333450 in centres with more than 2 subjects and received a booster dose of Pneumovax 23™.
• Written informed consent obtained from both parents/guardians of the subject.
• Healthy subjects as established by medical history and clinical examination before entering into the study.

Use of any investigational or non-registered product other than the study vaccine(s) within 30 days preceding the vaccination, or planned use during the study period.

• Chronic administration of immunosuppressants or other immune-modifying drugs within six months prior to the vaccination.
• Planned administration/ administration of a vaccine not foreseen by the study protocol during the period starting one month before study vaccination and during the entire study period.
• Administration of any pneumococcal vaccine since the end of study NCT00333450.
• Administration of immunoglobulins and/or any blood products less than 3 months prior to the vaccination or planned use during the study period.
• Any confirmed or suspected immunosuppressive or immunodeficient condition, based on medical history and physical
• History of any neurologic disorders or seizures
• Anaphylactic reaction following previous administration of the vaccine or history of reactions or allergic disease likely to be exacerbated by any component of the vaccine.
• History of hypotonic-hyporesponsive episode after any previous vaccination.
• Major congenital defects or serious chronic illness.
• History of invasive pneumococcal diseases.
• Acute disease at the time of vaccination
• Rectal temperature >= 38.0°C or oral/axillary/tympanic temperature >= 37.5°C. A temperature greater than or equal to these cut-offs warrants deferral of the vaccination pending recovery of the subject.